Published in Proc Natl Acad Sci U S A on August 16, 2010
Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits. Proc Natl Acad Sci U S A (2013) 1.28
An electrostatic potassium channel opener targeting the final voltage sensor transition. J Gen Physiol (2011) 1.25
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Res (2013) 1.00
Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits. Mol Pharmacol (2010) 0.99
Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol (2014) 0.95
Atomic basis for therapeutic activation of neuronal potassium channels. Nat Commun (2015) 0.90
Biophysics, pathophysiology, and pharmacology of ion channel gating pores. Front Pharmacol (2014) 0.87
The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants. Front Pharmacol (2011) 0.87
Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proc Natl Acad Sci U S A (2013) 0.86
Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci U S A (2014) 0.86
Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery. Front Pharmacol (2016) 0.86
Potassium channels: a review of broadening therapeutic possibilities for neurological diseases. J Neurol (2012) 0.85
Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. Biophys J (2012) 0.85
Sequence determinants of subtype-specific actions of KCNQ channel openers. J Physiol (2016) 0.85
Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol (2013) 0.84
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clin Pharmacol (2010) 0.83
Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain. J Gen Physiol (2014) 0.83
Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments. Biophys J (2015) 0.82
Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channels. PLoS One (2012) 0.82
Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations. PLoS One (2016) 0.81
Activation of peripheral KCNQ channels relieves gout pain. Pain (2015) 0.80
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels. Acta Pharmacol Sin (2013) 0.79
Free-energy landscape of ion-channel voltage-sensor-domain activation. Proc Natl Acad Sci U S A (2014) 0.78
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques. Acta Pharmacol Sin (2016) 0.78
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels. Front Cell Neurosci (2015) 0.78
Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol (2013) 0.77
Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons. J Neurophysiol (2016) 0.75
The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther (2015) 0.75
Channel gating pore: a new therapeutic target. Cell Res (2013) 0.75
Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability. Sci Rep (2015) 0.75
MAFFT version 5: improvement in accuracy of multiple sequence alignment. Nucleic Acids Res (2005) 31.64
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70
X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
A voltage sensor-domain protein is a voltage-gated proton channel. Science (2006) 5.07
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci (2000) 4.78
Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci (2005) 4.54
LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites. J Mol Graph Model (2003) 3.60
Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling. Proteins (2003) 3.04
Voltage-gated ion channels and gating modifier toxins. Toxicon (2006) 2.77
On the role of the crystal environment in determining protein side-chain conformations. J Mol Biol (2002) 2.73
Sensing voltage across lipid membranes. Nature (2008) 2.66
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43
Voltage-dependent structural interactions in the Shaker K(+) channel. J Gen Physiol (2000) 2.31
The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures. Nucleic Acids Res (2008) 2.04
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci (2005) 2.00
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol (2005) 1.95
Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol (2004) 1.86
Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon (2006) 1.69
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A (2001) 1.57
Functional reconstitution of purified human Hv1 H+ channels. J Mol Biol (2009) 1.50
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels. Mol Pharmacol (2008) 1.42
Ion channel pharmacology. Neurotherapeutics (2007) 1.42
LigScore: a novel scoring function for predicting binding affinities. J Mol Graph Model (2004) 1.38
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol (2007) 1.32
Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release. J Neurophysiol (2006) 1.17
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett (2009) 1.15
PMF scoring revisited. J Med Chem (2006) 1.12
A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives. PLoS One (2007) 1.01
Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit. Biophys J (2008) 0.94
Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site. Mol Pharmacol (2006) 0.90
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res (2010) 9.68
ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics (2003) 7.83
Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics (2002) 4.54
Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol Biol Evol (2004) 3.62
ConSeq: the identification of functionally and structurally important residues in protein sequences. Bioinformatics (2004) 3.50
Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex. Cereb Cortex (2004) 2.56
Comment on "Network motifs: simple building blocks of complex networks" and "Superfamilies of evolved and designed networks". Science (2004) 2.37
Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations. Circ Res (2006) 2.05
The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures. Nucleic Acids Res (2008) 2.04
A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86
Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol (2004) 1.86
The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Proteins (2005) 1.72
A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell (2004) 1.54
Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res (2007) 1.52
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51
Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain. J Mol Biol (2006) 1.47
The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J Biol Chem (2007) 1.45
Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. J Mol Biol (2009) 1.43
