Published in Structure on December 01, 2004
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family. J Gen Physiol (2005) 1.64
EGFR-mutated lung cancer: a paradigm of molecular oncology. Oncotarget (2010) 1.53
EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism. Oncogene (2010) 1.30
Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy. FEBS Lett (2010) 1.30
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity. Mol Cell Biol (2006) 1.18
Protein interface classification by evolutionary analysis. BMC Bioinformatics (2012) 1.11
The ErbB kinase domain: structural perspectives into kinase activation and inhibition. Exp Cell Res (2008) 1.08
Physical-chemical principles underlying RTK activation, and their implications for human disease. Biochim Biophys Acta (2011) 1.06
HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks. Breast Cancer Res (2007) 1.02
Kinase-mediated quasi-dimers of EGFR. FASEB J (2010) 1.01
Conformational changes accompany phosphorylation of the epidermal growth factor receptor C-terminal domain. Protein Sci (2005) 0.93
Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. Hepatology (2012) 0.88
Structure and dynamics of the epidermal growth factor receptor C-terminal phosphorylation domain. Protein Sci (2006) 0.88
Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modeling. Biophys J (2013) 0.87
Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain. Oncogene (2009) 0.82
Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search. Eur Biophys J (2008) 0.79
A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer. J Cancer Res Clin Oncol (2008) 0.79
Co-conserved features associated with cis regulation of ErbB tyrosine kinases. PLoS One (2010) 0.78
Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants. Oncotarget (2015) 0.76
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res (2010) 9.68
ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics (2003) 7.83
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol (2011) 7.33
Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics (2002) 4.54
Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol Biol Evol (2004) 3.62
ConSeq: the identification of functionally and structurally important residues in protein sequences. Bioinformatics (2004) 3.50
High-resolution mapping of protein sequence-function relationships. Nat Methods (2010) 3.47
Comment on "Network motifs: simple building blocks of complex networks" and "Superfamilies of evolved and designed networks". Science (2004) 2.37
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat Biotechnol (2012) 2.14
The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures. Nucleic Acids Res (2008) 2.04
A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86
The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Proteins (2005) 1.72
A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell (2004) 1.54
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51
Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain. J Mol Biol (2006) 1.47
Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. J Mol Biol (2009) 1.43
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction. Proc Natl Acad Sci U S A (2010) 1.34
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. J Biol Chem (2007) 1.32
Detection of functionally important regions in "hypothetical proteins" of known structure. Structure (2008) 1.31
A novel scoring function for predicting the conformations of tightly packed pairs of transmembrane alpha-helices. J Mol Biol (2002) 1.29
Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. Proc Natl Acad Sci U S A (2010) 1.26
Co-evolving residues in membrane proteins. Bioinformatics (2007) 1.25
Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins (2013) 1.20
Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J (2008) 1.18
The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol (2004) 1.18
In silico identification of functional regions in proteins. Bioinformatics (2005) 1.18
Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys J (2004) 1.14
Transmembrane protein structures without X-rays. Trends Biochem Sci (2006) 1.13
Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors. Biochim Biophys Acta (2007) 1.10
Free diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculations. Biophys J (2004) 1.10
QuasiMotiFinder: protein annotation by searching for evolutionarily conserved motif-like patterns. Nucleic Acids Res (2005) 1.09
Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology (2006) 1.08
RosettaDock in CAPRI rounds 6-12. Proteins (2007) 1.08
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Type I chaperonins: not all are created equal. FEBS Lett (2002) 1.05
A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism. Metallomics (2012) 1.05
New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation. J Chem Inf Model (2012) 1.03
Quality assessment of protein model-structures using evolutionary conservation. Bioinformatics (2010) 1.01
An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. J Mol Biol (2004) 1.00
Interactions of hydrophobic peptides with lipid bilayers: Monte Carlo simulations with M2delta. Biophys J (2003) 1.00
