Published in Science on August 06, 2004
The sequence of the human genome. Science (2001) 101.55
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
A reversible posterior leukoencephalopathy syndrome. N Engl J Med (1996) 23.35
alpha-Synuclein locus triplication causes Parkinson's disease. Science (2003) 20.20
Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A (2008) 13.09
Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol (1982) 11.47
Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet (1994) 11.37
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99
A prognostic index in primary breast cancer. Br J Cancer (1982) 7.35
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J Exp Med (2001) 6.51
Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem (1995) 6.25
Comparison of HIV-antibody prevalence in patients consenting to and declining HIV-antibody testing in an STD clinic. JAMA (1988) 6.14
Neurological complications of pertussis inoculation. Arch Dis Child (1974) 6.12
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J Clin Invest (1971) 6.09
Reverse transcriptase template switching: a SMART approach for full-length cDNA library construction. Biotechniques (2001) 5.92
Smoking, smoking cessation, and major depression. JAMA (1990) 5.89
The incidence of consanguineous matings in Japan, with remarks on the estimation of comparative gene frequencies and the expected rate of appearance of induced recessive mutations. Am J Hum Genet (1949) 5.72
Communication failures in patient sign-out and suggestions for improvement: a critical incident analysis. Qual Saf Health Care (2005) 5.55
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev (1995) 5.53
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med (1998) 5.50
Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res (1999) 5.35
Condom effectiveness in reducing heterosexual HIV transmission. Cochrane Database Syst Rev (2002) 5.29
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature (1988) 5.11
Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther (1999) 4.65
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science (1992) 4.53
Activation of BPV-1 replication in vitro by the transcription factor E2. Nature (1991) 4.51
A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J Infect Dis (1998) 4.50
Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J Cell Biol (1978) 4.50
The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum Reprod (1998) 4.42
Personal view. Is it reality or an illusion that liquid-based cytology is better than conventional cervical smears? Cytopathology (2001) 4.40
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J Cell Biol (1999) 4.20
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol (1998) 4.13
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med (1995) 4.12
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol (2004) 4.12
Dependence on hypnotic drugs in general practice. Br Med J (1968) 3.88
Making self regulation credible. Through benchmarking, peer review, appraisal-and management. BMJ (1998) 3.84
Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment. Lancet (1983) 3.79
Population policy: will current programs succeed? Grounds for skepticism concerning the demographic effectiveness of family planning are considered. Science (1967) 3.55
An epidemiological study of disorders in late childhood and adolescence--I. Age- and gender-specific prevalence. J Child Psychol Psychiatry (1993) 3.54
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother (1992) 3.52
A randomised controlled trial comparing two schedules of antenatal visits: the antenatal care project. BMJ (1996) 3.50
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A (1995) 3.47
The use of a synthetic medium in the isolation of the somatic antigens of Bact. typhi-murium and Bact. typhosum. Biochem J (1940) 3.45
Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol (1998) 3.44
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med (1996) 3.41
The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B. Plant Cell (1997) 3.40
Multiple lentigenes syndrome. Am J Dis Child (1969) 3.39
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene. Science (1998) 3.39
Benign intracranial hypertension following corticosteroid withdrawal in childhood. Br Med J (1970) 3.38
Novel method for studying mRNA phenotypes in single or small numbers of cells. J Cell Biochem (1989) 3.30
Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues. Science (1984) 3.29
Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol (1997) 3.24
Uninsured and underserved: inequities in health care in the United States. Milbank Mem Fund Q Health Soc (1983) 3.16
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron (1999) 3.15
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood (1996) 3.14
Physicians' views on quality of care: a five-country comparison. Health Aff (Millwood) (2001) 3.00
The theory of change and response in modern demographic history. Popul Index (1963) 2.95
Infection of the surgical site after arthroplasty of the hip. J Bone Joint Surg Br (2005) 2.94
Mupirocin resistance. Lancet (1991) 2.88
Complications of coronary arteriography from the Collaborative Study of Coronary Artery Surgery (CASS). Circulation (1979) 2.87
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J (1996) 2.83
Pharmacologic paralysis and withdrawal of mechanical ventilation at the end of life. N Engl J Med (2000) 2.81
Are patients with abnormal cervical smears adequately managed? Br Med J (Clin Res Ed) (1984) 2.78
Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis (1997) 2.78
Growth in the use of antibiotics in the community in England and Scotland in 1980-93. BMJ (1996) 2.74
The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol (1997) 2.71
Cardiac Resuscitation. Ann Surg (1948) 2.70
Clearing the cataract backlog. Br J Ophthalmol (1987) 2.66
Technique for measuring hippocampal T2 relaxation time. AJNR Am J Neuroradiol (1997) 2.65
Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. Curr Biol (1999) 2.64
Insurance matters for low-income adults: results from a five-state survey. Health Aff (Millwood) (1997) 2.60
Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. J Clin Oncol (2001) 2.59
Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Science (2001) 2.58
Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study. BJOG (2012) 2.57
Effect of acetabular component orientation on recurrent dislocation, pelvic osteolysis, polyethylene wear, and component migration. J Arthroplasty (1998) 2.57
In vivo analysis of plant promoters and transcription factors by agroinfiltration of tobacco leaves. Plant J (2000) 2.57
T cell development in the adult murine thymus: changes in the expression of the surface antigens Ly2, L3T4 and B2A2 during development from early precursor cells to emigrants. Immunol Rev (1984) 2.53
Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969. Arch Intern Med (1971) 2.52
Adverse impact of surgical site infections in English hospitals. J Hosp Infect (2005) 2.51
Hereditary angioedema: its diagnostic and management perspectives. Am J Med (1990) 2.50
A habitable fluvio-lacustrine environment at Yellowknife Bay, Gale crater, Mars. Science (2013) 2.50
Leber's hereditary optic atrophy: a possible defect of cyanide metabolism. Clin Sci (1965) 2.44
Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens. Exp Parasitol (1970) 2.40
IgA deficiency, epilepsy, and phenytoin treatment. Lancet (1975) 2.40
Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc Natl Acad Sci U S A (1996) 2.39
Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg (2001) 2.38
Social phobia. Comorbidity and morbidity in an epidemiologic sample. Arch Gen Psychiatry (1992) 2.37
Angiographic prevalence of high-risk coronary artery disease in patient subsets (CASS). Circulation (1981) 2.36
Cytokinesis in eukaryotes: a mechanistic comparison. Curr Opin Cell Biol (1999) 2.36
Device-related sources of bacteraemia in English hospitals--opportunities for the prevention of hospital-acquired bacteraemia. J Hosp Infect (2003) 2.33
Methods for microelectrode-guided posteroventral pallidotomy. J Neurosurg (1996) 2.30
Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A (1999) 2.29
Granuloma annulare and human immunodeficiency virus infection. Arch Dermatol (1999) 2.26