Published in Mol Microbiol on July 23, 2007
Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol (2012) 3.52
Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol (2008) 2.23
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest (2009) 1.78
Lipoproteins of bacterial pathogens. Infect Immun (2010) 1.73
Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi. Infect Immun (2008) 1.63
The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. PLoS Pathog (2015) 1.54
In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice. PLoS Pathog (2013) 1.49
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol Microbiol (2009) 1.45
Characterization of the RelBbu regulon in borrelia burgdorferi reveals modulation of glycerol metabolism by (p)ppGpp. PLoS One (2015) 1.45
BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol (2009) 1.42
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Mol Microbiol (2009) 1.37
Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am (2008) 1.35
Role of RpoS in virulence of pathogens. Infect Immun (2009) 1.35
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog (2010) 1.29
The unique paradigm of spirochete motility and chemotaxis. Annu Rev Microbiol (2012) 1.26
Borrelia burgdorferi uniquely regulates its motility genes and has an intricate flagellar hook-basal body structure. J Bacteriol (2008) 1.23
BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog (2011) 1.22
Borrelia burgdorferi RevA antigen binds host fibronectin. Infect Immun (2009) 1.21
Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission. PLoS Pathog (2012) 1.20
Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. J Bacteriol (2009) 1.18
BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle. J Infect Dis (2009) 1.18
Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease. Infect Immun (2007) 1.17
The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol (2012) 1.16
BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts. J Infect Dis (2010) 1.16
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14
Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol (2010) 1.12
Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice. Mol Microbiol (2009) 1.12
Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector. Future Microbiol (2013) 1.12
Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks. PLoS Pathog (2011) 1.08
The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission. Proc Natl Acad Sci U S A (2010) 1.07
CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi. Infect Immun (2010) 1.07
The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun (2011) 1.07
Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog (2011) 1.06
Characterization of a conditional bosR mutant in Borrelia burgdorferi. Infect Immun (2009) 1.06
Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol (2009) 1.06
Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi. Infect Immun (2010) 1.05
Characterization of multiprotein complexes of the Borrelia burgdorferi outer membrane vesicles. J Proteome Res (2011) 1.04
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni. PLoS Pathog (2014) 1.03
Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2010) 1.03
Carbon storage regulator A (CsrA(Bb)) is a repressor of Borrelia burgdorferi flagellin protein FlaB. Mol Microbiol (2011) 1.02
DhhP, a cyclic di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence. Infect Immun (2014) 1.02
Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi. FEMS Immunol Med Microbiol (2009) 1.01
Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Mol Microbiol (2010) 1.01
Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation. Mol Microbiol (2014) 1.00
Who is the BosR around here anyway? Mol Microbiol (2009) 1.00
Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi. Mol Microbiol (2013) 1.00
Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol (2012) 0.97
The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks. Mol Microbiol (2012) 0.97
Changes in bacterial growth rate govern expression of the Borrelia burgdorferi OspC and Erp infection-associated surface proteins. J Bacteriol (2012) 0.95
Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of Borrelia burgdorferi. Infect Immun (2009) 0.94
Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect Immun (2008) 0.93
Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection are conserved among diverse Borrelia spp. Infect Immun (2008) 0.93
Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol Microbiol (2008) 0.93
Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation. PLoS One (2011) 0.92
Verification and dissection of the ospC operator by using flaB promoter as a reporter in Borrelia burgdorferi. Microb Pathog (2008) 0.91
Reciprocal expression of ospA and ospC in single cells of Borrelia burgdorferi. J Bacteriol (2008) 0.91
Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect Immun (2013) 0.91
EbfC (YbaB) is a new type of bacterial nucleoid-associated protein and a global regulator of gene expression in the Lyme disease spirochete. J Bacteriol (2012) 0.91
HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete. PLoS One (2011) 0.90
Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2009) 0.90
Effect of Borrelia burgdorferi OspC at the site of inoculation in mouse skin. Infect Immun (2010) 0.89
Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi. J Bacteriol (2007) 0.89
BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins. J Bacteriol (2011) 0.88
Manganese and zinc regulate virulence determinants in Borrelia burgdorferi. Infect Immun (2013) 0.88
The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi. BMC Microbiol (2010) 0.88
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi. Front Cell Infect Microbiol (2014) 0.88
Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi. J Bacteriol (2012) 0.87
Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi. Infect Immun (2011) 0.86
The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol (2011) 0.86
Analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen Treponema denticola. J Bacteriol (2008) 0.86
BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle. Infect Immun (2010) 0.86
Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease. Infect Immun (2008) 0.86
Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission. Infect Immun (2015) 0.86
Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS. PLoS One (2014) 0.86
HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. PLoS Pathog (2013) 0.86
Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi. Infect Immun (2013) 0.85
BorreliaBase: a phylogeny-centered browser of Borrelia genomes. BMC Bioinformatics (2014) 0.85
Chitobiose utilization in Borrelia burgdorferi is dually regulated by RpoD and RpoS. BMC Microbiol (2009) 0.85
RpoS regulates essential virulence factors remaining to be identified in Borrelia burgdorferi. PLoS One (2012) 0.85
Regulation of the virulence determinant OspC by bbd18 on linear plasmid lp17 of Borrelia burgdorferi. J Bacteriol (2011) 0.85
Interaction of Borrelia burgdorferi Hbb with the p66 promoter. Nucleic Acids Res (2009) 0.85
Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection. Mol Microbiol (2013) 0.85
Contributions of environmental signals and conserved residues to the functions of carbon storage regulator A of Borrelia burgdorferi. Infect Immun (2013) 0.84
Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi. J Bacteriol (2010) 0.83
CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. Infect Immun (2014) 0.81
Metal-dependent gene regulation in the causative agent of Lyme disease. Front Cell Infect Microbiol (2013) 0.81
Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi. PLoS One (2015) 0.81
Treponema pallidum, the stealth pathogen, changes, but how? Mol Microbiol (2009) 0.81
Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi. Infect Immun (2015) 0.81
Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi. Mol Microbiol (2016) 0.81
Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi. PLoS One (2014) 0.81
Two regulatory elements required for enhancing ospA expression in Borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection. Microbiology (2010) 0.80
The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes Infect (2013) 0.80
Increasing RpoS expression causes cell death in Borrelia burgdorferi. PLoS One (2013) 0.80
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. Appl Environ Microbiol (2013) 0.80
The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis. Mol Microbiol (2015) 0.80
Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmission. Infect Immun (2013) 0.80
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog (2016) 0.80
Altered murine tissue colonization by Borrelia burgdorferi following targeted deletion of linear plasmid 17-carried genes. Infect Immun (2012) 0.80
Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion. Front Immunol (2017) 0.80
Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Anal Biochem (1981) 29.21
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature (1997) 19.08
MEME: discovering and analyzing DNA and protein sequence motifs. Nucleic Acids Res (2006) 15.32
Physiological and genetic responses of bacteria to osmotic stress. Microbiol Rev (1989) 10.77
Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A (1995) 9.93
A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol (2000) 7.60
PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics (2004) 7.15
Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci (2003) 6.85
Signal transduction and regulatory mechanisms involved in control of the sigma(S) (RpoS) subunit of RNA polymerase. Microbiol Mol Biol Rev (2002) 5.60
Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity. J Bacteriol (2005) 4.86
Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol (2000) 4.71
Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals. Proc Natl Acad Sci U S A (2004) 3.84
DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci U S A (2002) 3.82
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci U S A (2001) 3.65
Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun (2002) 3.65
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest (1998) 3.41
Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. J Bacteriol (1993) 3.35
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proc Natl Acad Sci U S A (2001) 3.28
Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell (1997) 3.25
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J Exp Med (1996) 3.23
Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun (2003) 3.19
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02
Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi. Mol Microbiol (2000) 3.00
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92
Effects of environmental pH on membrane proteins in Borrelia burgdorferi. Infect Immun (1999) 2.91
Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect Immun (2003) 2.79
Molecular analysis of rugosity in a Vibrio cholerae O1 El Tor phase variant. Mol Microbiol (2004) 2.66
The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing. Mol Microbiol (2004) 2.63
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell (2004) 2.62
Negative regulation by RpoS: a case of sigma factor competition. Mol Microbiol (1998) 2.57
Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest (2000) 2.56
Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection. Infect Immun (2006) 2.54
UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition. Mol Microbiol (2000) 2.52
Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med (2002) 2.49
Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol (2004) 2.47
Borrelia burgdorferi sigma54 is required for mammalian infection and vector transmission but not for tick colonization. Proc Natl Acad Sci U S A (2005) 2.41
Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array. Infect Immun (2004) 2.35
The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2003) 2.31
Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete. Mol Microbiol (2002) 2.28
Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23
