Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 2872368)

Published in Biophys J on May 19, 2010

Authors

Adva Yeheskel1, Turkan Haliloglu, Nir Ben-Tal

Author Affiliations

1: Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.

Articles cited by this

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70

X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35

Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential. Fold Des (1997) 11.73

Anisotropy of fluctuation dynamics of proteins with an elastic network model. Biophys J (2001) 9.04

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron (1996) 8.20

Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron (1996) 8.11

Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J Gen Physiol (1994) 7.23

The principle of gating charge movement in a voltage-dependent K+ channel. Nature (2003) 6.94

Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85

Molecular basis of charge movement in voltage-gated sodium channels. Neuron (1996) 6.61

A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature (2004) 5.66

Gated access to the pore of a voltage-dependent K+ channel. Neuron (1997) 5.45

A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J Gen Physiol (1998) 4.56

Evidence for voltage-dependent S4 movement in sodium channels. Neuron (1995) 4.21

Coarse-grained normal mode analysis in structural biology. Curr Opin Struct Biol (2005) 3.88

Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science (2004) 3.59

ConSeq: the identification of functionally and structurally important residues in protein sequences. Bioinformatics (2004) 3.50

Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol (1999) 3.42

Energetics of pore opening in a voltage-gated K(+) channel. Cell (2002) 3.36

Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proc Natl Acad Sci U S A (2005) 3.25

The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron (1993) 3.15

How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05

Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature (2005) 2.98

Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron (1998) 2.98

Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81

Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol (2007) 2.64

Evidence for cooperative interactions in potassium channel gating. Nature (1992) 2.61

Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43

The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel. Neuron (2006) 2.25

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol (2009) 2.12

The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature (2006) 2.10

Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00

Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins. Chem Rev (2010) 1.98

The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol (2005) 1.89

HingeProt: automated prediction of hinges in protein structures. Proteins (2008) 1.86

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85

Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83

Global twisting motion of single molecular KcsA potassium channel upon gating. Cell (2008) 1.81

Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol (2006) 1.71

Dynamical properties of the MscL of Escherichia coli: a normal mode analysis. J Mol Biol (2003) 1.66

Specificity of charge-carrying residues in the voltage sensor of potassium channels. J Gen Physiol (2004) 1.60

Probing the outer vestibule of a sodium channel voltage sensor. Biophys J (1997) 1.59

Voltage sensor movements. J Gen Physiol (2002) 1.59

Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel. PLoS Comput Biol (2009) 1.51

Stirring up controversy with a voltage sensor paddle. Trends Neurosci (2004) 1.50

ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1996) 1.43

Extent of voltage sensor movement during gating of shaker K+ channels. Neuron (2008) 1.42

Common mechanism of pore opening shared by five different potassium channels. Biophys J (2006) 1.40

A single charged voltage sensor is capable of gating the Shaker K+ channel. J Gen Physiol (2009) 1.35

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem (1999) 1.33

Jervell and Lange-Nielsen syndrome: a Norwegian perspective. Am J Med Genet (1999) 1.28

Models of the structure and voltage-gating mechanism of the shaker K+ channel. Biophys J (2004) 1.24

Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion. Neuron (2008) 1.22

Open-state conformation of the KcsA K+ channel: Monte Carlo normal mode following simulations. Structure (2007) 1.12

Inferred motions of the S3a helix during voltage-dependent K+ channel gating. J Mol Biol (2008) 1.11

Direct analysis of cooperativity in multisubunit allosteric proteins. Proc Natl Acad Sci U S A (2008) 1.07

Effect of cysteine substitutions on the topology of the S4 segment of the Shaker potassium channel: implications for molecular models of gating. J Physiol (1999) 1.02

Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure. J Gen Physiol (2008) 1.02

An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. J Mol Biol (2004) 1.00

Potassium channelopathies. Neuropharmacology (1997) 0.91

Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. J Gen Physiol (2005) 0.88

Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol (2008) 0.87

Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels. J Biol Chem (2008) 0.80

Articles by these authors

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res (2010) 9.68

ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics (2003) 7.83

Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics (2002) 4.54

Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol Biol Evol (2004) 3.62

ConSeq: the identification of functionally and structurally important residues in protein sequences. Bioinformatics (2004) 3.50

Comment on "Network motifs: simple building blocks of complex networks" and "Superfamilies of evolved and designed networks". Science (2004) 2.37

The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures. Nucleic Acids Res (2008) 2.04

A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86

HingeProt: automated prediction of hinges in protein structures. Proteins (2008) 1.86

The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Proteins (2005) 1.72

A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell (2004) 1.54

Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51

Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain. J Mol Biol (2006) 1.47

Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. J Mol Biol (2009) 1.43

Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. J Biol Chem (2007) 1.32

Detection of functionally important regions in "hypothetical proteins" of known structure. Structure (2008) 1.31

A novel scoring function for predicting the conformations of tightly packed pairs of transmembrane alpha-helices. J Mol Biol (2002) 1.29

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. Proc Natl Acad Sci U S A (2010) 1.26

Co-evolving residues in membrane proteins. Bioinformatics (2007) 1.25

A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains. Structure (2004) 1.24

Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J (2008) 1.18

In silico identification of functional regions in proteins. Bioinformatics (2005) 1.18

