Published in Cancer Cell on July 07, 2009
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell (2012) 2.75
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest (2010) 2.42
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov (2012) 2.39
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol (2009) 2.25
Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A (2011) 2.24
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med (2012) 2.02
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet (2013) 1.69
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta (2010) 1.59
Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54
The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol (2012) 1.53
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science (2014) 1.53
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Emerging interactions between skin stem cells and their niches. Nat Med (2014) 1.45
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res (2010) 1.45
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol (2014) 1.40
Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell (2016) 1.40
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res (2011) 1.33
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology (2010) 1.29
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development (2011) 1.25
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol (2014) 1.20
Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer (2010) 1.15
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Multifocal epithelial tumors and field cancerization: stroma as a primary determinant. J Clin Invest (2014) 1.10
Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis. PLoS One (2011) 1.09
Notch: a key regulator of tumor angiogenesis and metastasis. Histol Histopathol (2012) 1.05
The role of RAD9 in tumorigenesis. J Mol Cell Biol (2011) 1.04
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet (2012) 1.02
Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene (2014) 0.99
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One (2012) 0.98
Rabconnectin-3 is a functional regulator of mammalian Notch signaling. J Biol Chem (2010) 0.98
Notch signaling in prostate cancer: a moving target. Prostate (2014) 0.98
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo. PLoS One (2010) 0.97
Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med (2013) 0.95
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. J Clin Invest (2012) 0.95
Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci (2010) 0.94
Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1. Development (2010) 0.93
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res (2013) 0.93
IKK1 control of epidermal differentiation is modulated by notch signaling. Am J Pathol (2011) 0.93
Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am J Cancer Res (2012) 0.89
Disruption of prostate epithelial differentiation pathways and prostate cancer development. Front Oncol (2013) 0.89
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest (2013) 0.88
Epidermal p65/NF-κB signalling is essential for skin carcinogenesis. EMBO Mol Med (2014) 0.87
Back to the future with phenotypic screening. ACS Chem Neurosci (2014) 0.86
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS One (2014) 0.85
Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. Neuropathol Appl Neurobiol (2015) 0.84
Loss of Notch1 disrupts the barrier repair in the corneal epithelium. PLoS One (2013) 0.84
Development and homeostasis of the skin epidermis. Cold Spring Harb Perspect Biol (2012) 0.84
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (2015) 0.83
Targeting Notch to overcome radiation resistance. Oncotarget (2016) 0.82
Tumor-suppressor role of Notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological induction. Mol Cancer Ther (2014) 0.82
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. Cancer Cell (2016) 0.81
Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila) (2015) 0.81
No evidence for induction of key components of the Notch signaling pathway (Notch-1, Jagged-1) by treatment with UV-B, 1,25(OH)(2)D(3), and/or epigenetic drugs (TSA, 5-Aza) in human keratinocytes in vitro. Dermatoendocrinol (2012) 0.81
Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma. PLoS One (2012) 0.81
Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis. Blood (2011) 0.81
An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammation. PLoS One (2013) 0.80
Regulation of non-classical FGF1 release and FGF-dependent cell transformation by CBF1-mediated notch signaling. J Cell Physiol (2011) 0.80
Cell competition: winning out by losing notch. Cell Cycle (2015) 0.78
Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med (2014) 0.78
Cutaneous Notch signaling in health and disease. Cold Spring Harb Perspect Med (2013) 0.78
Targeting γ-secretase in breast cancer. Breast Cancer (Dove Med Press) (2012) 0.77
Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol (2015) 0.77
The role of barrier genes in epidermal malignancy. Oncogene (2016) 0.76
Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest (2016) 0.76
Stem cells behind the barrier. Int J Mol Sci (2013) 0.76
Epidermal polarity genes in health and disease. Cold Spring Harb Perspect Med (2014) 0.76
Whole exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma. Cancer Prev Res (Phila) (2016) 0.75
Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Mol Biol Cell (2015) 0.75
The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol (2016) 0.75
Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene (2016) 0.75
Progression of chronic kidney disease: too much cellular talk causes damage. Kidney Int (2016) 0.75
Notch as a tumour suppressor. Nat Rev Cancer (2017) 0.75
Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis. Cancer (2016) 0.75
Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas. BMC Cancer (2015) 0.75
Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia. Sci Rep (2016) 0.75
The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease. Sci Rep (2016) 0.75
FOXN1 transcription factor in epithelial growth and wound healing. Mol Cell Biol (2017) 0.75
Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression. Semin Cancer Biol (2017) 0.75
Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis. Exp Cell Res (2017) 0.75
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08
Putting tumours in context. Nat Rev Cancer (2001) 12.37
