Published in Stroke on June 24, 2004
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ (2010) 7.93
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke (2010) 3.75
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology (2006) 3.22
Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol (2010) 3.05
Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke (2008) 2.84
Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol (2008) 2.71
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet (2007) 2.51
White matter hyperintensity volume is increased in small vessel stroke subtypes. Neurology (2010) 2.49
Effect of white-matter lesions on the risk of periprocedural stroke after carotid artery stenting versus endarterectomy in the International Carotid Stenting Study (ICSS): a prespecified analysis of data from a randomised trial. Lancet Neurol (2013) 2.26
Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol (2012) 2.17
Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke (2008) 2.12
Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology (2007) 2.05
Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative. Arch Neurol (2010) 1.94
Association of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology (2009) 1.94
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke (2005) 1.91
Self-reported sleep quality predicts poor cognitive performance in healthy older adults. J Gerontol B Psychol Sci Soc Sci (2009) 1.85
White matter hyperintensities and subclinical infarction: associations with psychomotor speed and cognitive flexibility. Stroke (2008) 1.84
Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging. Neurology (2012) 1.81
White matter hyperintensity penumbra. Stroke (2011) 1.78
Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Arch Gen Psychiatry (2010) 1.72
Association of alcohol consumption with brain volume in the Framingham study. Arch Neurol (2008) 1.71
Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) study. Stroke (2009) 1.70
White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke (2014) 1.68
Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care (2011) 1.66
Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke (2009) 1.66
Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation (2010) 1.57
Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke (2008) 1.52
Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. Am J Psychiatry (2008) 1.50
Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke (2007) 1.49
Automated measurement of brain and white matter lesion volume in type 2 diabetes mellitus. Diabetologia (2007) 1.45
Cerebral microbleeds: burden assessment by using quantitative susceptibility mapping. Radiology (2011) 1.41
Cerebrovascular disease, β-amyloid, and cognition in aging. Neurobiol Aging (2011) 1.37
Chronic cigarette smoking: implications for neurocognition and brain neurobiology. Int J Environ Res Public Health (2010) 1.36
Vascular burden and Alzheimer disease pathologic progression. Neurology (2012) 1.31
Brain behavior relationships among African Americans, whites, and Hispanics. Alzheimer Dis Assoc Disord (2008) 1.30
Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study. Ann Neurol (2013) 1.27
Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. Neuroimage (2011) 1.22
Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke. Stroke (2010) 1.17
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). Atherosclerosis (2011) 1.17
Neurocognitive function and CNS integrity in adult survivors of childhood hodgkin lymphoma. J Clin Oncol (2012) 1.16
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol (2008) 1.16
Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke (2015) 1.10
Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance study. Brain (2010) 1.09
Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke (2013) 1.07
Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr Neurosci (2013) 1.03
Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology (2015) 1.03
The myth of the normal, average human brain--the ICBM experience: (1) subject screening and eligibility. Neuroimage (2008) 1.02
Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke (2013) 1.02
Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes. J Stroke Cerebrovasc Dis (2010) 1.02
Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals. J Alzheimers Dis (2013) 1.01
Thrombogenic microvesicles and white matter hyperintensities in postmenopausal women. Neurology (2013) 1.01
Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study. Stroke (2011) 1.00
Magnetic resonance imaging traits in siblings discordant for Alzheimer disease. J Neuroimaging (2008) 0.99
Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology (2011) 0.99
Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability. Cerebrovasc Dis (2015) 0.97
Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls. Neurobiol Aging (2013) 0.95
The impact of vascular burden on late-life depression. Brain Res Rev (2009) 0.94
Subgroup of ADNI normal controls characterized by atrophy and cognitive decline associated with vascular damage. Psychol Aging (2013) 0.94
Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation (2012) 0.93
Age-related white matter changes. J Aging Res (2011) 0.93
Lack of association of white matter lesions with ipsilateral carotid artery stenosis. Cerebrovasc Dis (2012) 0.92
Increased white matter signal hyperintensities in long-term abstinent alcoholics compared with nonalcoholic controls. Alcohol Clin Exp Res (2008) 0.92
Extreme deep white matter hyperintensity volumes are associated with African American race. Cerebrovasc Dis (2014) 0.91
Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression. Psychiatry Res (2010) 0.91
Structural imaging measures of brain aging. Neuropsychol Rev (2014) 0.91
Intima-media thickness and age of first depressive episode. Biol Psychol (2008) 0.91
The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span. PLoS One (2013) 0.90
Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset. Am J Geriatr Psychiatry (2012) 0.90
Leukoaraiosis and collaterals in acute ischemic stroke. J Neuroimaging (2010) 0.89
Bivariate heritability of total and regional brain volumes: the Framingham Study. Alzheimer Dis Assoc Disord (2009) 0.88
Characterization of patients treated by rehabilitation service after establishing of an acute stroke unit in a Brazilian hospital. J Phys Ther Sci (2015) 0.87
Adverse vascular risk is related to cognitive decline in older adults. J Alzheimers Dis (2015) 0.87
Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities. Front Aging Neurosci (2014) 0.87
