Published in Diabetes on October 01, 2004
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab (2010) 1.43
Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy. Endocr Rev (2009) 1.22
A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol (2007) 1.06
Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice. PLoS One (2011) 1.05
Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant (2012) 0.98
The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol (2013) 0.97
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (2013) 0.96
Insulin-producing surrogate β-cells from embryonic stem cells: are we there yet? Mol Ther (2011) 0.94
PAX4 enhances beta-cell differentiation of human embryonic stem cells. PLoS One (2008) 0.93
Stem cell therapy to treat diabetes mellitus. Rev Diabet Stud (2009) 0.88
Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. J Biomed Sci (2012) 0.87
PDX1-engineered embryonic stem cell-derived insulin producing cells regulate hyperglycemia in diabetic mice. Transplant Res (2012) 0.85
Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro. PLoS One (2011) 0.84
Methods to assess stem cell lineage, fate and function. Adv Drug Deliv Rev (2010) 0.83
Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J Tissue Eng Regen Med (2012) 0.82
Insulin producing cells derived from embryonic stem cells: are we there yet? J Cell Physiol (2009) 0.82
Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation. PLoS One (2010) 0.82
Present and future cell therapies for pancreatic beta cell replenishment. World J Gastroenterol (2012) 0.81
Stem cell-based approaches for the treatment of diabetes. Stem Cells Int (2011) 0.81
High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells. Acta Pharmacol Sin (2010) 0.81
Generation of embryonic stem cells from mouse insulin I promoter-green fluorescent protein transgenic mice and characterization in a teratoma model. In Vitro Cell Dev Biol Anim (2008) 0.80
Derivation of Endodermal Progenitors From Pluripotent Stem Cells. J Cell Physiol (2015) 0.80
Stem cell-based strategies for the treatment of type 1 diabetes mellitus. Expert Opin Biol Ther (2010) 0.80
Current status of regeneration of pancreatic β-cells. J Diabetes Investig (2013) 0.79
Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.79
Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter. Cloning Stem Cells (2009) 0.79
Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PLoS One (2013) 0.78
Cellular therapies for type 1 diabetes. Horm Metab Res (2008) 0.77
Cell therapies for pancreatic beta-cell replenishment. Ital J Pediatr (2016) 0.76
Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia. PLoS One (2016) 0.76
Transplantation of insulin-producing cells to treat diabetic rats after 90% pancreatectomy. World J Gastroenterol (2015) 0.75
Diabetes treatment: A rapid review of the current and future scope of stem cell research. Saudi Pharm J (2013) 0.75
Role of mesenchymal stem cells on differentiation in steroid-induced avascular necrosis of the femoral head. Exp Ther Med (2016) 0.75
A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1. Hum Gene Ther Methods (2014) 0.75
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Properties of the reverse transcription reaction in mRNA quantification. Clin Chem (2004) 3.49
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15
Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature (2013) 2.85
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
Pericytes limit tumor cell metastasis. J Clin Invest (2006) 2.55
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Cdc42-mediated tubulogenesis controls cell specification. Cell (2009) 2.35
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell (2012) 2.33
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell Biol (2008) 2.04
Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel. Stem Cells Dev (2010) 2.02
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Stem cells. Setting standards for human embryonic stem cells. Science (2003) 1.95
Derivation, characterization, and differentiation of human embryonic stem cells. Stem Cells (2004) 1.89
Specifying pancreatic endocrine cell fates. Mech Dev (2006) 1.84
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev (2007) 1.81
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet (2011) 1.73
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res (2009) 1.72
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell (2012) 1.72
Expression of the GLP-1 receptor in mouse, rat, and human pancreas. J Histochem Cytochem (2008) 1.72
Pericytes: gatekeepers in tumour cell metastasis? J Mol Med (Berl) (2007) 1.69
Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res (2009) 1.67
Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn (2002) 1.61
Role of endothelial cells in early pancreas and liver development. Mech Dev (2003) 1.58
Array-A-Lizer: a serial DNA microarray quality analyzer. BMC Bioinformatics (2004) 1.56
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody. Endocrinology (2014) 1.53
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem J (2003) 1.52
Drosophila Knickkopf and Retroactive are needed for epithelial tube growth and cuticle differentiation through their specific requirement for chitin filament organization. Development (2006) 1.50
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes (2011) 1.47
Human embryonic stem cells. Methods Enzymol (2006) 1.41
Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol Med (2011) 1.38
mRNA expression profiling of laser microbeam microdissected cells from slender embryonic structures. Am J Pathol (2002) 1.37
The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. J Biol Chem (2002) 1.36
Elimination of damaged proteins during differentiation of embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.36
Facilitated expansion of human embryonic stem cells by single-cell enzymatic dissociation. Stem Cells (2007) 1.32
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. PLoS Genet (2012) 1.31
The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development (2004) 1.30
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem (2007) 1.28
Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex. J Comput Assist Tomogr (2012) 1.27
Derivation of a xeno-free human embryonic stem cell line. Stem Cells (2006) 1.26
IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol Immunother (2008) 1.22
FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells (2010) 1.21
Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes (2005) 1.21
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
Differentiating human embryonic stem cells express a unique housekeeping gene signature. Stem Cells (2007) 1.18
Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy. PLoS One (2012) 1.18
Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. J Physiol (2012) 1.18
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development (2005) 1.15
Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol (2005) 1.14
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol (2004) 1.14
FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. PLoS One (2009) 1.13
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven. PLoS One (2011) 1.11
Monitoring differentiation of human embryonic stem cells using real-time PCR. Stem Cells (2005) 1.11
Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn (2008) 1.11
Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med (2007) 1.10
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol (2007) 1.08
Growth-limiting role of endothelial cells in endoderm development. Dev Biol (2011) 1.08
Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. J Histochem Cytochem (2008) 1.08
Quantitative comparison of constitutive promoters in human ES cells. PLoS One (2010) 1.08
Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn (2003) 1.07
The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research. Nat Biotechnol (2005) 1.06
Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol (2002) 1.06
New insights into melanosome transport in vertebrate pigment cells. Int Rev Cell Mol Biol (2009) 1.06
Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One (2009) 1.05
Analysis of pancreatic endocrine development in GDF11-deficient mice. Dev Dyn (2006) 1.05
Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. J Biotechnol (2009) 1.05
Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr (2003) 1.05
Artificial three-dimensional niches deconstruct pancreas development in vitro. Development (2013) 1.04
In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol (2012) 1.02
Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes (2006) 1.02
Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scand J Gastroenterol (2005) 1.02
Mind bomb 1 is required for pancreatic β-cell formation. Proc Natl Acad Sci U S A (2012) 1.02
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity. Obes Res (2003) 1.01
Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. Hum Reprod (2008) 1.01
Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Histochem Cytochem (2003) 1.01
Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling. Stem Cells (2010) 1.00