Published in Proc Natl Acad Sci U S A on July 12, 2004
Bayesian analysis of genetic interactions in case-control studies, with application to adiponectin genes and colorectal cancer risk. Ann Hum Genet (2010) 1.23
A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits. PLoS One (2013) 1.20
Structures and Assumptions: Strategies to Harness Gene × Gene and Gene × Environment Interactions in GWAS. Stat Sci (2009) 1.18
A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet (2010) 1.14
Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. BMC Med Genet (2009) 1.03
High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions. PLoS One (2012) 1.00
Power of data mining methods to detect genetic associations and interactions. Hum Hered (2011) 0.89
A Bayesian multilocus association method: allowing for higher-order interaction in association studies. Genetics (2007) 0.87
A prostate cancer model build by a novel SVM-ID3 hybrid feature selection method using both genotyping and phenotype data from dbGaP. PLoS One (2014) 0.83
Clique-finding for heterogeneity and multidimensionality in biomarker epidemiology research: the CHAMBER algorithm. PLoS One (2009) 0.81
A conditional synergy index to assess biological interaction. Eur J Epidemiol (2009) 0.80
SNPs and other features as they predispose to complex disease: genome-wide predictive analysis of a quantitative phenotype for hypertension. PLoS One (2011) 0.79
Single nucleotide polymorphisms predict symptom severity of autism spectrum disorder. J Autism Dev Disord (2012) 0.77
Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk. J Hum Genet (2016) 0.76
Insulin resistance: regression and clustering. PLoS One (2014) 0.76
Network Based Prediction Model for Genomics Data Analysis. Stat Biosci (2012) 0.75
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biol (2000) 5.29
Use of classification trees for association studies. Genet Epidemiol (2000) 3.67
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (1992) 3.40
Molecular genetics of human blood pressure variation. Science (1996) 2.73
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension (1994) 2.41
Nephrogenic diabetes insipidus. Annu Rev Physiol (2001) 2.38
The insulin resistance syndrome. Curr Atheroscler Rep (2003) 1.26
Protein-tyrosine phosphatase activity in human adipocytes is strongly correlated with insulin-stimulated glucose uptake and is a target of insulin-induced oxidative inhibition. Metabolism (2003) 0.95
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. J Mol Med (Berl) (2001) 0.95
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. Hum Mol Genet (2001) 0.87
Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun (2002) 0.87
The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. Eur J Biochem (2002) 0.82
Clustering and the design of preference-assessment surveys in healthcare. Health Serv Res (1999) 0.82
Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci U S A (2002) 30.32
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Estimation of individual admixture: analytical and study design considerations. Genet Epidemiol (2005) 11.00
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71
Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet (2002) 4.76
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol (2005) 3.03
Midlife risk factors and healthy survival in men. JAMA (2006) 3.00
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
A method for calling gains and losses in array CGH data. Biostatistics (2005) 2.86
Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One (2010) 2.86
Systematic review: a century of inhalational anthrax cases from 1900 to 2005. Ann Intern Med (2006) 2.80
Recent genetic selection in the ancestral admixture of Puerto Ricans. Am J Hum Genet (2007) 2.72
Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies. Circulation (2007) 2.72
Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet (2008) 2.71
Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet (2002) 2.71
Pathway analysis of coronary atherosclerosis. Physiol Genomics (2005) 2.59
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Sample classification from protein mass spectrometry, by 'peak probability contrasts'. Bioinformatics (2004) 2.28
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet (2002) 2.27
Network analysis of human in-stent restenosis. Circulation (2006) 2.27
The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys (2009) 2.26
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res (2005) 2.24
Lower intake of magnesium and dietary fiber increases the incidence of type 2 diabetes in Taiwanese. J Formos Med Assoc (2012) 2.19
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Endothelial lipase is a major determinant of HDL level. J Clin Invest (2003) 2.12
Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol (2008) 2.12
Differences in vascular bed disease susceptibility reflect differences in gene expression response to atherogenic stimuli. Circ Res (2005) 2.10
