PubRank

David C Rubinsztein

Author PubWeight™ 329.18‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2007 20.92
2 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
3 Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009 15.15
4 Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004 14.31
5 Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011 9.23
6 TFEB links autophagy to lysosomal biogenesis. Science 2011 8.87
7 Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003 6.84
8 Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002 6.56
9 Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol 2010 6.41
10 Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010 6.35
11 Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 2007 5.78
12 Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2006 5.39
13 Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 2005 5.21
14 Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 2009 5.18
15 Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol 2011 4.96
16 In search of an "autophagomometer". Autophagy 2009 4.31
17 Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 2008 4.19
18 α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 2010 3.67
19 Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 2008 3.47
20 Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet 2005 3.45
21 Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet 2005 3.39
22 A block of autophagy in lysosomal storage disorders. Hum Mol Genet 2007 3.28
23 The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 2008 3.18
24 Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol 2006 3.02
25 A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet 2002 2.98
26 Transcriptional abnormalities in Huntington disease. Trends Genet 2003 2.91
27 Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett 2009 2.58
28 Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet 2006 2.57
29 Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One 2010 2.57
30 Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci 2008 2.55
31 Huntington's disease: from pathology and genetics to potential therapies. Biochem J 2008 2.41
32 Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet 2002 2.41
33 Autophagosome precursor maturation requires homotypic fusion. Cell 2011 2.39
34 Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol 2011 2.38
35 Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 2011 2.36
36 Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet 2010 2.22
37 Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci 2006 2.19
38 The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell 2012 2.14
39 Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 2013 2.07
40 A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet 2007 2.03
41 A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy 2011 2.02
42 A comprehensive glossary of autophagy-related molecules and processes. Autophagy 2010 2.00
43 Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol 2011 1.97
44 Huntington's disease: degradation of mutant huntingtin by autophagy. FEBS J 2008 1.89
45 Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest 2011 1.89
46 Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease. J Nucl Med 2006 1.83
47 Cytoprotective roles for autophagy. Curr Opin Cell Biol 2010 1.81
48 The Hedgehog signalling pathway regulates autophagy. Nat Commun 2012 1.80
49 Mammalian macroautophagy at a glance. J Cell Sci 2009 1.78
50 DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet 2006 1.73
51 Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J Biol Chem 2002 1.70
52 Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain 2009 1.66
53 Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell 2012 1.55
54 Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci 2004 1.54
55 Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem 2010 1.50
56 Lysosomal storage diseases as disorders of autophagy. Autophagy 2007 1.46
57 Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function. Proc Natl Acad Sci U S A 2007 1.45
58 Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol 2010 1.45
59 Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. Hum Mol Genet 2005 1.44
60 Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy 2006 1.42
61 Small molecule enhancers of autophagy for neurodegenerative diseases. Mol Biosyst 2008 1.39
62 Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet 2010 1.38
63 Autophagy in neurodegeneration and development. Biochim Biophys Acta 2008 1.38
64 Protein misfolding disorders and macroautophagy. Curr Opin Cell Biol 2010 1.36
65 Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy 2009 1.36
66 Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet 2005 1.32
67 Can autophagy protect against neurodegeneration caused by aggregate-prone proteins? Neuroreport 2004 1.31
68 Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol 2013 1.31
69 Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet 2010 1.30
70 Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat Med 2005 1.30
71 Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. Methods Enzymol 2009 1.28
72 Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int J Biochem Cell Biol 2004 1.28
73 Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis. J Biol Chem 2003 1.27
74 Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med 2009 1.26
75 Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Brain 2003 1.26
76 Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. J Cell Biol 2005 1.24
77 Autophagy and neurodegeneration. J Clin Invest 2015 1.24
78 Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex. J Cell Sci 2011 1.23
79 Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain 2006 1.20
80 Regulation of autophagy by lysosomal positioning. Autophagy 2011 1.19
81 Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 2003 1.19
