Published in Proc Natl Acad Sci U S A on April 11, 2006
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature (2014) 2.70
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71
Unassisted translocation of large polypeptide domains across phospholipid bilayers. J Cell Biol (2006) 1.69
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50
Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids (2011) 1.45
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42
pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.38
Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29
Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29
Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem (2012) 1.23
pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19
pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi (2009) 1.16
Cationic shell-cross-linked knedel-like (cSCK) nanoparticles for highly efficient PNA delivery. Mol Pharm (2009) 1.15
Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10
Myristoyl-based transport of peptides into living cells. Biochemistry (2007) 1.09
In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol (2012) 1.09
Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07
The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango. Virology (2008) 1.07
Luminescent gold nanoparticles with pH-dependent membrane adsorption. J Am Chem Soc (2011) 1.04
Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol (2011) 1.02
Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00
pH-controlled delivery of luminescent europium coated nanoparticles into platelets. Proc Natl Acad Sci U S A (2012) 0.96
pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96
pHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J Control Release (2013) 0.95
Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94
pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain. Toxins (Basel) (2013) 0.93
Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun (2012) 0.93
Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano Lett (2012) 0.93
Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90
Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity. Angew Chem Int Ed Engl (2015) 0.89
Advanced targeted nanomedicine. J Biotechnol (2015) 0.87
Fluorescence imaging agents in cancerology. Radiol Oncol (2010) 0.87
Phospholipid conjugate for intracellular delivery of peptide nucleic acids. Bioconjug Chem (2009) 0.87
pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86
Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Mol Pharm (2015) 0.85
Stimuli-responsive nanoparticles for targeting the tumor microenvironment. J Control Release (2015) 0.85
Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer (2012) 0.83
Heterogeneous diffusion of a membrane-bound pHLIP peptide. Biophys J (2010) 0.83
Probe for the measurement of cell surface pH in vivo and ex vivo. Proc Natl Acad Sci U S A (2016) 0.82
The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A (2015) 0.81
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death. Biochem J (2015) 0.80
Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS Biomater Sci Eng (2016) 0.78
pHLIP Peptide Interaction with a Membrane Monitored by SAXS. J Phys Chem B (2016) 0.78
pHLIP and acidity as a universal biomarker for cancer. Yale J Biol Med (2012) 0.77
Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys (2014) 0.77
pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. Sci Rep (2016) 0.77
Membrane binding and insertion of a pHLIP peptide studied by all-atom molecular dynamics simulations. Int J Mol Sci (2013) 0.76
pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. Oncotarget (2015) 0.76
pH-Dependent Cellular Internalization of Paramagnetic Nanoparticle. ACS Sens (2016) 0.75
Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells & Mouse Models. Mol Pharm (2017) 0.75
Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance. Nat Commun (2015) 0.75
Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One (2014) 0.75
Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide. Chembiochem (2015) 0.75
Tumour acidosis: from the passenger to the driver's seat. Nat Rev Cancer (2017) 0.75
Insertion into lipid bilayer of truncated pHLIP(®)peptide. Biochem Biophys Rep (2016) 0.75
Synthesis and characterization of pHLIP(®) coated gold nanoparticles. Biochem Biophys Rep (2017) 0.75
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science (1991) 12.17
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72
Membrane protein folding and oligomerization: the two-stage model. Biochemistry (1990) 4.86
Fluorescence assay for phospholipid membrane asymmetry. Biochemistry (1991) 3.13
Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol (2005) 3.09
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc Natl Acad Sci U S A (1977) 2.77
Causes and consequences of tumour acidity and implications for treatment. Mol Med Today (2000) 2.44
Membrane protein folding: beyond the two stage model. FEBS Lett (2003) 2.20
Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry (1997) 2.11
Designing transmembrane alpha-helices that insert spontaneously. Biochemistry (2000) 1.73
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J (2000) 1.69
Transmembrane helices before, during, and after insertion. Curr Opin Struct Biol (2005) 1.64
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton. J Natl Cancer Inst (1995) 1.44
Recognition of chromosomal DNA by PNAs. Chem Biol (2004) 1.41
Acidosis potentiates oxidative neuronal death by multiple mechanisms. J Neurochem (1999) 1.33
Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys (2004) 1.31
Sec-independent translocation of a 100-residue periplasmic N-terminal tail in the E. coli inner membrane protein proW. EMBO J (1994) 1.21
A combined in vitro/bioinformatic investigation of redox regulatory mechanisms governing cell cycle progression. Physiol Genomics (2004) 1.17
