Published in Mol Cell Proteomics on July 23, 2013
Systems Medicine: from molecular features and models to the clinic in COPD. J Transl Med (2014) 0.84
Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med (2015) 0.83
Reconstruction of the experimentally supported human protein interactome: what can we learn? BMC Syst Biol (2013) 0.79
Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis. PeerJ (2016) 0.77
Network science meets respiratory medicine for OSAS phenotyping and severity prediction. PeerJ (2017) 0.75
Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies. PLoS One (2017) 0.75
Using network clustering to predict copy number variations associated with health disparities. PeerJ (2015) 0.75
Finding directionality and gene-disease predictions in disease associations. BMC Syst Biol (2015) 0.75
Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes. Sci Rep (2016) 0.75
Next-generation gene discovery for variants of large impact on lipid traits. Curr Opin Lipidol (2015) 0.75
A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76
BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics (2005) 24.04
From molecular to modular cell biology. Nature (1999) 23.51
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97
Network medicine: a network-based approach to human disease. Nat Rev Genet (2011) 14.07
Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics (2002) 12.88
The IntAct molecular interaction database in 2010. Nucleic Acids Res (2009) 9.85
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39
MINT, the molecular interaction database: 2009 update. Nucleic Acids Res (2009) 7.19
Walking the interactome for prioritization of candidate disease genes. Am J Hum Genet (2008) 7.03
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet (2009) 5.98
The Malmo Diet and Cancer Study. Design and feasibility. J Intern Med (1993) 5.35
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
A dynamic network approach for the study of human phenotypes. PLoS Comput Biol (2009) 3.62
The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci U S A (2008) 3.41
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res (2011) 2.89
Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet (2009) 2.31
Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab (2009) 2.00
The power of protein interaction networks for associating genes with diseases. Bioinformatics (2010) 1.96
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res (2006) 1.95
Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 1.94
Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease. Circ Cardiovasc Genet (2010) 1.86
Identifying regulatory subnetworks for a set of genes. Mol Cell Proteomics (2005) 1.48
Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases. Nucleic Acids Res (2007) 1.43
Improving disease gene prioritization using the semantic similarity of Gene Ontology terms. Bioinformatics (2010) 1.37
CANDID: a flexible method for prioritizing candidate genes for complex human traits. Genet Epidemiol (2008) 1.36
Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. J Biol Chem (2004) 1.28
Stroke registry in Malmö, Sweden. Stroke (1992) 1.17
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes. Genet Epidemiol (2011) 1.08
Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study. Mol Med (2011) 1.07
GenRev: exploring functional relevance of genes in molecular networks. Genomics (2011) 1.07
Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. J Lipid Res (2010) 1.03
Looking at cerebellar malformations through text-mined interactomes of mice and humans. PLoS Comput Biol (2009) 0.95
Influence of 699C-->T and 1080C-->T polymorphisms of the cystathionine beta-synthase gene on plasma homocysteine levels. Clin Genet (2000) 0.91
Prediction of human disease-related gene clusters by clustering analysis. Int J Biol Sci (2011) 0.88
Genes to diseases (G2D) computational method to identify asthma candidate genes. PLoS One (2008) 0.86
Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia: lipid metabolism in cystathionine beta-synthase deficiency. Atherosclerosis (2010) 0.81
Deletion of the FHL2 gene attenuates the formation of atherosclerotic lesions after a cholesterol-enriched diet. Life Sci (2010) 0.81
Genome-wide association studies of plasma lipids: have we reached the limit? Arterioscler Thromb Vasc Biol (2010) 0.77
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Understanding individual human mobility patterns. Nature (2008) 29.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
Network medicine: a network-based approach to human disease. Nat Rev Genet (2011) 14.07
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Limits of predictability in human mobility. Science (2010) 11.89
Drug-target network. Nat Biotechnol (2007) 11.15
High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
Controllability of complex networks. Nature (2011) 9.09
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell (2006) 8.61
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Quantifying social group evolution. Nature (2007) 7.28
A universal model for mobility and migration patterns. Nature (2012) 7.18
Interactome networks and human disease. Cell (2011) 7.16
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet (2010) 6.07
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
Modeling bursts and heavy tails in human dynamics. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 5.49
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Quantifying long-term scientific impact. Science (2013) 5.18
Understanding the spreading patterns of mobile phone viruses. Science (2009) 5.08
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Hierarchical organization in complex networks. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 4.80
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Functional and topological characterization of protein interaction networks. Proteomics (2004) 4.57
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes (2006) 4.36
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature (2012) 4.35
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet (2007) 4.09
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Human dynamics: Darwin and Einstein correspondence patterns. Nature (2005) 3.89
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet (2005) 3.86
Network medicine--from obesity to the "diseasome". N Engl J Med (2007) 3.83
Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science (2011) 3.72
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology (2009) 3.67
Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nat Biotechnol (2007) 3.65
A dynamic network approach for the study of human phenotypes. PLoS Comput Biol (2009) 3.62
Network link prediction by global silencing of indirect correlations. Nat Biotechnol (2013) 3.27
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Geographic constraints on social network groups. PLoS One (2011) 3.08
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet (2009) 3.07
Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol Sci (2003) 2.99
Genetic prediction of future type 2 diabetes. PLoS Med (2005) 2.98
Systems biology. Life's complexity pyramid. Science (2002) 2.98
Ranking stability and super-stable nodes in complex networks. Nat Commun (2011) 2.67
Collective response of human populations to large-scale emergencies. PLoS One (2011) 2.48
Scale-free networks. Sci Am (2003) 2.44
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Two degrees of separation in complex food webs. Proc Natl Acad Sci U S A (2002) 2.43
Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery. Eur J Cardiothorac Surg (2011) 2.41
Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network. BMC Bioinformatics (2004) 2.41
Observability of complex systems. Proc Natl Acad Sci U S A (2013) 2.35
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet (2005) 2.32
Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology (2007) 2.31
The impact of cellular networks on disease comorbidity. Mol Syst Biol (2009) 2.23
Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms. Atherosclerosis (2011) 2.22
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Halting viruses in scale-free networks. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 2.19
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18
Mortality in acute type A aortic dissection: validation of the Penn classification. Ann Thorac Surg (2011) 2.15
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr (2009) 2.13
Universal features of correlated bursty behaviour. Sci Rep (2012) 2.10
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes (2007) 2.08
Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol Appl Pharmacol (2003) 1.99
Control centrality and hierarchical structure in complex networks. PLoS One (2012) 1.97
Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration. Behav Brain Res (2004) 1.95
Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease. Circ Cardiovasc Genet (2010) 1.86
Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb Vasc Biol (2005) 1.85
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol (2009) 1.83
Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction. Circ Res (2005) 1.82
In silico detection of sequence variations modifying transcriptional regulation. PLoS Comput Biol (2007) 1.82
Predicting synthetic rescues in metabolic networks. Mol Syst Biol (2008) 1.82
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet (2010) 1.79
Transcription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network. Genome Res (2007) 1.79
Distribution of node characteristics in complex networks. Proc Natl Acad Sci U S A (2007) 1.79
New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet (2012) 1.79
Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation (2011) 1.78
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects. Arterioscler Thromb Vasc Biol (2011) 1.78
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75