SigmaS-dependent gene expression at the onset of stationary phase in Escherichia coli: function of sigmaS-dependent genes and identification of their promoter sequences. J Bacteriol (2004) 2.17
Alternative sigma factors and their roles in bacterial virulence. Microbiol Mol Biol Rev (2005) 2.15
Microarray analysis of RpoS-mediated gene expression in Escherichia coli K-12. Mol Genet Genomics (2004) 2.04
Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis. Microbes Infect (2001) 2.02
Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology (1998) 2.01
Bacterial shape. Mol Microbiol (2003) 2.00
Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00
Lipoprotein computational prediction in spirochaetal genomes. Microbiology (2006) 1.98
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi. Mol Microbiol (2006) 1.93
Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect Immun (2003) 1.82
The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect Immun (1999) 1.79
Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi. Mol Microbiol (2007) 1.77
Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface. Infect Immun (2002) 1.76
Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun (2001) 1.73
The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol Rev (2006) 1.73
Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids. Infect Immun (2000) 1.71
Promoter selectivity of Escherichia coli RNA polymerase E sigma 70 and E sigma 38 holoenzymes. Effect of DNA supercoiling. J Biol Chem (1996) 1.69
The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi. Mol Microbiol (2007) 1.66
The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infect Immun (1997) 1.65
Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. J Immunol (2001) 1.58
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57
What makes an Escherichia coli promoter sigma(S) dependent? Role of the -13/-14 nucleotide promoter positions and region 2.5 of sigma(S). Mol Microbiol (2001) 1.57
Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host. Infect Immun (2006) 1.55
Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity. Infect Immun (2000) 1.53
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52
Identification of conserved, RpoS-dependent stationary-phase genes of Escherichia coli. J Bacteriol (1998) 1.49
The molecular basis of selective promoter activation by the sigmaS subunit of RNA polymerase. Mol Microbiol (2007) 1.46
Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol (2005) 1.44
Recovery of Lyme disease spirochetes from patients. Yale J Biol Med (1985) 1.42
Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin. Infect Immun (2004) 1.42
Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes Infect (2003) 1.41
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40
OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infect Immun (1997) 1.38
Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J Biol Chem (2000) 1.36
Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins. J Immunol (1999) 1.36
Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes. J Bacteriol (2004) 1.35
Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties. J Bacteriol (2006) 1.34
Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). J Bacteriol (2006) 1.34
Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi. Mol Microbiol (2003) 1.33
Linear and circular plasmid content in Borrelia burgdorferi clinical isolates. Infect Immun (2003) 1.33
Identification of an ospC operator critical for immune evasion of Borrelia burgdorferi. Mol Microbiol (2007) 1.33
Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis. J Bacteriol (1996) 1.31
Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi. J Bacteriol (1996) 1.27
Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response. Mol Microbiol (2006) 1.26
Artificial regulation of ospC expression in Borrelia burgdorferi. Mol Microbiol (2007) 1.26
Molecular characterization of Borrelia burgdorferi erp promoter/operator elements. J Bacteriol (2004) 1.26
Bacteriophages of spirochetes. J Mol Microbiol Biotechnol (2000) 1.25
Demonstration of the genetic stability and temporal expression of select members of the lyme disease spirochete OspF protein family during infection in mice. Infect Immun (2001) 1.25
Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding. Mol Microbiol (2003) 1.24
Identification of Borrelia burgdorferi outer surface proteins. Infect Immun (2006) 1.23
The extended promoters for two outer membrane lipoprotein genes of Borrelia spp. uniquely include a T-rich region. Mol Microbiol (1999) 1.22
Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi. J Bacteriol (2002) 1.20
Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiol Rev (2003) 1.19
Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants. J Bacteriol (1983) 1.18
Pentose phosphates in nucleoside interconversion and catabolism. FEBS J (2006) 1.17
Role of the spacer between the -35 and -10 regions in sigmas promoter selectivity in Escherichia coli. Mol Microbiol (2006) 1.15
Plasmid requirements for infection of ticks by Borrelia burgdorferi. Vector Borne Zoonotic Dis (2005) 1.15
Effect of rpoS gene knockout on the metabolism of Escherichia coli during exponential growth phase and early stationary phase based on gene expressions, enzyme activities and intracellular metabolite concentrations. Biotechnol Bioeng (2006) 1.08
Diagnosis of lyme borreliosis. Clin Microbiol Rev (2005) 4.48
Differentiation of reinfection from relapse in recurrent Lyme disease. N Engl J Med (2012) 3.79
Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun (2002) 3.65
Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun (2003) 3.19
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 2.67
Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete. Mol Microbiol (2002) 2.28
Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease. J Infect Dis (2008) 2.26
aadA confers streptomycin resistance in Borrelia burgdorferi. J Bacteriol (2003) 2.22
Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain. J Infect Dis (2002) 1.97
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94
