Published in J Mol Biol on January 28, 2005
Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (2008) 1.75
Interaction and conformational dynamics of membrane-spanning protein helices. Protein Sci (2009) 1.19
The E5 proteins. Virology (2013) 1.11
The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango. Virology (2008) 1.07
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A (2010) 0.92
Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor. Proc Natl Acad Sci U S A (2007) 0.90
Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction. J Virol (2013) 0.85
A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes. Immunogenetics (2010) 0.84
Viral miniproteins. Annu Rev Microbiol (2014) 0.82
Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering. Protein Eng Des Sel (2010) 0.79
De novo selection of oncogenes. Proc Natl Acad Sci U S A (2013) 0.78
A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor. J Biol Chem (2013) 0.77
Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One (2014) 0.75
Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions. Elife (2017) 0.75
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet (2009) 3.80
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A (2004) 2.44
Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A (2006) 2.36
Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol (2003) 2.32
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
Membrane protein folding: beyond the two stage model. FEBS Lett (2003) 2.20
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06
Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol (2002) 1.85
Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Proc Natl Acad Sci U S A (2005) 1.73
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71
Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J (2003) 1.51
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50
Protein area occupancy at the center of the red blood cell membrane. Proc Natl Acad Sci U S A (2008) 1.49
Dynamic helix interactions in transmembrane signaling. Cell (2006) 1.49
Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol (2002) 1.47
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J Biol Chem (2003) 1.41
pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.38
Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res (2004) 1.32
Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol (2004) 1.32
Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys (2004) 1.31
Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29
Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29
Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function. Annu Rev Biochem (2006) 1.27
An integrated system for studying residue coevolution in proteins. Bioinformatics (2007) 1.25
Bacteriorhodopsin/amphipol complexes: structural and functional properties. Biophys J (2008) 1.24
GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J Biol Chem (2002) 1.23
pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19
Computational analysis of membrane proteins: the largest class of drug targets. Drug Discov Today (2009) 1.19
pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem (2004) 1.16
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi (2009) 1.16
BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio (2011) 1.16
Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families. Genome Res (2010) 1.13
Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10
Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices. Biophys J (2004) 1.10
In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol (2012) 1.09
Mutational analysis of synaptobrevin transmembrane domain oligomerization. Biochemistry (2002) 1.09
Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol (2004) 1.08
Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism. Proc Natl Acad Sci U S A (2004) 1.06
The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol (2006) 1.04
Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol (2003) 1.02
Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol (2011) 1.02
Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. FASEB J (2011) 1.00
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett (2005) 0.99
Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor. J Virol (2005) 0.96
pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96
Evidence for role of transmembrane helix-helix interactions in the assembly of the Class II major histocompatibility complex. Mol Biosyst (2010) 0.95
Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry (2006) 0.92
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A (2010) 0.92
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91
Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions. Biochim Biophys Acta (2009) 0.90
Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90
Modulation of cell function by small transmembrane proteins modeled on the bovine papillomavirus E5 protein. Oncogene (2005) 0.90
Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor. Proc Natl Acad Sci U S A (2007) 0.90
The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology (2010) 0.89
In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain. Biochemistry (2008) 0.89
Contributions of the transmembrane domain and a key acidic motif to assembly and function of the TatA complex. J Mol Biol (2009) 0.87
Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A (2012) 0.87
Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs. J Biol Chem (2009) 0.87
Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta (2009) 0.87
pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86
B-Myb, cancer, senescence, and microRNAs. Cancer Res (2011) 0.86
High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology (2013) 0.83
Sequence-dependent oligomerization of the Neu transmembrane domain suggests inhibition of "conformational switching" by an oncogenic mutant. Biochemistry (2010) 0.83
Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. J Virol (2013) 0.83
Thermostability of membrane protein helix-helix interaction elucidated by statistical analysis. FEBS Lett (2002) 0.82
Towards a structural understanding of the smallest known oncoprotein: investigation of the bovine papillomavirus E5 protein using solution-state NMR. Biochim Biophys Acta (2010) 0.82
Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng (2002) 0.81
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments. J Biol Chem (2013) 0.80
Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering. Protein Eng Des Sel (2010) 0.79
Effects of the oncogenic V(664)E mutation on membrane insertion, structure, and sequence-dependent interactions of the Neu transmembrane domain in micelles and model membranes: an integrated biophysical and simulation study. Biochemistry (2012) 0.78
Helical membrane peptides to modulate cell function. Chem Soc Rev (2010) 0.78
Packing of transmembrane domain 2 of carnitine palmitoyltransferase-1A affects oligomerization and malonyl-CoA sensitivity of the mitochondrial outer membrane protein. FASEB J (2011) 0.78
Applications of pHLIP Technology for Cancer Imaging and Therapy: (Trends in Biotechnology 35, 653-664, 2017). Trends Biotechnol (2017) 0.75
Direct assignment of the absolute configuration of a distinct class of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus by M-GOESY nuclear magnetic resonance spectroscopy. J Am Chem Soc (2002) 0.75