Published in Cell on November 12, 2004
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Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol (2007) 2.32
Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol (2008) 2.23
A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe (2007) 2.17
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest (2009) 1.78
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52
Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol (2005) 1.44
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40
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Tick salivary compounds: their role in modulation of host defences and pathogen transmission. Front Cell Infect Microbiol (2013) 1.31
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. J Exp Med (2007) 1.29
Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog (2007) 1.24
Exploring the mialome of ticks: an annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae). BMC Genomics (2008) 1.24
A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity. PLoS Pathog (2009) 1.24
Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector. Infect Immun (2008) 1.21
Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. J Clin Invest (2010) 1.21
The pathogenesis of lyme neuroborreliosis: from infection to inflammation. Mol Med (2008) 1.20
Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host Microbe (2014) 1.19
Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity. PLoS One (2012) 1.19
Exploring the midgut transcriptome of Phlebotomus papatasi: comparative analysis of expression profiles of sugar-fed, blood-fed and Leishmania-major-infected sandflies. BMC Genomics (2007) 1.19
BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle. J Infect Dis (2009) 1.18
Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease. Infect Immun (2007) 1.17
Gene silencing of the tick protective antigens, Bm86, Bm91 and subolesin, in the one-host tick Boophilus microplus by RNA interference. Int J Parasitol (2006) 1.17
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. J Exp Med (2006) 1.17
A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell (2010) 1.17
BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts. J Infect Dis (2010) 1.16
The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol (2012) 1.16
Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles. Vet Res (2009) 1.14
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14
Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin. Parasitol Res (2006) 1.13
Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector. Future Microbiol (2013) 1.12
A cysteine protease is critical for Babesia spp. transmission in Haemaphysalis ticks. PLoS Pathog (2008) 1.11
Total, membrane, and immunogenic proteomes of macrophage- and tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods. Infect Immun (2008) 1.07
The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun (2011) 1.07
Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens. Infect Immun (2005) 1.05
Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. PLoS One (2008) 1.05
Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. PLoS Pathog (2011) 1.05
Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi. J Bacteriol (2007) 1.04
Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infect Immun (2007) 1.03
Illuminating the roles of the Borrelia burgdorferi adhesins. Trends Microbiol (2013) 1.03
Evolving models of Lyme disease spirochete gene regulation. Wien Klin Wochenschr (2006) 1.02
Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs. Vaccine (2005) 1.01
Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. J Infect Dis (2008) 1.00
Who is the BosR around here anyway? Mol Microbiol (2009) 1.00
Borrelia burgdorferi regulates expression of complement regulator-acquiring surface protein 1 during the mammal-tick infection cycle. Infect Immun (2005) 0.98
Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A. Proc Natl Acad Sci U S A (2007) 0.97
Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol (2012) 0.97
RNA interference screening in ticks for identification of protective antigens. Parasitol Res (2005) 0.96
Translocation of Borrelia burgdorferi surface lipoprotein OspA through the outer membrane requires an unfolded conformation and can initiate at the C-terminus. Mol Microbiol (2010) 0.94
Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog (2013) 0.93
Prevention of lyme disease and other tick-borne infections. Infect Dis Clin North Am (2008) 0.93
Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol Microbiol (2008) 0.93
Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect Immun (2008) 0.93
Synergistic effect of silencing the expression of tick protective antigens 4D8 and Rs86 in Rhipicephalus sanguineus by RNA interference. Parasitol Res (2006) 0.93
Methods for rapid transfer and localization of lyme disease pathogens within the tick gut. J Vis Exp (2011) 0.92
Transmission dynamics of Borrelia turicatae from the arthropod vector. PLoS Negl Trop Dis (2014) 0.92
Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation. PLoS One (2011) 0.92
Transmission-blocking antibodies against mosquito C-type lectins for dengue prevention. PLoS Pathog (2014) 0.92
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Surface localization determinants of Borrelia OspC/Vsp family lipoproteins. J Bacteriol (2011) 0.91
Proteolysis of BB0323 results in two polypeptides that impact physiologic and infectious phenotypes in Borrelia burgdorferi. Mol Microbiol (2013) 0.91
Antialarmin effect of tick saliva during the transmission of Lyme disease. Infect Immun (2010) 0.91
Motor rotation is essential for the formation of the periplasmic flagellar ribbon, cellular morphology, and Borrelia burgdorferi persistence within Ixodes scapularis tick and murine hosts. Infect Immun (2015) 0.91
Hard tick factors implicated in pathogen transmission. PLoS Negl Trop Dis (2014) 0.90
Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2009) 0.90
Absence of Borrelia spp., Candidatus Neoehrlichia mikurensis, and Anaplasma phagocytophilum in questing adult Dermacentor reticulatus ticks. Parasitol Res (2012) 0.90
Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine. Vaccine (2011) 0.89
Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi. J Bacteriol (2007) 0.89
Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions. Trends Parasitol (2015) 0.89
Genome-wide screen for temperature-regulated genes of the obligate intracellular bacterium, Rickettsia typhi. BMC Microbiol (2008) 0.89
Tick vaccines and the control of tick-borne pathogens. Front Cell Infect Microbiol (2013) 0.88
The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi. BMC Microbiol (2010) 0.88
Interaction of the Lyme disease spirochete with its tick vector. Cell Microbiol (2016) 0.88
Manganese and zinc regulate virulence determinants in Borrelia burgdorferi. Infect Immun (2013) 0.88
A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector. J Biol Chem (2014) 0.87
BBK07, a dominant in vivo antigen of Borrelia burgdorferi, is a potential marker for serodiagnosis of Lyme disease. Clin Vaccine Immunol (2009) 0.86
Infectivity of the highly transformable BBE02- lp56- mutant of Borrelia burgdorferi, the Lyme disease spirochete, via ticks. Infect Immun (2006) 0.86
Functional genomics tool: gene silencing in Ixodes scapularis eggs and nymphs by electroporated dsRNA. BMC Biotechnol (2010) 0.86
Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease. Infect Immun (2008) 0.86
