Published in EMBO J on October 21, 2004
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PLoS Biol (2006) 2.71
Membrane bending by protein-protein crowding. Nat Cell Biol (2012) 2.27
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. J Biol Chem (2009) 1.89
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A (2006) 1.85
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell (2008) 1.75
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell (2013) 1.68
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J (2007) 1.60
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54
Bending a membrane: how clathrin affects budding. Proc Natl Acad Sci U S A (2006) 1.53
Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size. Mol Biol Cell (2011) 1.41
Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol (2014) 1.41
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol (2010) 1.35
Role of HRB in clathrin-dependent endocytosis. J Biol Chem (2008) 1.28
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol (2012) 1.21
The aftiphilin/p200/gamma-synergin complex. Mol Biol Cell (2005) 1.19
Ubiquitin binds to and regulates a subset of SH3 domains. Mol Cell (2007) 1.19
Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci U S A (2007) 1.17
HOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles. Mol Biol Cell (2009) 1.16
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proc Natl Acad Sci U S A (2005) 1.16
AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis. Elife (2013) 1.11
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J Cell Biol (2005) 1.07
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J (2007) 1.05
The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. Mol Biol Cell (2008) 1.05
Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting. Mol Biol Cell (2007) 1.02
Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis. PLoS Comput Biol (2010) 0.99
ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic (2008) 0.98
ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol (2011) 0.94
Systems biology and physical biology of clathrin-mediated endocytosis. Integr Biol (Camb) (2011) 0.94
Arrestins as adaptors for ubiquitination in endocytosis and sorting. EMBO Rep (2008) 0.93
The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem (2010) 0.93
Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. EMBO J (2008) 0.91
FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. Mol Biol Cell (2012) 0.90
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. J Biol Chem (2009) 0.89
The NECAP PHear domain increases clathrin accessory protein binding potential. EMBO J (2007) 0.88
The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis. Mol Biol Cell (2012) 0.86
Stochastic model of clathrin-coated pit assembly. Biophys J (2012) 0.85
NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. PLoS Biol (2013) 0.84
Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms. Biomed Res Int (2014) 0.83
Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation. PLoS One (2012) 0.82
How do disordered regions achieve comparable functions to structured domains? Protein Sci (2015) 0.81
Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells. J Biol Chem (2012) 0.80
Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast. PLoS One (2012) 0.80
Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. Dev Cell (2016) 0.80
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease. Biochem Soc Trans (2016) 0.79
Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain. Sci Rep (2016) 0.79
Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2. J Cell Biol (2016) 0.79
Dynamics of clathrin-mediated endocytosis and its requirement for organelle biogenesis in Dictyostelium. J Cell Sci (2012) 0.79
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. BMC Cell Biol (2008) 0.79
The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis. Membranes (Basel) (2014) 0.78
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol (2017) 0.77
Conservation and divergence within the clathrin interactome of Trypanosoma cruzi. Sci Rep (2016) 0.76
Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia. PLoS Pathog (2016) 0.76
Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. J Biol Chem (2015) 0.76
Evolutionary Changes on the Way to Clathrin-Mediated Endocytosis in Animals. Genome Biol Evol (2016) 0.75
Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES. J Biol Chem (2016) 0.75
Inhibition of endocytic pathways impacts cytomegalovirus maturation. Sci Rep (2017) 0.75
Structure of Golgi transport proteins. Cold Spring Harb Perspect Biol (2011) 0.75
Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin. Traffic (2016) 0.75
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. Elife (2017) 0.75
Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell. J Cell Biol (2017) 0.75
Regulated portals of entry into the cell. Nature (2003) 15.33
Curvature of clathrin-coated pits driven by epsin. Nature (2002) 8.03
Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol (2003) 6.35
Accessory factors in clathrin-dependent synaptic vesicle endocytosis. Nat Rev Neurosci (2000) 4.72
Biological basket weaving: formation and function of clathrin-coated vesicles. Annu Rev Cell Dev Biol (2001) 4.72
Clathrin. Annu Rev Biochem (2000) 4.20
Purification and properties of 100-kd proteins from coated vesicles and their reconstitution with clathrin. EMBO J (1984) 3.02
A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature (1995) 2.98
A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Cell (1999) 2.65
Role of phosphorylation in regulation of the assembly of endocytic coat complexes. Science (1998) 2.60
Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. J Cell Biol (1992) 2.59
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals. Curr Biol (1998) 2.21
Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem (1996) 2.16
EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J Cell Biol (2003) 2.16
Deep-etch visualization of proteins involved in clathrin assembly. J Cell Biol (1988) 1.98
Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure (2002) 1.89
Clathrin-mediated endocytosis: membrane factors pull the trigger. Trends Cell Biol (2001) 1.86
Unusual structural organization of the endocytic proteins AP180 and epsin 1. J Biol Chem (2001) 1.65
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller. Nat Struct Mol Biol (2004) 1.59
Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. J Biol Chem (2003) 1.59
The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. J Biol Chem (1999) 1.49
Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nat Struct Biol (2003) 1.36
Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. J Biol Chem (2004) 1.34
Structural basis for binding of accessory proteins by the appendage domain of GGAs. Nat Struct Biol (2003) 1.32
Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin. Proc Natl Acad Sci U S A (2004) 1.27
