LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 528889)

Published in Genes Dev on November 15, 2004

Authors

Juan Galceran1, Claudio Sustmann, Shu-Chi Hsu, Stephanie Folberth, Rudolf Grosschedl

Author Affiliations

1: Gene Center and Institute of Biochemistry, University of Munich, 81377 Munich, Germany.

Articles citing this

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature (2010) 3.54

Notch tumor suppressor function. Oncogene (2008) 2.26

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone. Proc Natl Acad Sci U S A (2015) 2.25

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17

Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell (2006) 2.06

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis. Blood (2010) 1.80

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development (2005) 1.76

WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74

Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol (2005) 1.66

Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development (2008) 1.42

Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes Dev (2005) 1.29

Hes1 is required for pituitary growth and melanotrope specification. Dev Biol (2006) 1.20

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep (2007) 1.17

Aging of signal transduction pathways, and pathology. Exp Cell Res (2008) 1.16

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun (2011) 1.07

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Proc Natl Acad Sci U S A (2006) 1.07

Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol (2012) 1.06

Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03

A proposed mechanism for the interaction of the segmentation clock and the determination front in somitogenesis. PLoS One (2008) 1.02

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation. Matrix Biol (2008) 1.02

The segmentation clock mechanism moves up a notch. Trends Cell Biol (2010) 1.01

The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. PLoS One (2011) 0.97

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis. Nat Commun (2013) 0.96

Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One (2009) 0.92

Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts. J Mol Histol (2007) 0.92

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies. Lab Invest (2015) 0.91

The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites. BMC Dev Biol (2010) 0.90

Notch and Wnt signaling, physiological stimuli and postnatal myogenesis. Int J Biol Sci (2010) 0.90

Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via beta-catenin and Dlk1. J Biol Chem (2009) 0.89

The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways. Exp Cell Res (2011) 0.88

Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines. J Cancer Res Clin Oncol (2010) 0.87

The mouse notches up another success: understanding the causes of human vertebral malformation. Mamm Genome (2011) 0.86

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM. Development (2014) 0.85

Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol (2008) 0.85

Nanosecond pulsed electric field inhibits cancer growth followed by alteration in expressions of NF-κB and Wnt/β-catenin signaling molecules. PLoS One (2013) 0.85

Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development (2014) 0.84

Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS One (2009) 0.83

Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. Theor Biol Med Model (2013) 0.83

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A (2015) 0.82

Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine. PLoS One (2013) 0.81

From dynamic expression patterns to boundary formation in the presomitic mesoderm. PLoS Comput Biol (2012) 0.81

Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. PLoS One (2013) 0.81

Chromatin-based mechanisms of renal epithelial differentiation. J Am Soc Nephrol (2011) 0.79

Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model. PLoS One (2014) 0.79

Mini-review: Does Notch promote or suppress cancer? New findings and old controversies. Am J Clin Exp Urol (2015) 0.79

Overexpression of lymphoid enhancer-binding factor 1 (LEF1) in solid-pseudopapillary neoplasms of the pancreas. Mod Pathol (2014) 0.78

Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis (2015) 0.77

Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Eng Part B Rev (2015) 0.77

Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. J Neurosci (2016) 0.77

Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex. Mol Cell Biol (2016) 0.76

Practical lessons from theoretical models about the somitogenesis. Gene Regul Syst Bio (2007) 0.76

Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock. Biomed Res Int (2014) 0.76

Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep (2016) 0.75

Targeting the Notch signaling pathway in cancer therapeutics. Thorac Cancer (2014) 0.75

Progress and perspective of TBX6 gene in congenital vertebral malformations. Oncotarget (2016) 0.75

Articles cited by this

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Notch1 is required for the coordinate segmentation of somites. Development (1995) 4.33

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol (1998) 3.79

An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature (1995) 3.78

Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77

Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development (1989) 3.61

Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A (1996) 3.57

Maintenance of somite borders in mice requires the Delta homologue DII1. Nature (1997) 3.44