A delicate interplay of structure, dynamics, and thermodynamics for function: a high pressure NMR study of outer surface protein A. Biophys J (2012) 0.85
Molecular characterization of Ehrlichia interactions with tick cells and macrophages. Front Biosci (Landmark Ed) (2009) 0.85
Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi. J Bacteriol (2010) 0.83
Tick capillary feeding for the study of proteins involved in tick-pathogen interactions as potential antigens for the control of tick infestation and pathogen infection. Parasit Vectors (2014) 0.82
Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi. PLoS One (2015) 0.81
Design and development of a novel vaccine for protection against Lyme borreliosis. PLoS One (2014) 0.80
A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. PLoS Pathog (2014) 0.80
The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes Infect (2013) 0.80
Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease. Curr Opin Microbiol (2015) 0.80
Two regulatory elements required for enhancing ospA expression in Borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection. Microbiology (2010) 0.80
Vaccination against Lyme disease: past, present, and future. Front Cell Infect Microbiol (2013) 0.79
Immunization with a Borrelia burgdorferi BB0172-derived peptide protects mice against lyme disease. PLoS One (2014) 0.78
A chitin deacetylase-like protein is a predominant constituent of tick peritrophic membrane that influences the persistence of Lyme disease pathogens within the vector. PLoS One (2013) 0.78
An inverted repeat in the ospC operator is required for induction in Borrelia burgdorferi. PLoS One (2013) 0.78
Close to home: a history of Yale and Lyme disease. Yale J Biol Med (2011) 0.78
Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut. J Mol Med (Berl) (2015) 0.78
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What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete. Yale J Biol Med (2014) 0.77
Functional insights into recombinant TROSPA protein from Ixodes ricinus. PLoS One (2013) 0.77
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol (2005) 7.55
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage (2008) 6.58
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity (2006) 6.17
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. Neuroimage (2007) 5.23
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic (2003) 4.61
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest (2004) 4.54
Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol (2007) 4.37
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
The pulvinar regulates information transmission between cortical areas based on attention demands. Science (2012) 4.14
Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol (2004) 3.82
Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe. Cell (2007) 3.81
Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe (2009) 3.79
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity (2011) 3.75
Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage (2009) 3.74
Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science (2002) 3.68
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity (2012) 3.43
Gradient-index meta-surfaces as a bridge linking propagating waves and surface waves. Nat Mater (2012) 3.42
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity (2006) 3.38
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol (2009) 3.25
Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn Reson Med (2007) 3.23
Activation of lysosomal function during dendritic cell maturation. Science (2003) 3.22
Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02
A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in suppressor of npr1-1, constitutive 1. Plant Cell (2003) 3.00
Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage (2008) 2.86
Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol (2005) 2.83
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space. Cell (2006) 2.79
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Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J Cell Biol (2004) 2.78
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol (2008) 2.71
The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development. Proc Natl Acad Sci U S A (2004) 2.71
On the origin of new genes in Drosophila. Genome Res (2008) 2.69
Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J Exp Med (2004) 2.67
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis. J Cell Biol (2008) 2.66
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase. Antimicrob Agents Chemother (2003) 2.66
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab (2007) 2.64
Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature (2006) 2.64
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Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63
Host feeding patterns of Culex mosquitoes and West Nile virus transmission, northeastern United States. Emerg Infect Dis (2006) 2.58
Outsourcing CO2 within China. Proc Natl Acad Sci U S A (2013) 2.51
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat Cell Biol (2003) 2.50
C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell (2010) 2.50
Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med (2002) 2.49
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Age-dependent dysregulation of innate immunity. Nat Rev Immunol (2013) 2.44
Multi-contrast human neonatal brain atlas: application to normal neonate development analysis. Neuroimage (2011) 2.41
The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J Cell Biol (2003) 2.39
Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell (2005) 2.35
Knockout analysis of Arabidopsis transcription factors TGA2, TGA5, and TGA6 reveals their redundant and essential roles in systemic acquired resistance. Plant Cell (2003) 2.35
Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell (2002) 2.30
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Contour-based object tracking with occlusion handling in video acquired using mobile cameras. IEEE Trans Pattern Anal Mach Intell (2004) 2.22
Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. Neuroimage (2010) 2.21
Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol (2006) 2.20
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe (2007) 2.17
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci U S A (2008) 2.17
Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. Vector Borne Zoonotic Dis (2004) 2.15
A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol (2003) 2.15
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. EMBO J (2003) 2.15
The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12
Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol (2007) 2.12
The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo. Am J Hematol (2009) 2.12
Human Borrelia miyamotoi infection in the United States. N Engl J Med (2013) 2.11
Comparison of intravitreal triamcinolone acetonide versus intravitreal bevacizumab as the primary treatment of clinically significant macular edema. Retina (2015) 2.08
Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity (2012) 2.08
A putative nucleoporin 96 Is required for both basal defense and constitutive resistance responses mediated by suppressor of npr1-1,constitutive 1. Plant Cell (2005) 2.06
Silent substitutions predictably alter translation elongation rates and protein folding efficiencies. J Mol Biol (2012) 2.04
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol (2003) 2.03
Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. Neuroimage (2009) 2.01
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00