An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data. Biophys J (2004) 1.00
iDBPs: a web server for the identification of DNA binding proteins. Bioinformatics (2010) 0.98
Computational design of a protein-based enzyme inhibitor. J Mol Biol (2013) 0.98
Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex. J Mol Biol (2012) 0.98
Emerging themes in the computational design of novel enzymes and protein-protein interfaces. FEBS Lett (2012) 0.98
Intrinsically disordered C-terminal segments of voltage-activated potassium channels: a possible fishing rod-like mechanism for channel binding to scaffold proteins. Bioinformatics (2006) 0.97
MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. Nucleic Acids Res (2010) 0.96
Has the code for protein translocation been broken? Trends Biochem Sci (2006) 0.96
Progress in structure prediction of alpha-helical membrane proteins. Curr Opin Struct Biol (2006) 0.95
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. J Mol Biol (2010) 0.95
A new twist in TCR diversity revealed by a forbidden alphabeta TCR. J Mol Biol (2007) 0.94
Computational design of a pH-sensitive IgG binding protein. Proc Natl Acad Sci U S A (2013) 0.94
Monte Carlo studies of folding, dynamics, and stability in alpha-helices. Biophys J (2005) 0.93
Functional evaluation of autism-associated mutations in NHE9. Nat Commun (2013) 0.93
C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A (2010) 0.92
Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. Biochem J (2012) 0.92
A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. J Biol Chem (2012) 0.92
Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem (2011) 0.91
Structure and flexibility of the C-ring in the electromotor of rotary F(0)F(1)-ATPase of pea chloroplasts. PLoS One (2012) 0.89
Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89
Implicit solvent model estimates of the stability of model structures of the alamethicin channel. Eur Biophys J (2003) 0.89
Computational design of novel protein binders and experimental affinity maturation. Methods Enzymol (2013) 0.89
How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure (2012) 0.88
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating. Biophys J (2010) 0.87
Interactions of cationic-hydrophobic peptides with lipid bilayers: a Monte Carlo simulation method. Biophys J (2007) 0.87
Structural determinants of transmembrane helical proteins. Structure (2009) 0.87
Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol (2008) 0.87
Interactions of the M2delta segment of the acetylcholine receptor with lipid bilayers: a continuum-solvent model study. Biophys J (2003) 0.86
A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85
Generation, comparison, and merging of pathways between protein conformations: gating in K-channels. Biophys J (2008) 0.85
Stability of an ion channel in lipid bilayers: implicit solvent model calculations with gramicidin. Biochemistry (2002) 0.85
Computational design of protein-protein interactions. Curr Opin Struct Biol (2013) 0.85
Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol Biol Cell (2014) 0.85
Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B (2010) 0.85
Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population. Proc Natl Acad Sci U S A (2011) 0.84
Study of MDM2 binding to p53-analogues: affinity, helicity, and applicability to drug design. J Chem Inf Model (2009) 0.83
The structural context of disease-causing mutations in gap junctions. J Biol Chem (2006) 0.82
Computational protein design suggests that human PCNA-partner interactions are not optimized for affinity. Proteins (2012) 0.81
A combined pulse EPR and Monte Carlo simulation study provides molecular insight on peptide-membrane interactions. J Phys Chem B (2009) 0.81
The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem (2013) 0.79
Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins (2003) 0.79
Prediction and simulation of motion in pairs of transmembrane alpha-helices. Bioinformatics (2007) 0.79
Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism. J Biol Chem (2011) 0.79
Interaction of an antimicrobial peptide with membranes: experiments and simulations with NKCS. J Phys Chem B (2010) 0.79
Monte Carlo simulations of peptide-membrane interactions with the MCPep web server. Nucleic Acids Res (2012) 0.79
In silico identification of functional protein interfaces. Comp Funct Genomics (2003) 0.78
Assigning transmembrane segments to helices in intermediate-resolution structures. Bioinformatics (2004) 0.78
Long-range effects on the binding of the influenza HA to receptors are mediated by changes in the stability of a metastable HA conformation. Biochim Biophys Acta (2002) 0.77
Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA. Metallomics (2015) 0.77
The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase. Chembiochem (2009) 0.76
On the regulatory role of dipeptidyl peptidase IV (=CD=adenosine deaminase complexing protein) on adenosine deaminase activity. Biochim Biophys Acta (2002) 0.76
Two new areas were defined: "Metabolic Networks" and "RNA Bioinformatics. Bioinformatics (2013) 0.75