Published in Structure on December 10, 2008
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res (2010) 9.68
Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure. PLoS Comput Biol (2009) 2.82
Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. J Mol Biol (2009) 1.43
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules. Nucleic Acids Res (2016) 1.18
Quality assessment of protein model-structures using evolutionary conservation. Bioinformatics (2010) 1.01
iDBPs: a web server for the identification of DNA binding proteins. Bioinformatics (2010) 0.98
Sequence and structure continuity of evolutionary importance improves protein functional site discovery and annotation. Protein Sci (2010) 0.96
Detecting patches of protein sites of influenza A viruses under positive selection. Mol Biol Evol (2012) 0.95
DNABINDPROT: fluctuation-based predictor of DNA-binding residues within a network of interacting residues. Nucleic Acids Res (2010) 0.92
Functional annotation of conserved hypothetical proteins from Haemophilus influenzae Rd KW20. PLoS One (2013) 0.88
SDS, a structural disruption score for assessment of missense variant deleteriousness. Front Genet (2014) 0.82
Identification of recurring protein structure microenvironments and discovery of novel functional sites around CYS residues. BMC Struct Biol (2010) 0.82
Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family. BMC Struct Biol (2011) 0.82
Functional region prediction with a set of appropriate homologous sequences--an index for sequence selection by integrating structure and sequence information with spatial statistics. BMC Struct Biol (2012) 0.79
Structural analysis of hypothetical proteins from Helicobacter pylori: an approach to estimate functions of unknown or hypothetical proteins. Int J Mol Sci (2012) 0.77
Analysis of spatial and temporal protein expression in the cerebral cortex after ischemia-reperfusion injury. J Clin Neurol (2014) 0.77
Towards New Drug Targets? Function Prediction of Putative Proteins of Neisseria meningitidis MC58 and Their Virulence Characterization. OMICS (2015) 0.76
An association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretation. BioData Min (2013) 0.76
DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex's Dynamics. PLoS Comput Biol (2015) 0.76
Structure-based functional annotation of putative conserved proteins having lyase activity from Haemophilus influenzae. 3 Biotech (2014) 0.75
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res (2010) 9.68
ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics (2003) 7.83
Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics (2002) 4.54
Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol Biol Evol (2004) 3.62
ConSeq: the identification of functionally and structurally important residues in protein sequences. Bioinformatics (2004) 3.50
Comment on "Network motifs: simple building blocks of complex networks" and "Superfamilies of evolved and designed networks". Science (2004) 2.37
The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures. Nucleic Acids Res (2008) 2.04
A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86
The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Proteins (2005) 1.72
Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. Blood (2008) 1.57
Statistical education for medical students--concepts are what remain when the details are forgotten. Stat Med (2007) 1.55
A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell (2004) 1.54
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51
Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain. J Mol Biol (2006) 1.47
The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction. Am J Obstet Gynecol (2004) 1.44
Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. J Mol Biol (2009) 1.43
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. Clin Cancer Res (2009) 1.39
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. J Biol Chem (2007) 1.32
A novel scoring function for predicting the conformations of tightly packed pairs of transmembrane alpha-helices. J Mol Biol (2002) 1.29
Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. Thromb Haemost (2010) 1.27
Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. Proc Natl Acad Sci U S A (2010) 1.26
Co-evolving residues in membrane proteins. Bioinformatics (2007) 1.25
A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains. Structure (2004) 1.24
Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J (2008) 1.18
In silico identification of functional regions in proteins. Bioinformatics (2005) 1.18
The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol (2004) 1.18
Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys J (2004) 1.14
Transmembrane protein structures without X-rays. Trends Biochem Sci (2006) 1.13
Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors. Biochim Biophys Acta (2007) 1.10
Free diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculations. Biophys J (2004) 1.10
QuasiMotiFinder: protein annotation by searching for evolutionarily conserved motif-like patterns. Nucleic Acids Res (2005) 1.09
Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology (2006) 1.08
Intra- and interobserver reliability analysis of digital radiographic measurements for pediatric orthopedic parameters using a novel PACS integrated computer software program. J Child Orthop (2010) 1.07
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Type I chaperonins: not all are created equal. FEBS Lett (2002) 1.05
A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism. Metallomics (2012) 1.05
New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation. J Chem Inf Model (2012) 1.03
Quality assessment of protein model-structures using evolutionary conservation. Bioinformatics (2010) 1.01