Endocytosis and vesicle trafficking. Curr Opin Struct Biol (2002) 1.26
Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network. Mol Biol Cell (2003) 1.24
Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Mol Biol Cell (2003) 1.21
Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. EMBO Rep (2003) 1.14
Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. EMBO J (2004) 1.03
A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170. J Biol Chem (2003) 1.00
Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences. Biochemistry (2001) 0.97
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science (2003) 12.60
Mechanisms of endocytosis. Annu Rev Biochem (2009) 10.07
Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature (2005) 10.04
Genomic analysis of regulatory network dynamics reveals large topological changes. Nature (2004) 9.32
The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol (2004) 8.58
Curvature of clathrin-coated pits driven by epsin. Nature (2002) 8.03
Molecular signatures of G-protein-coupled receptors. Nature (2013) 5.19
Mechanism of endophilin N-BAR domain-mediated membrane curvature. EMBO J (2006) 4.80
How synaptotagmin promotes membrane fusion. Science (2007) 4.46
Gene regulatory network growth by duplication. Nat Genet (2004) 3.79
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol (2004) 3.76
Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet (2011) 3.73
Mechanisms of membrane fusion: disparate players and common principles. Nat Rev Mol Cell Biol (2008) 3.70
Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. Structure (2007) 3.67
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell (2010) 3.60
Synthetic genetic polymers capable of heredity and evolution. Science (2012) 3.59
Tight regulation of unstructured proteins: from transcript synthesis to protein degradation. Science (2008) 3.48
Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res (2005) 3.36
Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell (2012) 3.26
The hydrophobic insertion mechanism of membrane curvature generation by proteins. Biophys J (2008) 2.98
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J (2011) 2.97
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature (2007) 2.96
FCHo proteins are nucleators of clathrin-mediated endocytosis. Science (2010) 2.93
Integrating molecular and network biology to decode endocytosis. Nature (2007) 2.73
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PLoS Biol (2006) 2.71
The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man. Cancer Cell (2012) 2.59
COP and clathrin-coated vesicle budding: different pathways, common approaches. Curr Opin Cell Biol (2004) 2.49
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Mol Cell (2008) 2.45
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell (2006) 2.38
Comprehensive analysis of combinatorial regulation using the transcriptional regulatory network of yeast. J Mol Biol (2006) 2.36
Membrane bending by protein-protein crowding. Nat Cell Biol (2012) 2.27
Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling. Proc Natl Acad Sci U S A (2006) 2.25
BAR domains and membrane curvature: bringing your curves to the BAR. Biochem Soc Symp (2005) 2.20
Arf family GTP loading is activated by, and generates, positive membrane curvature. Biochem J (2008) 2.20
New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Rep (2007) 2.17
EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J Cell Biol (2003) 2.16
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12
Mediation, modulation, and consequences of membrane-cytoskeleton interactions. Annu Rev Biophys (2008) 2.07
Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. J Biol Chem (2003) 2.03
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks. Mol Cell (2012) 2.02
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17. Biochem J (2010) 1.93
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85
High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes. Nucleic Acids Res (2007) 1.80
Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc Natl Acad Sci U S A (2002) 1.78
Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells. Neuron (2005) 1.76
Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol (2009) 1.73
Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. Nat Cell Biol (2013) 1.72
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol (2011) 1.72
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. EMBO J (2011) 1.72
Protein-driven membrane stresses in fusion and fission. Trends Biochem Sci (2010) 1.69
Statistical analysis of domains in interacting protein pairs. Bioinformatics (2004) 1.64
Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes. Dev Cell (2004) 1.62
The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway. Curr Biol (2008) 1.62
Interplay between gene expression noise and regulatory network architecture. Trends Genet (2012) 1.61
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. Curr Opin Struct Biol (2013) 1.61
Exome sequencing of prostate cancer supports the hypothesis of independent tumour origins. Eur Urol (2012) 1.60
Conservation of gene co-regulation in prokaryotes and eukaryotes. Trends Biotechnol (2002) 1.55
ChIPping away at gene regulation. EMBO Rep (2008) 1.54
Structural basis for the nuclear import of the human androgen receptor. J Cell Sci (2008) 1.53
Uncovering a hidden distributed architecture behind scale-free transcriptional regulatory networks. J Mol Biol (2006) 1.52
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLoS One (2015) 1.48
Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells. J Biol Chem (2004) 1.48
Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission. Nature (2005) 1.46
Whole genome sequencing highlights genetic changes associated with laboratory domestication of C. elegans. PLoS One (2010) 1.44
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell (2008) 1.42
LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res (2009) 1.41
The rules of disorder or why disorder rules. Prog Biophys Mol Biol (2009) 1.39
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci (2005) 1.38
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers. EMBO J (2011) 1.33
The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA. Cell Cycle (2006) 1.32
O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells. Cancer Res (2013) 1.31
Dissecting the expression dynamics of RNA-binding proteins in posttranscriptional regulatory networks. Proc Natl Acad Sci U S A (2009) 1.30
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol (2010) 1.30
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Structure (2002) 1.27
Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission. J Biol Chem (2013) 1.26
Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation. J Biol Chem (2010) 1.25
Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (2008) 1.25
A time-invariant principle of genome evolution. Proc Natl Acad Sci U S A (2010) 1.24