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science (2008) 2.10
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes (2011) 2.09
Characterizing the admixed African ancestry of African Americans. Genome Biol (2009) 2.01
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest (2008) 1.89
Immunology: hepatitis A virus link to atopic disease. Nature (2003) 1.88
Th17 and Th1 T-cell responses in giant cell arteritis. Circulation (2010) 1.88
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet (2008) 1.81
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Canadian multidisciplinary core curriculum for musculoskeletal health. J Rheumatol (2006) 1.72
Statin and beta-blocker therapy and the initial presentation of coronary heart disease. Ann Intern Med (2006) 1.72
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res (2013) 1.68
Hepatic proprotein convertases modulate HDL metabolism. Cell Metab (2007) 1.68
Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J (2002) 1.67
Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation (2003) 1.66
MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol (2011) 1.64
Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance. Hum Reprod (2004) 1.58
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Is hyperuricemia another facet of the metabolic syndrome? J Chin Med Assoc (2006) 1.55
In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol (2007) 1.54
Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem (2004) 1.54
High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology. Nucleic Acids Res (2002) 1.51
Risk of cardiovascular disease from antiretroviral therapy for HIV: a systematic review. PLoS One (2013) 1.49
Ethnicity and nutrition of adolescent girls in Hawaii. J Am Diet Assoc (2006) 1.49
The plasma cell signature in autoimmune disease. Arthritis Rheumatol (2014) 1.47
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet (2002) 1.46
Parent-specific copy number in paired tumor-normal studies using circular binary segmentation. Bioinformatics (2011) 1.45
New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. BMC Cancer (2008) 1.45
The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Am J Hypertens (2008) 1.44
Ancestry-environment interactions and asthma risk among Puerto Ricans. Am J Respir Crit Care Med (2006) 1.42
ZoomQuant: an application for the quantitation of stable isotope labeled peptides. J Am Soc Mass Spectrom (2005) 1.41
Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development. Cardiovasc Res (2013) 1.40
Metabolic syndrome and early-onset coronary artery disease: is the whole greater than its parts? J Am Coll Cardiol (2006) 1.40
Identification of endothelial cell genes by combined database mining and microarray analysis. Physiol Genomics (2003) 1.39
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. Eur J Med Chem (2008) 1.36
Diabetes, insulin resistance, and dementia among HIV-1-infected patients. J Acquir Immune Defic Syndr (2005) 1.35
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem (2005) 1.34
Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol (2009) 1.34
Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics (2007) 1.32
Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Hypertension (2005) 1.32
Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence. Blood (2012) 1.31
Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol (2011) 1.30
Effect of green tea supplementation on insulin sensitivity in Sprague-Dawley rats. J Agric Food Chem (2004) 1.28
Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. Metabolism (2012) 1.28
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Am J Hum Genet (2013) 1.27
Insulin resistance independently predicts the progression of coronary artery calcification. Am Heart J (2009) 1.26
Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Magn Reson Med (2006) 1.25
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes (2013) 1.25
Dairy intake is associated with lower body fat and soda intake with greater weight in adolescent girls. J Nutr (2004) 1.25
Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. Physiol Genomics (2005) 1.22
Genotyping using the TaqMan assay. Curr Protoc Hum Genet (2008) 1.22
Frequency effects of Chinese character processing in the brain: an event-related fMRI study. Neuroimage (2003) 1.21
Dissecting complex diseases in complex populations: asthma in latino americans. Proc Am Thorac Soc (2007) 1.21
Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr (2004) 1.21
Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses. J Mol Cell Cardiol (2004) 1.21
Estrogen receptor-negative invasive breast cancer: imaging features of tumors with and without human epidermal growth factor receptor type 2 overexpression. Radiology (2008) 1.21
Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 1.19
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol (2009) 1.19
Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. J Biol Chem (2004) 1.18