An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. J Mol Biol (2004) 1.00
An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data. Biophys J (2004) 1.00
Interactions of hydrophobic peptides with lipid bilayers: Monte Carlo simulations with M2delta. Biophys J (2003) 1.00
iDBPs: a web server for the identification of DNA binding proteins. Bioinformatics (2010) 0.98
Has the code for protein translocation been broken? Trends Biochem Sci (2006) 0.96
MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. Nucleic Acids Res (2010) 0.96
Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency. Blood (2003) 0.95
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. J Mol Biol (2010) 0.95
Progress in structure prediction of alpha-helical membrane proteins. Curr Opin Struct Biol (2006) 0.95
Monte Carlo studies of folding, dynamics, and stability in alpha-helices. Biophys J (2005) 0.93
Functional evaluation of autism-associated mutations in NHE9. Nat Commun (2013) 0.93
C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A (2010) 0.92
Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. Biochem J (2012) 0.92
A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. J Biol Chem (2012) 0.92
Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem (2011) 0.91
Inflammatory pseudotumor: a diagnostic dilemma in cytopathology. Diagn Cytopathol (2004) 0.91
Role of socioeconomic status measures in long-term mortality risk prediction after myocardial infarction. Med Care (2011) 0.90
Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency. Blood Coagul Fibrinolysis (2005) 0.89
Structure and flexibility of the C-ring in the electromotor of rotary F(0)F(1)-ATPase of pea chloroplasts. PLoS One (2012) 0.89
Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89
Implicit solvent model estimates of the stability of model structures of the alamethicin channel. Eur Biophys J (2003) 0.89
How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure (2012) 0.88
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating. Biophys J (2010) 0.87
Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol (2008) 0.87
Structural determinants of transmembrane helical proteins. Structure (2009) 0.87
Interactions of cationic-hydrophobic peptides with lipid bilayers: a Monte Carlo simulation method. Biophys J (2007) 0.87
Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel. Br J Haematol (2004) 0.86
Interactions of the M2delta segment of the acetylcholine receptor with lipid bilayers: a continuum-solvent model study. Biophys J (2003) 0.86
A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85
Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B (2010) 0.85
Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol Biol Cell (2014) 0.85
Stability of an ion channel in lipid bilayers: implicit solvent model calculations with gramicidin. Biochemistry (2002) 0.85
Generation, comparison, and merging of pathways between protein conformations: gating in K-channels. Biophys J (2008) 0.85
Solitary fibrous tumor of the thyroid: cytopathologic findings and differential diagnosis. Diagn Cytopathol (2003) 0.84
Cumulative exposure to particulate matter air pollution and long-term post-myocardial infarction outcomes. Prev Med (2013) 0.84
Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population. Proc Natl Acad Sci U S A (2011) 0.84
Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene. Ophthalmology (2004) 0.83
Study of MDM2 binding to p53-analogues: affinity, helicity, and applicability to drug design. J Chem Inf Model (2009) 0.83
The structural context of disease-causing mutations in gap junctions. J Biol Chem (2006) 0.82
The impact of enrollment in clinical trials on survival of patients with glioblastoma. J Clin Neurosci (2012) 0.82
Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion. Blood Coagul Fibrinolysis (2006) 0.81
Prevalence of bowlegs among child and adolescent soccer players. Clin J Sport Med (2006) 0.81
A combined pulse EPR and Monte Carlo simulation study provides molecular insight on peptide-membrane interactions. J Phys Chem B (2009) 0.81
Acute lymphoblastic leukemia in children: correlation of musculoskeletal manifestations and immunophenotypes. J Child Orthop (2007) 0.81
The contribution of an electronic conductivity device to the safety of pedicle screw insertion in scoliosis surgery. Spine (Phila Pa 1976) (2011) 0.81
Association of common thrombophilias and antiphospholipid antibodies with success rate of in vitro fertilisation. Thromb Haemost (2012) 0.81
Cumulative exposure to air pollution and long term outcomes after first acute myocardial infarction: a population-based cohort study. Objectives and methodology. BMC Public Health (2010) 0.80
Ethnic differences in patterns of secondhand smoke exposure among adolescents in Israel. Nicotine Tob Res (2012) 0.80
The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem (2013) 0.79
Monte Carlo simulations of peptide-membrane interactions with the MCPep web server. Nucleic Acids Res (2012) 0.79
Vigilance, awareness and a phone line: 20 years of expediting CPR for enhancing survival after out-of-hospital cardiac arrest. The 'SHL'-Telemedicine experience in Israel. Resuscitation (2008) 0.79
Cell free expression of hif1α and p21 in maternal peripheral blood as a marker for preeclampsia and fetal growth restriction. PLoS One (2012) 0.79
Prediction and simulation of motion in pairs of transmembrane alpha-helices. Bioinformatics (2007) 0.79
Socioeconomic environment and recurrent coronary events after initial myocardial infarction. Ann Epidemiol (2012) 0.79
Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism. J Biol Chem (2011) 0.79
Interaction of an antimicrobial peptide with membranes: experiments and simulations with NKCS. J Phys Chem B (2010) 0.79
Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins (2003) 0.79