82 Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem 2006 1.18
83 Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy 2007 1.17
84 Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol 2012 1.16
85 Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Hum Mol Genet 2010 1.15
86 Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. J Am Geriatr Soc 2006 1.15
87 Modulation of polyglutamine-induced cell death by genes identified by expression profiling. Hum Mol Genet 2002 1.12
88 Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology 2006 1.12
89 Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res 2006 1.12
90 Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell 2010 1.12
91 A novel link between autophagy and the ubiquitin-proteasome system. Autophagy 2009 1.11
92 Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci 2008 1.10
93 Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres. Hum Mol Genet 2010 1.10
94 Autophagy and misfolded proteins in neurodegeneration. Exp Neurol 2010 1.10
95 Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med 2006 1.08
96 Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species. J Cell Sci 2014 1.06
97 Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J Biol Chem 2002 1.05
98 The role of membrane-trafficking small GTPases in the regulation of autophagy. J Cell Sci 2013 1.04
99 Connections between SNAREs and autophagy. Trends Biochem Sci 2013 1.04
100 Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Hum Mol Genet 2007 1.03
101 Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation. FEBS Lett 2013 1.02
102 The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis 2012 1.02
103 Autophagy and polyglutamine diseases. Prog Neurobiol 2011 1.02
104 Measurement of autophagic activity in mammalian cells. Curr Protoc Cell Biol 2012 1.01
105 The Parkinson disease protein α-synuclein inhibits autophagy. Autophagy 2011 1.00
106 p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity. Hum Mol Genet 2007 1.00
107 Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation. Hum Mol Genet 2008 0.99
108 Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway. Hum Mol Genet 2005 0.98
109 Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. Hum Mol Genet 2005 0.97
110 Plasma membrane helps autophagosomes grow. Autophagy 2010 0.97
111 Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. J Neurosci 2009 0.96
112 BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy 2012 0.95
113 Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet 2010 0.94
114 The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias. BMC Biochem 2007 0.93
115 Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci 2005 0.93
116 Spinocerebellar ataxias caused by polyglutamine expansions: a review of therapeutic strategies. Cerebellum 2008 0.92
117 Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet B Neuropsychiatr Genet 2005 0.92
118 No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 2011 0.91
119 Protective roles for induction of autophagy in multiple proteinopathies. Autophagy 2006 0.91
120 Therapeutic induction of autophagy to modulate neurodegenerative disease progression. Acta Pharmacol Sin 2013 0.91
121 Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder. Int J Biochem Cell Biol 2006 0.91
122 Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users. Am J Psychiatry 2005 0.91
123 Clearance of mutant aggregate-prone proteins by autophagy. Methods Mol Biol 2008 0.89
124 Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy. Sci Transl Med 2010 0.89
125 Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiol Aging 2010 0.88
126 Broadening the therapeutic scope for rapamycin treatment. Autophagy 2010 0.88
127 Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging 2012 0.88
128 Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci 2005 0.88
129 Huntingtin promotes cell survival by preventing Pak2 cleavage. J Cell Sci 2009 0.87
130 1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol (Gln) induces cell death with more autophagosomes which is autophagy-independent. Autophagy 2009 0.87
131 IGF-1 receptor antagonism inhibits autophagy. Hum Mol Genet 2013 0.87
132 Autophagic activity in neuronal cell death. Neurosci Bull 2015 0.86
133 α-Synuclein levels modulate Huntington's disease in mice. Hum Mol Genet 2011 0.86
134 Autophagy and mammalian development. Biochem Soc Trans 2013 0.85
135 Myc inhibition impairs autophagosome formation. Hum Mol Genet 2013 0.85
136 The plasma membrane as a control center for autophagy. Autophagy 2012 0.85
137 No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease. Ann Neurol 2002 0.84
138 Absence of relationship between MTTP haplotypes and longevity. J Gerontol A Biol Sci Med Sci 2007 0.83
139 Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet 2011 0.82
140 Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neurosci Lett 2004 0.82
141 alpha Pix enhances mutant huntingtin aggregation. J Neurol Sci 2009 0.82
142 Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease. Neurosci Lett 2005 0.81
143 α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology. Autophagy 2012 0.81
144 NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases. BMC Med Genomics 2013 0.81
145 Zebrafish as a model to understand autophagy and its role in neurological disease. Biochim Biophys Acta 2011 0.80
146 Rapamycin induces autophagic flux in neurons. Proc Natl Acad Sci U S A 2010 0.80
147 Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections. Autophagy 2015 0.79
148 Impaired autophagy in Lafora disease. Autophagy 2010 0.79
149 LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells. Methods Mol Biol 2016 0.77
150 The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington's disease. Neurosci Lett 2002 0.76
151 Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging 2008 0.75