The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans. Am J Trop Med Hyg (2008) 1.82
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest (2009) 1.78
An outbreak of mycobacterial furunculosis associated with footbaths at a nail salon. N Engl J Med (2002) 1.69
Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle. Infect Immun (2004) 1.55
Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans. J Immunol (2003) 1.53
Antibiotic treatment of animals infected with Borrelia burgdorferi. Clin Microbiol Rev (2009) 1.51
Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis (2002) 1.49
Electrical twitch-obtaining intramuscular stimulation in lower back pain: a pilot study. Am J Phys Med Rehabil (2004) 1.49
Increasing health burden of human babesiosis in endemic sites. Am J Trop Med Hyg (2003) 1.47
Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. PLoS Pathog (2009) 1.47
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol Microbiol (2009) 1.45
Single-dose prophylaxis against Lyme disease. Lancet Infect Dis (2007) 1.45
The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Mol Microbiol (2006) 1.44
PCR-based identification of bacteria associated with endodontic infections. J Clin Microbiol (2002) 1.42
Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production. Infect Immun (2007) 1.42
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40
Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol (2002) 1.40
Interaction and transmission of two Borrelia burgdorferi sensu stricto strains in a tick-rodent maintenance system. Appl Environ Microbiol (2004) 1.38
Fitness variation of Borrelia burgdorferi sensu stricto strains in mice. Appl Environ Microbiol (2007) 1.36
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta. Proc Natl Acad Sci U S A (2011) 1.36
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 1.35
Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes. J Bacteriol (2004) 1.35
Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties. J Bacteriol (2006) 1.34
Linear and circular plasmid content in Borrelia burgdorferi clinical isolates. Infect Immun (2003) 1.33
Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes. Infect Immun (2007) 1.31
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog (2010) 1.29
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. J Exp Med (2007) 1.29
Artificial regulation of ospC expression in Borrelia burgdorferi. Mol Microbiol (2007) 1.26
Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proc Natl Acad Sci U S A (2003) 1.26
Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding. Mol Microbiol (2003) 1.24
Improving the yield of blood cultures from patients with early Lyme disease. J Clin Microbiol (2011) 1.22
Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis. J Immunol (2009) 1.22
Genetics of Borrelia burgdorferi. Annu Rev Genet (2012) 1.21
The crystal structure of Zn(II)-free Treponema pallidum TroA, a periplasmic metal-binding protein, reveals a closed conformation. J Bacteriol (2002) 1.21
The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue. Proc Natl Acad Sci U S A (2012) 1.20
Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission. PLoS Pathog (2012) 1.20
Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. J Bacteriol (2009) 1.18
CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A (2012) 1.18
Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells. J Immunol (2009) 1.18
Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infect Immun (2010) 1.17
Borrelia burgdorferi gene expression profiling with membrane-based arrays. Methods Enzymol (2002) 1.16
The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase. J Biol Chem (2003) 1.16
Borrelia burgdorferi sensu stricto is clonal in patients with early Lyme borreliosis. Appl Environ Microbiol (2008) 1.16
The immune response to infection with Treponema pallidum, the stealth pathogen. Microbes Infect (2002) 1.16
The general transition metal (Tro) and Zn2+ (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles. Mol Microbiol (2007) 1.14
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14
Impaired host defense to infection and Toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H/HeJ mice. FEMS Microbiol Lett (2004) 1.13
Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease. J Immunol (2005) 1.11
Comparative transcriptional profiling of Borrelia burgdorferi clinical isolates differing in capacities for hematogenous dissemination. Infect Immun (2005) 1.11
Comparison of five diagnostic modalities for direct detection of Borrelia burgdorferi in patients with early Lyme disease. Diagn Microbiol Infect Dis (2012) 1.10
Microbiologic evaluation of patients from Missouri with erythema migrans. Clin Infect Dis (2005) 1.10
Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates. Infect Immun (2004) 1.08
Multilocus sequence typing of Borrelia burgdorferi suggests existence of lineages with differential pathogenic properties in humans. PLoS One (2013) 1.07
The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun (2011) 1.07
TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein. Mol Microbiol (2011) 1.06
Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog (2011) 1.06
CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance. PLoS Pathog (2009) 1.06
Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments. PLoS Negl Trop Dis (2012) 1.05
Serodiagnosis of syphilis in the recombinant era: reversal of fortune. J Infect Dis (2011) 1.05
Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the -10 region. Mol Microbiol (2006) 1.03
Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease. Clin Infect Dis (2008) 1.03
Real-time PCR for simultaneous detection and quantification of Borrelia burgdorferi in field-collected Ixodes scapularis ticks from the Northeastern United States. Appl Environ Microbiol (2003) 1.02
Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Mol Microbiol (2010) 1.01
Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi. FEMS Immunol Med Microbiol (2009) 1.01
Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation. Mol Microbiol (2014) 1.00