Published in Aging (Albany NY) on December 10, 2009
ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One (2011) 1.16
The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci (2012) 1.14
Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med (2012) 1.12
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci (2010) 1.07
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Particulate matter exposure exacerbates high glucose-induced cardiomyocyte dysfunction through ROS generation. PLoS One (2011) 0.92
Growth factors, nutrient signaling, and cardiovascular aging. Circ Res (2012) 0.91
Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med (2011) 0.91
Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction. Dis Model Mech (2012) 0.91
Mouse models of PAK function. Cell Logist (2012) 0.89
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. Heart Vessels (2012) 0.88
Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice. Aging (Albany NY) (2012) 0.88
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One (2010) 0.84
IGF1 mRNA isoform expression in the cervix of HPV-positive women with pre-cancerous and cancer lesions. Exp Ther Med (2010) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
When is Sirt1 activity bad for dying neurons? Front Cell Neurosci (2013) 0.81
The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. J Biol Chem (2015) 0.81
Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy. J Am Heart Assoc (2014) 0.81
Surprising sirtuin crosstalk in the heart. Aging (Albany NY) (2010) 0.77
Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer. Contemp Oncol (Pozn) (2012) 0.77
Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction. Mediators Inflamm (2015) 0.76
Recombinant human growth hormone and insulin-like growth factor-1 do not affect mitochondrial derived highly reactive oxygen species production in peripheral blood mononuclear cells under conditions of substrate saturation in-vitro. Nutr Metab (Lond) (2016) 0.75
Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging. Oncotarget (2016) 0.75
Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target? Curr Pharm Des (2013) 0.75
Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration. Front Aging Neurosci (2017) 0.75
Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins. PLoS One (2017) 0.75
The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system. Cell Death Dis (2017) 0.75
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A (1998) 8.22
Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol (2003) 6.99
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest (2005) 5.53
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
Evolutionary medicine: from dwarf model systems to healthy centenarians? Science (2003) 4.31
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell (1993) 4.15
Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med (2004) 4.05
Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J (1991) 3.29
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes (2007) 3.20
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93
Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov (2008) 2.89
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J Biol Chem (2005) 2.73
Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension (2006) 2.59
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res (2008) 2.51
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem (2006) 2.42
Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A (1996) 2.34
Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart (2006) 2.28
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08
Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. J Clin Invest (1998) 1.96
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. J Am Coll Cardiol (2008) 1.95
IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes (2001) 1.92
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol (2005) 1.79
Role of apoptosis in cardiovascular disease. Apoptosis (2009) 1.74
Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol (2003) 1.62
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol Genomics (2006) 1.57
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2008) 1.39
Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. FASEB J (1999) 1.32
Enhancing repair of the mammalian heart. Circ Res (2007) 1.21
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation (2004) 1.21
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol (2006) 1.20
A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy. Trends Pharmacol Sci (2003) 1.14
Insulin-like growth factor I deficiency prolongs survival and antagonizes paraquat-induced cardiomyocyte dysfunction: role of oxidative stress. Rejuvenation Res (2007) 1.10
NAD(+), sirtuins, and cardiovascular disease. Curr Pharm Des (2009) 1.07
Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harb Symp Quant Biol (2002) 1.03
Effect of exercise and calorie restriction on biomarkers of aging in mice. Am J Physiol Regul Integr Comp Physiol (2008) 1.03
IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population. Eur J Endocrinol (2008) 0.98
Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. Am J Physiol Heart Circ Physiol (2008) 0.94
Positive inotropic and negative lusitropic effect of angiotensin II: intracellular mechanisms and second messengers. J Mol Cell Cardiol (2001) 0.94
Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. J Hypertens (2008) 0.92
Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1. Am J Physiol (1996) 0.84
Post-publication sharing of data and tools. Nature (2009) 4.46
The macro domain is an ADP-ribose binding module. EMBO J (2005) 4.07
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol (2007) 3.62
Splicing regulates NAD metabolite binding to histone macroH2A. Nat Struct Mol Biol (2005) 3.40
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A (2009) 3.21
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A (2009) 3.02
Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am J Physiol Heart Circ Physiol (2004) 2.84
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. J Cell Biol (2002) 2.76
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. J Cell Biol (2005) 2.61
Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab (2008) 2.34
Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest (2005) 2.24
Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest (2006) 2.13
Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res (2005) 2.12
MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01
Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis. Circ Res (2007) 1.83
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol (2005) 1.79
Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci U S A (2004) 1.79
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines. FASEB J (2007) 1.76
Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit Care Med (2010) 1.73
Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice. Dis Model Mech (2009) 1.72
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol (2007) 1.70
Models for financial sustainability of biological databases and resources. Database (Oxford) (2009) 1.64
Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res (2006) 1.63
A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development (2003) 1.51
Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res (2007) 1.50
The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Proc Natl Acad Sci U S A (2008) 1.50
Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res (2008) 1.50
An acetylation switch in p53 mediates holo-TFIID recruitment. Mol Cell (2007) 1.48
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol (2013) 1.47
Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature (2013) 1.47
The role of stem cells in skeletal and cardiac muscle repair. J Histochem Cytochem (2002) 1.44
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science (2009) 1.44
Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem (2004) 1.43
Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO J (2013) 1.40
Derive and conquer: sourcing and differentiating stem cells for therapeutic applications. Nat Rev Drug Discov (2008) 1.38
Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis. Mol Biol Cell (2010) 1.36
Developmental basis of evolutionary digit loss in the Australian lizard Hemiergis. J Exp Zool B Mol Dev Evol (2003) 1.35
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes. J Biol Chem (2004) 1.32
Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell (2013) 1.31
Regulation of muscle atrophy in aging and disease. Adv Exp Med Biol (2010) 1.30
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. Genome Biol (2007) 1.29
Revealing new mouse epicardial cell markers through transcriptomics. PLoS One (2010) 1.24
Sensing NAD metabolites through macro domains. Front Biosci (Landmark Ed) (2009) 1.23
Research funding. Sustaining the data and bioresource commons. Science (2010) 1.21
Enhancing repair of the mammalian heart. Circ Res (2007) 1.21
Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. Growth Horm IGF Res (2005) 1.21
The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi. Curr Biol (2007) 1.21
Different modes of hypertrophy in skeletal muscle fibers. J Cell Biol (2002) 1.21
The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Curr Opin Struct Biol (2011) 1.18
Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome. Proc Natl Acad Sci U S A (2009) 1.18
Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes. J Biol Chem (2006) 1.17
Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver. Dis Model Mech (2013) 1.15
Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circ Res (2009) 1.12
Cre recombinase resources for conditional mouse mutagenesis. Methods (2010) 1.12
Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A (2013) 1.11
ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. Mol Cell Biol (2007) 1.09
Finding and sharing: new approaches to registries of databases and services for the biomedical sciences. Database (Oxford) (2010) 1.08
Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice. Mol Ther (2004) 1.08
Effect of mechanical loading on three-dimensional cultures of embryonic stem cell-derived cardiomyocytes. Tissue Eng Part A (2008) 1.08
Expression of follistatin-related genes is altered in heart failure. Endocrinology (2008) 1.07
A metabolic throttle regulates the epigenetic state of rDNA. Cell (2008) 1.06
Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport. J Biol Chem (2010) 1.04
Beyond knockouts: cre resources for conditional mutagenesis. Mamm Genome (2012) 1.04
mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart. Aging Cell (2011) 1.04
The recognition and removal of cellular poly(ADP-ribose) signals. FEBS J (2013) 1.01
Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am J Pathol (2008) 1.01
NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. J Mol Med (Berl) (2008) 1.01
Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation. J Investig Med (2005) 1.00
E-peptides control bioavailability of IGF-1. PLoS One (2012) 1.00
A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol (2007) 0.99
Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circ Cardiovasc Genet (2013) 0.98
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Genes Dev (2011) 0.98
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. Structure (2013) 0.97
SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97
The neuroprotective effects of a locally acting IGF-1 isoform. Exp Gerontol (2006) 0.94
RNA Pol IV plays catch with Argonaute 4. Cell (2007) 0.93
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One (2011) 0.92
The future of regenerative therapy in patients with chronic heart failure. Nat Clin Pract Cardiovasc Med (2006) 0.92
Modular paths to 'decoding' and 'wiping' histone lysine methylation. Curr Opin Chem Biol (2007) 0.91
CAST-ChIP maps cell-type-specific chromatin states in the Drosophila central nervous system. Cell Rep (2013) 0.91
Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction. Dis Model Mech (2012) 0.91
Heme oxygenase-1 inhibits pro-oxidant induced hypertrophy in HL-1 cardiomyocytes. Exp Biol Med (Maywood) (2009) 0.91
Phenostat: visualization and statistical tool for analysis of phenotyping data. Mamm Genome (2007) 0.90
The 21-day postnatal rat ventricular cardiac muscle cell in culture as an experimental model to study adult cardiomyocyte gene expression. Mol Cell Biochem (2002) 0.90
Embryonic stem cells form an organized, functional cardiac conduction system in vitro. Am J Physiol Heart Circ Physiol (2004) 0.89
Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways. Mol Biol Cell (2005) 0.88
Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium. Biochem Biophys Res Commun (2011) 0.88
Myocardial regenerative properties of macrophage populations and stem cells. J Cardiovasc Transl Res (2012) 0.87
Genetic isolation of stem cell-derived pacemaker-nodal cardiac myocytes. Mol Cell Biochem (2013) 0.87
A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo. J Cell Sci (2010) 0.86