RNAi screening: new approaches, understandings, and organisms.

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proc Natl Acad Sci U S A (2014) 2.25

RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol (2014) 1.54

Viruses and antiviral immunity in Drosophila. Dev Comp Immunol (2013) 1.16

UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. Genetics (2013) 1.14

Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res (2014) 1.03

Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Cell Rep (2013) 0.93

Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. PLoS One (2013) 0.93

Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens. Comb Chem High Throughput Screen (2013) 0.91

Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics (2014) 0.89

High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay. World J Virol (2013) 0.89

siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. Pharmaceuticals (Basel) (2013) 0.89

Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells. World J Gastroenterol (2013) 0.89

RNAi screening in Drosophila cells and in vivo. Methods (2014) 0.87

Thymosin β4 is not required for embryonic viability or vascular development. Circ Res (2013) 0.86

NEMix: single-cell nested effects models for probabilistic pathway stimulation. PLoS Comput Biol (2015) 0.86

Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods (2014) 0.84

Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC Genomics (2014) 0.83

A gene expression atlas of a bicoid-depleted Drosophila embryo reveals early canalization of cell fate. Development (2015) 0.81

An RNA interference screen for genes required to shape the anteroposterior compartment boundary in Drosophila identifies the Eph receptor. PLoS One (2014) 0.81

Tumor suppressor NF2/Merlin is a microtubule stabilizer. Cancer Res (2013) 0.81

Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target. Virol J (2015) 0.80

ScreenSifter: analysis and visualization of RNAi screening data. BMC Bioinformatics (2013) 0.80

Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. PLoS Negl Trop Dis (2015) 0.79

Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells. Braz J Med Biol Res (2014) 0.79

Functional genetics in the post-genomics era: building a better roadmap in Drosophila. Genetics (2013) 0.79

Nematode endogenous small RNA pathways. Worm (2014) 0.78

A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity. PLoS One (2013) 0.78

High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis. Assay Drug Dev Technol (2015) 0.77

Molecular biology approaches in bioadhesion research. Beilstein J Nanotechnol (2014) 0.76

Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms. Cytoskeleton (Hoboken) (2015) 0.76

Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen. BMC Bioinformatics (2015) 0.75

Functional genetics in the post-genomics era: building a better roadmap in Drosophila. G3 (Bethesda) (2013) 0.75

Design, simplified cloning, and in-silico analysis of multisite small interfering RNA-targeting cassettes. Mol Biol Res Commun (2016) 0.75

A computation using mutually exclusive processing is sufficient to identify specific Hedgehog signaling components. Front Genet (2013) 0.75

HTS-Net: An integrated regulome-interactome approach for establishing network regulation models in high-throughput screenings. PLoS One (2017) 0.75

Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Methods Mol Biol (2017) 0.75

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature (2007) 18.38

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics (2011) 12.98

Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods (2006) 6.96

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51

Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96

Exploring genetic interactions and networks with yeast. Nat Rev Genet (2007) 5.67

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15

Systems survey of endocytosis by multiparametric image analysis. Nature (2010) 5.03

High-throughput RNAi screening by time-lapse imaging of live human cells. Nat Methods (2006) 4.86

Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods (2009) 4.76

Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35

Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24

A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24

Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76

A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69

Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64

Discovery of insect and human dengue virus host factors. Nature (2009) 3.49

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29

High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22

The art and design of genetic screens: RNA interference. Nat Rev Genet (2008) 3.11

Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08

Mechanisms of dsRNA uptake in insects and potential of RNAi for pest control: a review. J Insect Physiol (2009) 3.01

CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging. Nat Methods (2010) 2.93

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91

Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Nat Methods (2004) 2.72

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64

RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc Natl Acad Sci U S A (2005) 2.59

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell (2009) 2.54

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (2009) 2.47

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nat Methods (2011) 2.47

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. RNA (2003) 2.41

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27

RNAi-mediated crop protection against insects. Trends Biotechnol (2008) 2.18

Antiviral immunity in Drosophila requires systemic RNA interference spread. Nature (2009) 2.15

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol (2010) 2.03

Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell (2011) 2.02

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01

In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet (2009) 1.99

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev (2010) 1.98

The many faces of RNAi. Dev Cell (2011) 1.94

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92

Automated microscopy for high-content RNAi screening. J Cell Biol (2010) 1.87

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86

Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85

RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82

A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol (2010) 1.77

Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev (2010) 1.71

Beyond Drosophila: RNAi in vivo and functional genomics in insects. Annu Rev Entomol (2010) 1.65

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Science (2009) 1.63

Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J Leukoc Biol (2011) 1.62

Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60

In vivo RNAi: today and tomorrow. Cold Spring Harb Perspect Biol (2010) 1.55

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2. Silence (2011) 1.53

Silencing of developmental genes in Hydra. Dev Biol (1999) 1.51

Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging. J Struct Biol (2009) 1.48

Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Mol Cell (2008) 1.48

Protein kinase signaling networks in cancer. Curr Opin Genet Dev (2010) 1.41

Combinatorial RNAi: a winning strategy for the race against evolving targets? Mol Ther (2007) 1.40

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters. Mol Biochem Parasitol (2010) 1.40

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. Mol Biochem Parasitol (2010) 1.39

A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Dev Cell (2010) 1.38

RNA interference for the study and genetic manipulation of ticks. Trends Parasitol (2007) 1.38

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. Blood (2011) 1.36

False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics (2011) 1.34

Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics (2008) 1.33

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development (2008) 1.30

Gene silencing by synthetic U1 adaptors. Nat Biotechnol (2009) 1.29

Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae. Proc Natl Acad Sci U S A (2009) 1.29

A parallel microfluidic flow cytometer for high-content screening. Nat Methods (2011) 1.28

RNAiCut: automated detection of significant genes from functional genomic screens. Nat Methods (2009) 1.28

RNA interference in schistosomes: machinery and methodology. Parasitology (2009) 1.27

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. Breast Cancer Res (2010) 1.25

Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proc Natl Acad Sci U S A (2011) 1.23

Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration. Biomicrofluidics (2011) 1.21

Design and evaluation of genome-wide libraries for RNA interference screens. Genome Biol (2010) 1.20

Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol (2010) 1.19

Second-generation sequencing supply an effective way to screen RNAi targets in large scale for potential application in pest insect control. PLoS One (2011) 1.15

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions? Curr Opin Microbiol (2008) 1.15

RNA interference of four genes in adult Bactrocera dorsalis by feeding their dsRNAs. PLoS One (2011) 1.15

Dissecting cancer pathways and vulnerabilities with RNAi. Cold Spring Harb Symp Quant Biol (2005) 1.15

A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell (2011) 1.14

RNAi and functional genomics in plant parasitic nematodes. Annu Rev Phytopathol (2009) 1.13

A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC Genomics (2011) 1.12

Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. Nat Protoc (2009) 1.11

Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem (2004) 1.10

Confirming specificity of RNAi in mammalian cells. Sci STKE (2002) 1.07

Identification of JAK/STAT pathway regulators--insights from RNAi screens. Semin Cell Dev Biol (2008) 1.06

Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics (2009) 1.06

What have RNAi screens taught us about viral-host interactions? Curr Opin Microbiol (2009) 1.04

In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PLoS One (2010) 1.04

Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases. Proc IEEE Int Symp Bioinformatics Bioeng (2007) 1.02

Crop improvement using small RNAs: applications and predictive ecological risk assessments. Trends Biotechnol (2009) 1.02

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85

An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88

Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75

The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11

Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96

Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50

Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73

A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24

Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell (2002) 4.08

Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92

Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85

Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76

Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (2005) 3.49

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39

Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29

Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (2005) 3.28

High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22

Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20

The emergence of geometric order in proliferating metazoan epithelia. Nature (2006) 3.13

Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08

Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell (2003) 3.05

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00

GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns (2006) 2.96

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66

Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63

Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol (2004) 2.62

Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56

The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47

Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47

A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45

FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43

The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev (2004) 2.37

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21

Genetic screening for signal transduction in the era of network biology. Cell (2007) 2.19

Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13

Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell (2012) 2.06

The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell (2004) 2.06

The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell (2002) 2.05

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05

Control of the mitotic cleavage plane by local epithelial topology. Cell (2011) 2.04

Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95

COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95

Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86

High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol (2005) 1.83

Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81

Drosophila and the genetics of the internal milieu. Nature (2007) 1.79

An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79

In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods (2007) 1.78

Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol (2011) 1.75

A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63

Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62

Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60

Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57

Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res (2011) 1.53

Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53

Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis (2002) 1.51

A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A (2007) 1.50

Hedgehog signal transduction: recent findings. Curr Opin Genet Dev (2002) 1.48

Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen (2008) 1.47

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene (2004) 1.43

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J (2002) 1.43

Tailoring the genome: the power of genetic approaches. Nat Genet (2003) 1.43

The Hippo signaling pathway interactome. Science (2013) 1.42

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev (2002) 1.42

Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development (2009) 1.41

SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell (2007) 1.40

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development (2002) 1.37

Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol (2003) 1.37

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Dev Biol (2004) 1.35

Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34

False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics (2011) 1.34

Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics (2008) 1.33

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell (2005) 1.31

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development (2008) 1.30

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell (2012) 1.29

RNAiCut: automated detection of significant genes from functional genomic screens. Nat Methods (2009) 1.28

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28

Cellular processes associated with germ band retraction in Drosophila. Dev Biol (2002) 1.27

Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol (2002) 1.25

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron (2002) 1.23

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. Biochim Biophys Acta (2002) 1.23