Published in Proc Natl Acad Sci U S A on November 03, 2010
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A (2014) 1.65
Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo. ACS Nano (2012) 1.56
Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids (2011) 1.45
Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31
Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00
pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96
pH-controlled delivery of luminescent europium coated nanoparticles into platelets. Proc Natl Acad Sci U S A (2012) 0.96
Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94
Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90
Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity. Angew Chem Int Ed Engl (2015) 0.89
Advanced targeted nanomedicine. J Biotechnol (2015) 0.87
Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A (2012) 0.87
pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86
Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Mol Pharm (2015) 0.85
Stimuli-responsive nanoparticles for targeting the tumor microenvironment. J Control Release (2015) 0.85
The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A (2015) 0.81
Chiral vibrational structures of proteins at interfaces probed by sum frequency generation spectroscopy. Int J Mol Sci (2011) 0.81
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death. Biochem J (2015) 0.80
A "Smart" ¹²⁸Xe NMR Biosensor for pH-Dependent Cell Labeling. J Am Chem Soc (2015) 0.78
pHLIP Peptide Interaction with a Membrane Monitored by SAXS. J Phys Chem B (2016) 0.78
Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys (2014) 0.77
Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules (2013) 0.77
pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. Sci Rep (2016) 0.77
pHLIP and acidity as a universal biomarker for cancer. Yale J Biol Med (2012) 0.77
Kinetics of peptide folding in lipid membranes. Biopolymers (2015) 0.77
Enhancement of radiation effect on cancer cells by gold-pHLIP. Proc Natl Acad Sci U S A (2015) 0.77
Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation. ACS Chem Biol (2015) 0.77
Membrane binding and insertion of a pHLIP peptide studied by all-atom molecular dynamics simulations. Int J Mol Sci (2013) 0.76
Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells & Mouse Models. Mol Pharm (2017) 0.75
Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide. Chembiochem (2015) 0.75
Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance. Nat Commun (2015) 0.75
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer (2005) 16.73
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res (1986) 15.83
Drug delivery systems: entering the mainstream. Science (2004) 9.27
Fluorescent phallotoxin, a tool for the visualization of cellular actin. Proc Natl Acad Sci U S A (1979) 6.94
Transport of molecules in the tumor interstitium: a review. Cancer Res (1987) 5.74
Counting cytokinesis proteins globally and locally in fission yeast. Science (2005) 5.20
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res (1994) 3.84
Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer (2002) 3.75
Modification of actins by phallotoxins. Naturwissenschaften (1977) 3.38
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res (1996) 3.11
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc Natl Acad Sci U S A (1977) 2.77
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur J Pharm Biopharm (2008) 2.71
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. Annu Rev Biomed Eng (2006) 2.39
Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A (2006) 2.36
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry (1997) 2.11
Tumor pH and its measurement. J Nucl Med (2010) 2.08
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06
Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol (2009) 1.97
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71
Is anticancer drug development heading in the right direction? Cancer Res (2009) 1.56
Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52
Transient kinetic analysis of rhodamine phalloidin binding to actin filaments. Biochemistry (1994) 1.51
The dissociation of the phalloidin-actin complex. Hoppe Seylers Z Physiol Chem (1977) 1.43
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42
F- and G-actin concentrations in lamellipodia of moving cells. PLoS One (2009) 1.41
Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29
pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16
Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07
Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res (2009) 1.00
Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma. Cancer Chemother Pharmacol (2003) 0.89
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A (2004) 2.44
Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A (2006) 2.36
Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol (2003) 2.32
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
Membrane protein folding: beyond the two stage model. FEBS Lett (2003) 2.20
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06
Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol (2002) 1.85
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71
Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J (2003) 1.51
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50
Protein area occupancy at the center of the red blood cell membrane. Proc Natl Acad Sci U S A (2008) 1.49
Dynamic helix interactions in transmembrane signaling. Cell (2006) 1.49
Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol (2002) 1.47
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J Biol Chem (2003) 1.41
Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol (2004) 1.32
Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys (2004) 1.31
Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29
Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29
Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function. Annu Rev Biochem (2006) 1.27
An integrated system for studying residue coevolution in proteins. Bioinformatics (2007) 1.25
Bacteriorhodopsin/amphipol complexes: structural and functional properties. Biophys J (2008) 1.24
GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J Biol Chem (2002) 1.23
Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem (2012) 1.23
pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19
Computational analysis of membrane proteins: the largest class of drug targets. Drug Discov Today (2009) 1.19
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem (2004) 1.16
pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi (2009) 1.16
Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families. Genome Res (2010) 1.13
Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10
Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices. Biophys J (2004) 1.10
In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol (2012) 1.09
Mutational analysis of synaptobrevin transmembrane domain oligomerization. Biochemistry (2002) 1.09
Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol (2004) 1.08
Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism. Proc Natl Acad Sci U S A (2004) 1.06
The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol (2006) 1.04
Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol (2003) 1.02
Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol (2011) 1.02
Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. FASEB J (2011) 1.00
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett (2005) 0.99
The protein fluorescence and structural toolkit: Database and programs for the analysis of protein fluorescence and structural data. Proteins (2008) 0.99
pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96
Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor. J Mol Biol (2005) 0.95
pHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J Control Release (2013) 0.95
Targeting breast tumors with pH (low) insertion peptides. Mol Pharm (2014) 0.94
Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A (2010) 0.92
Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry (2006) 0.92
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91
Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90
Folding kinetics and structure of OEP16. Biophys J (2004) 0.90
Topography studies on the membrane interaction mechanism of the eosinophil cationic protein. Biochemistry (2007) 0.90
The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology (2010) 0.89
Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A (2012) 0.87
Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta (2009) 0.87