Determining the membrane topology of proteins: insertion pathway of a transmembrane helix of annexin 12. Biochemistry (2002) 1.09
Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions? Atherosclerosis (1997) 1.06
Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers. Biochemistry (2002) 1.04
YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins. J Cell Biol (2004) 1.04
Sec-independent protein insertion into the inner E. coli membrane. A phenomenon in search of an explanation. FEBS Lett (1994) 1.01
Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates. Nucleic Acids Res (2004) 0.94
Liposomal delivery of antisense oligonucleotides for efficient downregulation of Bcl-2 and induction of apoptosis. Cancer Biother Radiopharm (2002) 0.92
The action of phalloidin. Curr Probl Clin Biochem (1977) 0.82
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A (2004) 2.44
Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol (2003) 2.32
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
Membrane protein folding: beyond the two stage model. FEBS Lett (2003) 2.20
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J (2007) 2.06
Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol (2002) 1.85
Protein dynamics studied by neutron scattering. Q Rev Biophys (2002) 1.81
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A (2008) 1.71
Normal modes for predicting protein motions: a comprehensive database assessment and associated Web tool. Protein Sci (2005) 1.51
Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J (2003) 1.51
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50
Protein area occupancy at the center of the red blood cell membrane. Proc Natl Acad Sci U S A (2008) 1.49
Dynamic helix interactions in transmembrane signaling. Cell (2006) 1.49
Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol (2002) 1.47
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A (2010) 1.42
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J Biol Chem (2003) 1.41
pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.38
Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol (2004) 1.32
Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys (2004) 1.31
Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29
Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J (2008) 1.29
Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function. Annu Rev Biochem (2006) 1.27
An integrated system for studying residue coevolution in proteins. Bioinformatics (2007) 1.25
Bacteriorhodopsin/amphipol complexes: structural and functional properties. Biophys J (2008) 1.24
GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J Biol Chem (2002) 1.23
Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem (2012) 1.23
pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A (2012) 1.19
Computational analysis of membrane proteins: the largest class of drug targets. Drug Discov Today (2009) 1.19
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem (2004) 1.16
pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi (2009) 1.16
Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families. Genome Res (2010) 1.13
Tuning the insertion properties of pHLIP. Biochim Biophys Acta (2009) 1.10
Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices. Biophys J (2004) 1.10
Mutational analysis of synaptobrevin transmembrane domain oligomerization. Biochemistry (2002) 1.09
In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol (2012) 1.09
Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol (2004) 1.08
Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci (2009) 1.07
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism. Proc Natl Acad Sci U S A (2004) 1.06
The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol (2006) 1.04
Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol (2003) 1.02
Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol (2011) 1.02
Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J (2012) 1.01
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry (2011) 1.00
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. FASEB J (2011) 1.00
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett (2005) 0.99
pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A (2012) 0.96
pHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J Control Release (2013) 0.95
Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor. J Mol Biol (2005) 0.95
Targeting breast tumors with pH (low) insertion peptides. Mol Pharm (2014) 0.94
Antiproliferative effect of pHLIP-amanitin. Biochemistry (2013) 0.94
Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry (2006) 0.92
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A (2010) 0.92
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91
Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry (2013) 0.90
The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology (2010) 0.89
Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta (2009) 0.87
Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A (2012) 0.87
pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86
Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. J Virol (2013) 0.83
Thermostability of membrane protein helix-helix interaction elucidated by statistical analysis. FEBS Lett (2002) 0.82
Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng (2002) 0.81
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Helix Interaction Tool (HIT): a web-based tool for analysis of helix-helix interactions in proteins. Bioinformatics (2006) 0.80
Hydration dependence of active core fluctuations in bacteriorhodopsin. Biophys J (2008) 0.79
Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments. Anal Bioanal Chem (2009) 0.75
Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin. Biochem Biophys Res Commun (2012) 0.75
Applications of pHLIP Technology for Cancer Imaging and Therapy: (Trends in Biotechnology 35, 653-664, 2017). Trends Biotechnol (2017) 0.75