Published in Nucleic Acids Res on July 19, 2004
Higher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers. Biochemistry (2008) 1.04
2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Res (2007) 1.03
New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX. Nucleic Acids Res (2005) 1.00
Crystallographic studies of chemically modified nucleic acids: a backward glance. Chem Biodivers (2010) 0.86
Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines. Nucleic Acids Res (2005) 0.86
In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle. Nucleic Acids Res (2013) 0.85
Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine. Nucleic Acids Res (2005) 0.85
Synthesis and properties of 4'-ThioDNA: unexpected RNA-like behavior of 4'-ThioDNA. Nucleic Acids Res (2006) 0.84
Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability. Nucleic Acids Res (2009) 0.82
Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect. Nucleic Acids Res (2012) 0.81
RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Adv Drug Deliv Rev (2011) 0.80
Applications of aptamers in targeted imaging: state of the art. Curr Top Med Chem (2015) 0.79
Gene Silencing Using 4'-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response. Mol Ther Nucleic Acids (2016) 0.78
4-thiouridine induces dose-dependent reduction of oedema, leucocyte influx and tumour necrosis factor in lung inflammation. Clin Exp Immunol (2008) 0.78
Delivery systems for in vivo use of nucleic Acid drugs. Drug Target Insights (2007) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (1990) 35.96
Adaptive recognition by nucleic acid aptamers. Science (2000) 5.33
Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin Chem (1999) 5.22
Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem (2003) 3.67
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci U S A (2000) 3.04
RNA interference in mammalian cells by chemically-modified RNA. Biochemistry (2003) 2.62
Absorption and circular dichroism spectroscopy of nucleic acid duplexes and triplexes. Methods Enzymol (1995) 2.08
Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res (1991) 1.80
Selection and characterization of an RNA decoy for transcription factor NF-kappa B. Biochemistry (1999) 1.77
Oligonucleotide N3'-->P5' phosphoramidates. Proc Natl Acad Sci U S A (1995) 1.74
2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim Biophys Acta (1999) 1.73
Circular dichroism spectroscopy of DNA. Methods Enzymol (1992) 1.64
Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proc Natl Acad Sci U S A (2003) 1.55
Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages. Nucleic Acids Res (1993) 1.44
BNAs: novel nucleic acid analogs with a bridged sugar moiety. Chem Commun (Camb) (2002) 1.11
4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase. Nucleic Acids Res (1993) 1.09
LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets. Nucleosides Nucleotides Nucleic Acids (2001) 0.93
4'-Thio-RNA: synthesis of mixed base 4'-thio-oligoribonucleotides, nuclease resistance, and base pairing properties with complementary single and double strand. Antisense Res Dev (1995) 0.92
Conformational preorganization, hydration, and nucleic acid duplex stability. Antisense Nucleic Acid Drug Dev (1998) 0.92
Chemical engineering of RNase resistant and catalytically active hammerhead ribozymes. Bioorg Med Chem (1997) 0.79
Oligodeoxynucleotides having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines form stable hairpins. Biochemistry (2004) 0.78
Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts. Haematologica (2008) 2.69
Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet (2005) 1.70
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population. Mol Vis (2008) 1.61
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci U S A (2009) 1.51
Silencing of int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease. Cardiovasc Res (2011) 1.46
Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study. Leuk Res (2012) 1.42
Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells. Vet J (2012) 1.41
Is macrocytosis a favourable prognostic factor in myelodysplastic syndrome patients without increased blasts? Br J Haematol (2003) 1.39
Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Biochemistry (2003) 1.27
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J Immunol (2013) 1.19
Diagnostic utility of flow cytometry in low-grade myelodysplastic syndromes: a prospective validation study. Haematologica (2009) 1.16
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet (2005) 1.14
The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry (2003) 1.09
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Am J Pathol (2010) 1.09
New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four hydrogen bonds. J Am Chem Soc (2003) 1.08
Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci (2011) 1.08
Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. J Biochem (2002) 1.07
Association between IFNA genotype and the risk of sarcoidosis. Hum Genet (2004) 1.03
No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA. Bioconjug Chem (2003) 1.01
New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX. Nucleic Acids Res (2005) 1.00
Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair. Cancer Res (2008) 1.00
Total synthesis of caprazol, a core structure of the caprazamycin antituberculosis antibiotics. Angew Chem Int Ed Engl (2005) 0.99
Synthesis of 1,8-naphthyridine C-nucleosides and their base-pairing properties in oligodeoxynucleotides: thermally stable naphthyridine:imidazopyridopyrimidine base-pairing motifs. Angew Chem Int Ed Engl (2005) 0.99
RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells. FEBS Lett (2005) 0.99
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. Structure (2004) 0.97
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J (2013) 0.97
Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Jpn J Cancer Res (2002) 0.97
Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. Haematologica (2008) 0.96
A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. Drug Metab Dispos (2004) 0.94
Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes. Hum Mol Genet (2005) 0.94
Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors. J Med Chem (2011) 0.94
Total synthesis of (-)-muraymycin D2 and its epimer. J Org Chem (2010) 0.94
Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells. Mutat Res (2002) 0.93
Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety. J Am Chem Soc (2005) 0.93
Lattice corneal dystrophy type IV (p.Leu527Arg) is caused by a founder mutation of the TGFBI gene in a single Japanese ancestor. Invest Ophthalmol Vis Sci (2010) 0.92
Synthesis of caprazamycin analogues and their structure--activity relationship for antibacterial activity. J Org Chem (2007) 0.92
Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'- deoxyguanosine 5'-triphosphate). Mutat Res (2011) 0.92
Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation. Cancer Res (2005) 0.92
Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity. Biochemistry (2002) 0.91
Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium. Invest Ophthalmol Vis Sci (2002) 0.91
New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor. J Med Chem (2002) 0.90
Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridines. Nucleic Acids Res (2003) 0.89
Characterization of a novel metalloproteinase in Duvernoy's gland of Rhabdophis tigrinus tigrinus. J Toxicol Sci (2006) 0.89
Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. Am J Physiol Cell Physiol (2011) 0.89
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS One (2013) 0.88
Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J (2010) 0.88
Functional haplotypes of IL-12B are associated with childhood atopic asthma. J Allergy Clin Immunol (2005) 0.88
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther (2008) 0.88
Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC. Blood (2010) 0.88
The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice. J Control Release (2014) 0.88
In vitro selection of hairpin ribozymes activated with short oligonucleotides. Biochemistry (2002) 0.87
Synthesis of L-epi-capreomycidine derivatives via C-H amination. Org Lett (2011) 0.87
Perlecan-deficient mutation impairs corneal epithelial structure. Invest Ophthalmol Vis Sci (2012) 0.87
Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice. Int J Radiat Oncol Biol Phys (2007) 0.87
Unexpected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance. Nucleic Acids Res (2008) 0.86
Differences in epidemiology of MDS between Western and Eastern countries: Ethnic differences or environmental influence? Leuk Res (2006) 0.86
Structure-activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents. Bioorg Med Chem (2008) 0.86
A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes. J Biol Chem (2010) 0.86
2'/3'-O-peptidyl adenosine as a general base catalyst of its own external peptidyl transfer: implications for the ribosome catalytic mechanism. Chembiochem (2005) 0.86
Rolling circle amplification in a prokaryotic translation system using small circular RNA. Angew Chem Int Ed Engl (2013) 0.85
Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping. Biochemistry (2002) 0.85
In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle. Nucleic Acids Res (2013) 0.85
Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria. J Med Chem (2010) 0.85
Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D. J Am Chem Soc (2003) 0.85
Investigations toward the selection of fully-modified 4'-thioRNA aptamers: optimization of in vitro transcription steps in the presence of 4'-thioNTPs. Bioorg Med Chem (2008) 0.85
Chemistry of cyclic ADP-ribose and its analogs. Curr Med Chem (2004) 0.85
Study of modification pattern-RNAi activity relationships by using siRNAs modified with 4'-thioribonucleosides. Chembiochem (2007) 0.85
Amplification of 4'-thioDNA in the presence of 4'-thio-dTTP and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells. J Am Chem Soc (2007) 0.85
Mechanism of action of a new antitumor ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), differs from that of 5-fluorouracil. Oncol Rep (2007) 0.85
Synthesis and properties of 4'-ThioDNA: unexpected RNA-like behavior of 4'-ThioDNA. Nucleic Acids Res (2006) 0.84
Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents. J Org Chem (2003) 0.84
Selective recognition of unnatural imidazopyridopyrimidine:naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment. J Am Chem Soc (2009) 0.84
Involvement of plasminogen activator inhibitor-1 in the pathogenesis of atopic cataracts. Invest Ophthalmol Vis Sci (2012) 0.84
Atopic Glaucoma: Clinical and Pathophysiological Analysis. J Glaucoma (2015) 0.83
Monocyte chemotactic protein-1 levels in the vitreous of patients with proliferative vitreoretinopathy. Jpn J Ophthalmol (2002) 0.83
A novel anticancer ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells. Radiat Res (2004) 0.83
Development of a highly beta-selective ribosylation reaction without using neighboring group participation: total synthesis of (+)-caprazol, a core structure of caprazamycins. J Org Chem (2007) 0.83
Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population. Int Arch Allergy Immunol (2005) 0.83
Triazole-linked dumbbell oligodeoxynucleotides with NF-kappaB binding ability as potential decoy molecules. J Org Chem (2008) 0.83
Practical synthesis of 2'-deoxy-4'-thioribonucleosides: substrates for the synthesis of 4'-thioDNA. J Org Chem (2005) 0.82
Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability. Nucleic Acids Res (2009) 0.82
A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression. Mol Cancer (2011) 0.82
Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res Suppl (2002) 0.82
Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci (2009) 0.82