Published in J Biol Chem on October 04, 2004
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res (2006) 1.95
Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem (2010) 1.61
Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. Am J Physiol Heart Circ Physiol (2010) 1.23
Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation (2011) 1.20
Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A (2011) 1.14
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment. Mol Genet Metab (2010) 1.03
High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway. Lipids Health Dis (2011) 0.98
Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor κB (NF-κB) pathway. J Biol Chem (2014) 0.95
Lipid metabolism and body composition in Gclm(-/-) mice. Toxicol Appl Pharmacol (2011) 0.95
Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism? J Lipids (2011) 0.92
Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism? Biology (Basel) (2015) 0.89
Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits. Mol Cell Proteomics (2013) 0.87
Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. PLoS One (2012) 0.87
S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system. Biochim Biophys Acta (2012) 0.87
Dietary methionine effects on plasma homocysteine and HDL metabolism in mice. J Nutr Biochem (2007) 0.86
A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial. FASEB J (2012) 0.86
Hydrogen sulfide and polysulfides as signaling molecules. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.85
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One (2013) 0.84
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency. J Bone Miner Res (2015) 0.82
Homocysteine inhibits hepatocyte proliferation via endoplasmic reticulum stress. PLoS One (2013) 0.82
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles. BMC Genomics (2013) 0.82
Hepatocyte proliferation during liver regeneration is impaired in mice with methionine diet-induced hyperhomocysteinemia. Am J Pathol (2010) 0.80
Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3. Am J Pathol (2011) 0.80
Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease? Oxid Med Cell Longev (2015) 0.79
Use of serum homocysteine to predict cardiovascular disease in Korean men with or without metabolic syndrome. J Korean Med Sci (2012) 0.79
Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice. J Biol Chem (2011) 0.78
Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology. J Pathol (2015) 0.78
Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget (2015) 0.77
Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. Sci Rep (2016) 0.77
2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice. FEBS Open Bio (2015) 0.75
Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population. Lipids Health Dis (2017) 0.75
Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study. Nutr J (2016) 0.75
Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus. Nutr Res Pract (2017) 0.75
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A (2007) 5.36
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal (2009) 3.44
Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J Biochem (2009) 3.25
Hydrogen sulfide protects neurons from oxidative stress. FASEB J (2004) 3.22
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J (2004) 2.59
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res (2007) 2.43
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest (2004) 2.36
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet (2003) 2.24
Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid Redox Signal (2010) 2.19
Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun (2009) 2.08
Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol (2002) 2.06
A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid Redox Signal (2009) 1.98
Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron (2002) 1.95
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nat Cell Biol (2007) 1.81
Hydrogen sulfide protects HT22 neuronal cells from oxidative stress. Antioxid Redox Signal (2006) 1.73
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2007) 1.70
Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. Gastroenterology (2006) 1.66
Polysulfides are possible H2S-derived signaling molecules in rat brain. FASEB J (2013) 1.62
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A (2012) 1.50
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res (2006) 1.48
The role of cytokines and trophic factors in epiretinal membranes: involvement of signal transduction in glial cells. Prog Retin Eye Res (2005) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Hydrogen sulfide induces calcium waves in astrocytes. FASEB J (2004) 1.43
Development of a highly selective fluorescence probe for hydrogen sulfide. J Am Chem Soc (2011) 1.43
Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice. Antioxid Redox Signal (2012) 1.42
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol (2005) 1.38
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Biochem J (2011) 1.38
Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J (2005) 1.36
L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes (2006) 1.36
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun (2013) 1.35
Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. J Am Coll Cardiol (2008) 1.33
Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun (2002) 1.32
Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta (2002) 1.30
Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxid Redox Signal (2005) 1.29
Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neurosci Res (2007) 1.27
Retracted Hydrogen sulfide is produced in response to neuronal excitation. J Neurosci (2002) 1.25
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am J Pathol (2006) 1.22
Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovasc Res (2005) 1.22
Cystathionine beta-synthase is enriched in the brains of Down's patients. Biochem Biophys Res Commun (2005) 1.20
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res (2008) 1.18
MOCA induces membrane spreading by activating Rac1. J Biol Chem (2004) 1.16
Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx. J Biol Chem (2011) 1.16
Spectroscopic visualization of vortex flows using dye-containing nanofibers. Angew Chem Int Ed Engl (2007) 1.15
In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim Biophys Acta (2002) 1.12
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics (2009) 1.12
Hemodynamic forces regulate mural macrophage infiltration in experimental aortic aneurysms. Exp Mol Pathol (2004) 1.11
Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett (2013) 1.09
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB J (2003) 1.08
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes. J Neurosci (2007) 1.08
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A (2010) 1.07
A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase. J Biol Chem (2002) 1.06
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat Commun (2011) 1.06
Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice. Glia (2005) 1.05
Clinical outcome and complications of temporary inferior vena cava filter placement. J Vasc Surg (2006) 1.04
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population. Hum Mutat (2004) 1.03
Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly. J Neurosci (2012) 1.02
Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS One (2011) 1.02
Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Dev Biol (2005) 1.01
Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na+/K+-ATPase via actin depolymerization. Mol Cell Biol (2008) 1.00
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med (2010) 1.00
Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose. FEBS Lett (2008) 1.00
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci (2002) 0.99
p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer. J Surg Oncol (2003) 0.98
Spontaneous mesenteric hemorrhage associated with Ehlers-Danlos syndrome. J Gastrointest Surg (2006) 0.97
Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho. Mol Biol Cell (2002) 0.96
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol (2006) 0.95
Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron (2002) 0.95
Expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma. Anticancer Res (2005) 0.94
Continuous periaortic infusion improves doxycycline efficacy in experimental aortic aneurysms. J Vasc Surg (2004) 0.93
Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body. Anat Embryol (Berl) (2004) 0.93
Determination of oxidized and reduced nicotinamide adenine dinucleotide in cell monolayers using a single extraction procedure and a spectrophotometric assay. Anal Biochem (2005) 0.92
Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells. Jpn J Ophthalmol (2008) 0.92
Role of cytokines and trophic factors in the pathogenesis of diabetic retinopathy. Curr Diabetes Rev (2005) 0.92
Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum Mol Genet (2008) 0.91
Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment. Graefes Arch Clin Exp Ophthalmol (2004) 0.91
Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium. Invest Ophthalmol Vis Sci (2002) 0.91
Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. Cancer Lett (2011) 0.91
Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients. Neurosci Lett (2006) 0.91
Functional imaging of gustatory perception and imagery: "top-down" processing of gustatory signals. Neuroimage (2004) 0.90
Role of neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo. Invest Ophthalmol Vis Sci (2005) 0.90
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment. Graefes Arch Clin Exp Ophthalmol (2005) 0.90
Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure. Circ J (2006) 0.90
Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest Ophthalmol Vis Sci (2011) 0.90
Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells. Biochem Biophys Res Commun (2010) 0.89
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur J Neurosci (2008) 0.89
Involvement of p27KIP1 in the proliferation of the developing corneal endothelium. Invest Ophthalmol Vis Sci (2004) 0.89
Surgical result of critical limb ischemia due to tibial arterial occlusion in patients with systemic scleroderma. J Vasc Surg (2009) 0.88
Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons. Exp Cell Res (2003) 0.88