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. J Biol Chem (2007) 1.32
Detection of functionally important regions in "hypothetical proteins" of known structure. Structure (2008) 1.31
Pore conformations and gating mechanism of a Cys-loop receptor. Proc Natl Acad Sci U S A (2005) 1.31
A novel scoring function for predicting the conformations of tightly packed pairs of transmembrane alpha-helices. J Mol Biol (2002) 1.29
The C-terminus of Kv7 channels: a multifunctional module. J Physiol (2008) 1.27
Co-evolving residues in membrane proteins. Bioinformatics (2007) 1.25
A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains. Structure (2004) 1.24
Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J (2008) 1.18
The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol (2004) 1.18
In silico identification of functional regions in proteins. Bioinformatics (2005) 1.18
Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release. J Neurophysiol (2006) 1.17
Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem (2003) 1.14
Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys J (2004) 1.14
Transmembrane protein structures without X-rays. Trends Biochem Sci (2006) 1.13
Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem (2011) 1.11
Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors. Biochim Biophys Acta (2007) 1.10
Free diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculations. Biophys J (2004) 1.10
QuasiMotiFinder: protein annotation by searching for evolutionarily conserved motif-like patterns. Nucleic Acids Res (2005) 1.09
KCNE1 constrains the voltage sensor of Kv7.1 K+ channels. PLoS One (2008) 1.08
Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology (2006) 1.08
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Type I chaperonins: not all are created equal. FEBS Lett (2002) 1.05
A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism. Metallomics (2012) 1.05
Diurnal and circadian regulation of putative potassium channels in a leaf moving organ. Plant Physiol (2002) 1.05
New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation. J Chem Inf Model (2012) 1.03
Intracellular domains interactions and gated motions of I(KS) potassium channel subunits. EMBO J (2009) 1.03
Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels. Nat Commun (2011) 1.01
Quality assessment of protein model-structures using evolutionary conservation. Bioinformatics (2010) 1.01
A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives. PLoS One (2007) 1.01
An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data. Biophys J (2004) 1.00
Enzymatic activation of second-generation dendritic prodrugs: Conjugation of self-immolative dendrimers with poly(ethylene glycol) via click chemistry. Bioconjug Chem (2006) 1.00
An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. J Mol Biol (2004) 1.00
Interactions of hydrophobic peptides with lipid bilayers: Monte Carlo simulations with M2delta. Biophys J (2003) 1.00
iDBPs: a web server for the identification of DNA binding proteins. Bioinformatics (2010) 0.98
An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophys J (2007) 0.98
Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Mol Biol Cell (2006) 0.98
Has the code for protein translocation been broken? Trends Biochem Sci (2006) 0.96
MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. Nucleic Acids Res (2010) 0.96
External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol (2004) 0.96
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. J Mol Biol (2010) 0.95
Progress in structure prediction of alpha-helical membrane proteins. Curr Opin Struct Biol (2006) 0.95
W-Band pulse EPR distance measurements in peptides using Gd(3+)-dipicolinic acid derivatives as spin labels. Phys Chem Chem Phys (2011) 0.95
Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels. Circ Res (2008) 0.95
S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels. PLoS One (2008) 0.94
Monte Carlo studies of folding, dynamics, and stability in alpha-helices. Biophys J (2005) 0.93
Modulation of homomeric and heteromeric KCNQ1 channels by external acidification. J Physiol (2002) 0.93
Functional evaluation of autism-associated mutations in NHE9. Nat Commun (2013) 0.93
C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A (2010) 0.92
Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. Biochem J (2012) 0.92
Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations. Ann Noninvasive Electrocardiol (2002) 0.92
A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. J Biol Chem (2012) 0.92
Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem (2011) 0.91
Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter. J Biol Chem (2006) 0.90
Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity. PLoS One (2009) 0.89
Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89
Structure and flexibility of the C-ring in the electromotor of rotary F(0)F(1)-ATPase of pea chloroplasts. PLoS One (2012) 0.89
Implicit solvent model estimates of the stability of model structures of the alamethicin channel. Eur Biophys J (2003) 0.89
How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure (2012) 0.88
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating. Biophys J (2010) 0.87
Structural determinants of transmembrane helical proteins. Structure (2009) 0.87
Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol (2008) 0.87
Interactions of cationic-hydrophobic peptides with lipid bilayers: a Monte Carlo simulation method. Biophys J (2007) 0.87
Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. Structure (2014) 0.87
Interactions of the M2delta segment of the acetylcholine receptor with lipid bilayers: a continuum-solvent model study. Biophys J (2003) 0.86
PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Am J Physiol Cell Physiol (2003) 0.86
A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85
Generation, comparison, and merging of pathways between protein conformations: gating in K-channels. Biophys J (2008) 0.85
Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol Biol Cell (2014) 0.85
Stability of an ion channel in lipid bilayers: implicit solvent model calculations with gramicidin. Biochemistry (2002) 0.85
SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2013) 0.85
Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B (2010) 0.85