The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol (2004) 1.18

Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys J (2004) 1.14

Transmembrane protein structures without X-rays. Trends Biochem Sci (2006) 1.13

Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations. Proteins (2003) 1.12

Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors. Biochim Biophys Acta (2007) 1.10

Free diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculations. Biophys J (2004) 1.10

QuasiMotiFinder: protein annotation by searching for evolutionarily conserved motif-like patterns. Nucleic Acids Res (2005) 1.09

Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology (2006) 1.08

A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07

Type I chaperonins: not all are created equal. FEBS Lett (2002) 1.05

A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism. Metallomics (2012) 1.05

New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation. J Chem Inf Model (2012) 1.03

Quality assessment of protein model-structures using evolutionary conservation. Bioinformatics (2010) 1.01

An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. J Mol Biol (2004) 1.00

An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data. Biophys J (2004) 1.00

Interactions of hydrophobic peptides with lipid bilayers: Monte Carlo simulations with M2delta. Biophys J (2003) 1.00

iDBPs: a web server for the identification of DNA binding proteins. Bioinformatics (2010) 0.98

Has the code for protein translocation been broken? Trends Biochem Sci (2006) 0.96

MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. Nucleic Acids Res (2010) 0.96

Conformational transition pathways explored by Monte Carlo simulation integrated with collective modes. Biophys J (2008) 0.95

Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. J Mol Biol (2010) 0.95

Progress in structure prediction of alpha-helical membrane proteins. Curr Opin Struct Biol (2006) 0.95

Monte Carlo studies of folding, dynamics, and stability in alpha-helices. Biophys J (2005) 0.93

Functional evaluation of autism-associated mutations in NHE9. Nat Commun (2013) 0.93

C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A (2010) 0.92

Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. Biochem J (2012) 0.92

DNABINDPROT: fluctuation-based predictor of DNA-binding residues within a network of interacting residues. Nucleic Acids Res (2010) 0.92

A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. J Biol Chem (2012) 0.92

Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem (2011) 0.91

Structure and flexibility of the C-ring in the electromotor of rotary F(0)F(1)-ATPase of pea chloroplasts. PLoS One (2012) 0.89

Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89

Implicit solvent model estimates of the stability of model structures of the alamethicin channel. Eur Biophys J (2003) 0.89

How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure (2012) 0.88

Interactions of cationic-hydrophobic peptides with lipid bilayers: a Monte Carlo simulation method. Biophys J (2007) 0.87

Structural determinants of transmembrane helical proteins. Structure (2009) 0.87

Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol (2008) 0.87

Interactions of the M2delta segment of the acetylcholine receptor with lipid bilayers: a continuum-solvent model study. Biophys J (2003) 0.86

Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis. Nucleic Acids Res (2008) 0.86

A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85

Generation, comparison, and merging of pathways between protein conformations: gating in K-channels. Biophys J (2008) 0.85

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol Biol Cell (2014) 0.85

Stability of an ion channel in lipid bilayers: implicit solvent model calculations with gramicidin. Biochemistry (2002) 0.85

Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B (2010) 0.85

Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease. Biophys J (2010) 0.85

Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population. Proc Natl Acad Sci U S A (2011) 0.84

Association of putative concave protein-binding sites with the fluctuation behavior of residues. Protein Sci (2006) 0.84

MCPath: Monte Carlo path generation approach to predict likely allosteric pathways and functional residues. Nucleic Acids Res (2013) 0.83

Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease. Biophys J (2003) 0.83

Study of MDM2 binding to p53-analogues: affinity, helicity, and applicability to drug design. J Chem Inf Model (2009) 0.83

The structural context of disease-causing mutations in gap junctions. J Biol Chem (2006) 0.82

A combined pulse EPR and Monte Carlo simulation study provides molecular insight on peptide-membrane interactions. J Phys Chem B (2009) 0.81

Cooperative fluctuations point to the dimerization interface of p53 core domain. Biophys J (2006) 0.80

Hot spots in a network of functional sites. PLoS One (2013) 0.80

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem (2013) 0.79

Interaction of an antimicrobial peptide with membranes: experiments and simulations with NKCS. J Phys Chem B (2010) 0.79

Monte Carlo simulations of peptide-membrane interactions with the MCPep web server. Nucleic Acids Res (2012) 0.79

Prediction and simulation of motion in pairs of transmembrane alpha-helices. Bioinformatics (2007) 0.79

Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism. J Biol Chem (2011) 0.79

Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins (2003) 0.79

In silico identification of functional protein interfaces. Comp Funct Genomics (2003) 0.78

Assigning transmembrane segments to helices in intermediate-resolution structures. Bioinformatics (2004) 0.78

Substrate specificity in HIV-1 protease by a biased sequence search method. Proteins (2006) 0.78

Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA. Metallomics (2015) 0.77

Long-range effects on the binding of the influenza HA to receptors are mediated by changes in the stability of a metastable HA conformation. Biochim Biophys Acta (2002) 0.77

The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase. Chembiochem (2009) 0.76

On the regulatory role of dipeptidyl peptidase IV (=CD=adenosine deaminase complexing protein) on adenosine deaminase activity. Biochim Biophys Acta (2002) 0.76

Two new areas were defined: "Metabolic Networks" and "RNA Bioinformatics. Bioinformatics (2013) 0.75

What can we learn from highly connected beta-rich structures for structural interface design? Methods Mol Biol (2008) 0.75