In vivo pH imaging with (99m)Tc-pHLIP.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 3909815)

Published in Mol Imaging Biol on December 01, 2012

Authors

Sven Macholl1, Matthew S Morrison, Peter Iveson, Bente E Arbo, Oleg A Andreev, Yana K Reshetnyak, Donald M Engelman, Edvin Johannesen

Author Affiliations

1: Medical Diagnostics, The Grove Centre, GE Healthcare, GC/18, Amersham HP7 9LL, UK. sven.macholl@ge.com

Articles citing this

Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31

pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19

Targeting pancreatic ductal adenocarcinoma acidic microenvironment. Sci Rep (2014) 1.07

pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96

pHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J Control Release (2013) 0.95

Targeting breast tumors with pH (low) insertion peptides. Mol Pharm (2014) 0.94

Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94

pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci Rep (2013) 0.91

Advanced targeted nanomedicine. J Biotechnol (2015) 0.87

Stimuli-responsive nanoparticles for targeting the tumor microenvironment. J Control Release (2015) 0.85

Probe for the measurement of cell surface pH in vivo and ex vivo. Proc Natl Acad Sci U S A (2016) 0.82

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A (2015) 0.81

Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys (2014) 0.77

pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. Oncotarget (2015) 0.76

Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance. Nat Commun (2015) 0.75

Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging. Front Oncol (2017) 0.75

pH-Dependent Cellular Internalization of Paramagnetic Nanoparticle. ACS Sens (2016) 0.75

Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe. Appl Magn Reson (2014) 0.75

Articles cited by this

Hallmarks of cancer: the next generation. Cell (2011) 140.01

On the origin of cancer cells. Science (1956) 49.55

Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60

AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging (2003) 8.56

LNCaP model of human prostatic carcinoma. Cancer Res (1983) 7.23

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature (2008) 5.60

Causes and consequences of increased glucose metabolism of cancers. J Nucl Med (2008) 3.79

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res (2006) 3.10

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45

Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A (2006) 2.36

A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res (2002) 2.29

Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry (1997) 2.11

A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06

31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol (1994) 2.00

Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer (1999) 1.79

Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture. Cancer Lett (1980) 1.68

Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous (19)F and (31)P probes. NMR Biomed (1999) 1.58

Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50

An assessment of 31P MRS as a method of measuring pH in rat tumours. NMR Biomed (1993) 1.45

Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy. Cancer Res (2007) 1.45

PERTECHNETATE-99M LOCALIZATION IN MAN WITH APPLICATIONS TO THYROID SCANNING AND THE STUDY OF THYROID PHYSIOLOGY. J Clin Endocrinol Metab (1965) 1.37

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29

Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft. Cancer Res (2009) 1.27

Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10

99mTc-NC100692--a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigation. Nucl Med Biol (2008) 0.99

The future of SPECT in a time of PET. Nucl Med Biol (2007) 0.97

Chromosomal analysis of human prostatic adenocarcinoma cell lines. Cancer Res (1980) 0.88

A method for calculating the distribution of pH in tissues and a new source of pH error from the 31P-NMR spectrum. Am J Physiol (1994) 0.84

alpha - and beta -phosphorylated amines and pyrrolidines, a new class of low toxic highly sensitive 31P NMR pH indicators. Modeling of pKa and chemical shift values as a function of substituents. J Biol Chem (2000) 0.82

Tumor imaging using technetium-99m bound to pH-sensitive peptides. Nanomedicine (2007) 0.79

Articles by these authors

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A (2004) 2.44

Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A (2006) 2.36

Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol (2003) 2.32

A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30

Membrane protein folding: beyond the two stage model. FEBS Lett (2003) 2.20

Three methods for 18F labeling of the HER2-binding affibody molecule Z(HER2:2891) including preclinical assessment. J Nucl Med (2013) 2.17

Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled αVbeta3-integrin and αV beta5-integrin imaging agent. J Nucl Med (2011) 2.11

A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06

Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol (2002) 1.85

Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71

Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J (2003) 1.51

Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50

Protein area occupancy at the center of the red blood cell membrane. Proc Natl Acad Sci U S A (2008) 1.49

Dynamic helix interactions in transmembrane signaling. Cell (2006) 1.49

Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol (2002) 1.47

pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42

Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J Biol Chem (2003) 1.41

pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.38

Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol (2004) 1.32

Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys (2004) 1.31

Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29

Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29

Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function. Annu Rev Biochem (2006) 1.27

An integrated system for studying residue coevolution in proteins. Bioinformatics (2007) 1.25

Bacteriorhodopsin/amphipol complexes: structural and functional properties. Biophys J (2008) 1.24

GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J Biol Chem (2002) 1.23

Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem (2012) 1.23

pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19

Computational analysis of membrane proteins: the largest class of drug targets. Drug Discov Today (2009) 1.19

The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem (2004) 1.16

pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16

Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi (2009) 1.16

Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families. Genome Res (2010) 1.13

Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10

Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices. Biophys J (2004) 1.10

Mutational analysis of synaptobrevin transmembrane domain oligomerization. Biochemistry (2002) 1.09

Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol (2004) 1.08

Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07

Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism. Proc Natl Acad Sci U S A (2004) 1.06

The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol (2006) 1.04

Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol (2003) 1.02

Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol (2011) 1.02

Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01

Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. FASEB J (2011) 1.00

Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett (2005) 0.99

The protein fluorescence and structural toolkit: Database and programs for the analysis of protein fluorescence and structural data. Proteins (2008) 0.99

pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96

pHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J Control Release (2013) 0.95

Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor. J Mol Biol (2005) 0.95

Targeting breast tumors with pH (low) insertion peptides. Mol Pharm (2014) 0.94

Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94

Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. J Virol (2009) 0.93

Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry (2006) 0.92

Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A (2010) 0.92

The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91

Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90

Folding kinetics and structure of OEP16. Biophys J (2004) 0.90

Topography studies on the membrane interaction mechanism of the eosinophil cationic protein. Biochemistry (2007) 0.90

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology (2010) 0.89

Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta (2009) 0.87

Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A (2012) 0.87

pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86