The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr (2011) 0.86
Association of matrix metalloproteinases with MRI indices of brain ischemia and aging. Neurobiol Aging (2009) 0.86
Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke (2009) 0.86
Biological basis of late life depression. Curr Psychiatry Rep (2012) 0.85
Does the Framingham Stroke Risk Profile predict white-matter changes in late-life depression? Int Psychogeriatr (2011) 0.84
Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study. Clin Neurol Neurosurg (2013) 0.84
The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults. Bipolar Disord (2010) 0.83
Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation (2015) 0.83
Candidate-gene analysis of white matter hyperintensities on neuroimaging. J Neurol Neurosurg Psychiatry (2015) 0.83
Tobacco smoking and MRI/MRS brain abnormalities compared to nonsmokers. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.83
Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment. Brain Struct Funct (2015) 0.83
Profiles by sex of brain MRI and cognitive function in the framingham offspring study. Alzheimer Dis Assoc Disord (2010) 0.82
Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Dis Assoc Disord (2014) 0.82
Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci (2015) 0.81
Age-dependent association between cigarette smoking on white matter hyperintensities. Neurol Sci (2011) 0.81
Hypertension, cognitive decline, and dementia: an epidemiological perspective. Dialogues Clin Neurosci (2007) 0.81
The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk. Am J Geriatr Pharmacother (2012) 0.81
Imaging small vessel-associated white matter changes in aging. Neuroscience (2013) 0.80
Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations. Age (Dordr) (2012) 0.80
Stroke: hyperlipidemia and cerebral small-vessel disease. Nat Rev Neurol (2010) 0.80
Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. Brain (2016) 0.80
Cerebral blood flow in small vessel disease: A systematic review and meta-analysis. J Cereb Blood Flow Metab (2016) 0.80
Association of vascular health and neurocognitive performance in overweight adults with high blood pressure. J Clin Exp Neuropsychol (2011) 0.79
Characterization of a normal control group: are they healthy? Neuroimage (2013) 0.79
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation (2008) 26.42
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med (2010) 14.49
Vitamin D deficiency and risk of cardiovascular disease. Circulation (2008) 13.39
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation (2007) 12.79
Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Stat Med (2004) 11.46
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 10.24
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90
Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med (2008) 9.68
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Stenting and medical therapy for atherosclerotic renal-artery stenosis. N Engl J Med (2013) 8.91
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 8.90
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation (2004) 8.80
Incidence of diabetes in youth in the United States. JAMA (2007) 8.70
Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med (2007) 8.59
Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation (2005) 8.54
Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation (2002) 8.49
Application of new cholesterol guidelines to a population-based sample. N Engl J Med (2014) 8.22
Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med (2012) 8.19
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet (2009) 7.27
The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics (2006) 7.19
Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med (2004) 7.12
Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med (2010) 7.03
Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. JAMA (2007) 6.95
National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke (2006) 6.94
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med (2002) 6.92
Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA (2002) 6.84
Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation (2003) 6.83
Obesity and the risk of new-onset atrial fibrillation. JAMA (2004) 6.73
Presentation of multivariate data for clinical use: The Framingham Study risk score functions. Stat Med (2004) 6.42
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation (2006) 5.97
Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med (2011) 5.94
Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. Neurobiol Aging (2005) 5.84
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
Incidence of Dementia over Three Decades in the Framingham Heart Study. N Engl J Med (2016) 5.55
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer Dis Assoc Disord (2009) 5.50
Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study. JAMA (2004) 5.34
Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab (2006) 5.33
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA (2006) 4.90
Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA (2004) 4.85
Association of smoking cessation and weight change with cardiovascular disease among adults with and without diabetes. JAMA (2013) 4.81
A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study. JAMA (2003) 4.77
Trends in cardiovascular complications of diabetes. JAMA (2004) 4.74
The lifetime risk of stroke: estimates from the Framingham Study. Stroke (2006) 4.68
Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA (2004) 4.63
Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med (2008) 4.63
Predicting the 30-year risk of cardiovascular disease: the framingham heart study. Circulation (2009) 4.62
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 4.62
A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study. Ann Intern Med (2008) 4.61
On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med (2011) 4.34
Estimating treatment effects using observational data. JAMA (2007) 4.12
Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation (2003) 4.09
Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study. Circulation (2005) 4.08
Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet (2002) 4.07
Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation (2007) 3.99
Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care (2002) 3.96
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Depressive symptoms and risk of stroke: the Framingham Study. Stroke (2006) 3.80
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80