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature (2000) 3.35

Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci U S A (2000) 2.97

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev (1999) 2.94

The segmentation clock: converting embryonic time into spatial pattern. Science (2003) 2.56

Defects in somite formation in lunatic fringe-deficient mice. Nature (1998) 2.37

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. Development (1993) 2.22

lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09

Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development (2000) 2.01

Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev (1997) 1.97

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94

TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol (2002) 1.93

The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet (2001) 1.88

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev (2002) 1.88

WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74

Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol (1999) 1.73

Vertebrate somitogenesis. Annu Rev Cell Dev Biol (2001) 1.67

A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech Dev (1996) 1.44

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev (2001) 1.41

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol (1998) 1.41

Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A (2001) 1.35

Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development (2003) 1.32

Distinct regulatory elements direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice. Mech Dev (2000) 1.23

Defective somite patterning in mouse embryos with reduced levels of Tbx6. Development (2003) 1.14

Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development (2004) 1.05

Articles by these authors

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell (2006) 4.01

Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron (2008) 3.62

Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes Dev (2007) 2.95

Assembling a gene regulatory network for specification of the B cell fate. Dev Cell (2004) 2.46

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell (2008) 2.25

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol (2008) 2.19

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Genes Dev (2003) 2.17

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol (2012) 2.15

Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity (2010) 2.08

The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell (2006) 1.90

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev (2002) 1.88

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development (2003) 1.88

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci U S A (2011) 1.85

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol (2006) 1.81

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development (2004) 1.74

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development (2002) 1.70

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67

Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol (2006) 1.55

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med (2006) 1.52

Satb1 and Satb2 are dispensable for X chromosome inactivation in mice. Dev Cell (2012) 1.51

Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A (2007) 1.50

EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell (2005) 1.40

Transcription control of early B cell differentiation. Curr Opin Immunol (2010) 1.38

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J (2004) 1.37

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies. MAbs (2012) 1.29

A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A (2012) 1.26

Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nat Immunol (2013) 1.21

The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development (2002) 1.18

LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol (2005) 1.17

Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. Mol Cell Biol (2008) 1.17

Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev (2012) 1.13

PIASy-deficient mice display modest defects in IFN and Wnt signaling. J Immunol (2004) 1.10

Memories of lost enhancers. Genes Dev (2010) 1.05

The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. Immunol Rev (2014) 1.02

Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner. Cell Stem Cell (2010) 1.01

Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Eng Part A (2011) 0.99

Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins. Genes Dev (2010) 0.98

Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol (2003) 0.97

PIAS proteins as repressors of Oct4 function. J Mol Biol (2007) 0.93

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity (2010) 0.92

Role of transcription factors in commitment and differentiation of early B lymphoid cells. Semin Immunol (2006) 0.91

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med (2012) 0.91

Sensory map transfer to the neocortex relies on pretarget ordering of thalamic axons. Curr Biol (2013) 0.86

SALL4 is directly activated by TCF/LEF in the canonical Wnt signaling pathway. Biochem Biophys Res Commun (2006) 0.86

Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes. Biochemistry (2003) 0.85

Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing. Protein Eng Des Sel (2012) 0.83

Genetic interaction between Lef1 and Alx4 is required for early embryonic development. Int J Dev Biol (2006) 0.79

Blurring cis and trans in gene regulation. Cell (2006) 0.78

FOXtrot and RAGtime in B cells. Nat Immunol (2006) 0.78

A phase 1 open-label, sequential dose-escalation study investigating the safety, tolerability, and pharmacokinetics of intravenous TLC388 administered to patients with advanced solid tumors. Invest New Drugs (2013) 0.77

Multitasking of interferon regulatory factor-4 in early B cells. Immunity (2008) 0.75

The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Lett (2013) 0.75

A comprehensive Proteomic Investigation of Ebf1 Heterozygosity in pro-B lymphocytes utilizing Data Independent Acquisition (DIA). J Proteome Res (2017) 0.75