Stromal fibroblasts in cancer initiation and progression. Nature (2004) 11.69
Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer (2004) 9.68
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Tumor stroma and regulation of cancer development. Annu Rev Pathol (2006) 6.66
A single type of progenitor cell maintains normal epidermis. Nature (2007) 6.32
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell (2005) 5.79
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol (2007) 5.16
Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood (2000) 4.78
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29
Epidermal barrier formation and recovery in skin disorders. J Clin Invest (2006) 4.14
The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer (2007) 4.01
Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol (2006) 4.01
Patterned acquisition of skin barrier function during development. Development (1998) 3.88
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med (2005) 3.82
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51
Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol (2007) 3.51
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Notch and cancer: a double-edged sword. Cell Mol Life Sci (2007) 2.59
c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell (2000) 2.35
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol (2007) 2.02
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99
Polarized immune responses differentially regulate cancer development. Immunol Rev (2008) 1.95
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell (2004) 1.78
From gut homeostasis to cancer. Curr Mol Med (2006) 1.66
Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell (2004) 1.62
Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell (2007) 1.49
Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A (2004) 1.48
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res (2009) 1.38
Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1. J Clin Invest (2002) 1.34
C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9. Am J Pathol (2008) 1.22
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Res (1999) 1.19
Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding. Br J Cancer (1985) 1.06
Nonmelanoma skin cancer. Curr Treat Options Oncol (2002) 1.05
Mast cells and immunological skin diseases. Clin Rev Allergy Immunol (2007) 1.03
Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis (2006) 1.00
Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis. Carcinogenesis (2003) 0.98
Venous leg ulcers and squamous cell carcinoma: a large-scale epidemiological study. Br J Dermatol (1995) 0.83
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci (2003) 3.79
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Intramembrane proteolysis: theme and variations. Science (2004) 3.06
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
SnapShot: notch signaling pathway. Cell (2007) 1.63
Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell (2004) 1.62
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell (2005) 1.62
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med (2004) 1.60
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (2012) 1.29
Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (2009) 1.23
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci (2010) 1.21
rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol (2008) 1.21
Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun (2006) 1.21
The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int (2005) 1.20
A garden of Notch-ly delights. Development (2006) 1.19
Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci (2006) 1.17
Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Dev Biol (2003) 1.15
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest (2013) 1.13
Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol (2005) 1.13
The Notch transcription activation complex makes its move. Cell (2006) 1.12
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (2011) 1.10
Notch pathway is dispensable for adipocyte specification. Genesis (2004) 1.08
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev (2009) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Rep (2013) 1.06
Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal (2011) 1.05
The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci (2005) 1.04
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci (2009) 1.04
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet (2012) 1.02
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. J Neurochem (2005) 1.02
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. J Biol Chem (2009) 1.00
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One (2012) 0.98
Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A (2007) 0.93
Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol (2010) 0.91
Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res (2009) 0.91
The black box illuminated: signals and signaling. J Invest Dermatol (2011) 0.88
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (2013) 0.87
Epidermal ADAM17 is dispensable for notch activation. J Invest Dermatol (2013) 0.86
Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation (2009) 0.86
Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer Cell (2013) 0.85
In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS One (2013) 0.84
The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol (2013) 0.83
Chromatin-based mechanisms of renal epithelial differentiation. J Am Soc Nephrol (2011) 0.79
Murine vibrissae cultured in serum-free medium reinitiate anagen. J Invest Dermatol (2007) 0.78
Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harb Protoc (2010) 0.77
Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Curr Opin Genet Dev (2002) 0.76
Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods Mol Biol (2014) 0.76
A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry (2006) 0.75
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest (2016) 0.75
Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods Mol Biol (2014) 0.75
SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Mol Cell (2016) 0.75
Making new kidneys: On the road from science fiction to science fact. Curr Opin Organ Transplant (2016) 0.75
Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harb Protoc (2015) 0.75
Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun (2016) 0.75