PubRank

Efstathios S Gonos

Author PubWeight™ 53.56‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol 2002 1.70
2 The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell 2013 1.56
3 Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res 2004 1.55
4 Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem 2003 1.51
5 Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem 2005 1.43
6 Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res 2006 1.40
7 Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012 1.35
8 Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell 2013 1.33
9 The genetics of human longevity. Ann N Y Acad Sci 2006 1.30
10 Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. Int J Cancer 2007 1.27
11 Proteasome dysfunction in mammalian aging: steps and factors involved. Exp Gerontol 2005 1.27
12 Advances and challenges in basic and translational research on clusterin. Cancer Res 2009 1.20
13 Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res 2009 1.16
14 Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 2010 1.16
15 Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp Gerontol 2002 1.09
16 What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev 2005 1.03
17 Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free Radic Biol Med 2005 1.01
18 The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res 2007 1.01
19 What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol 2002 0.97
20 Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide. Cell Stress Chaperones 2002 0.96
21 Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res 2002 0.95
22 Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech Ageing Dev 2005 0.95
23 Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Biogerontology 2004 0.92
24 Anti-ageing and rejuvenating effects of quercetin. Exp Gerontol 2010 0.91
25 Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals. Adv Cancer Res 2009 0.89
26 Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence. Exp Gerontol 2007 0.89
27 The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem 2009 0.87
28 Proteasome response to interferon-gamma is altered in senescent human fibroblasts. FEBS Lett 2006 0.87
29 CHIP-dependent p53 regulation occurs specifically during cellular senescence. Free Radic Biol Med 2010 0.87
30 Cloning of differentially expressed genes in skin fibroblasts from centenarians. Biogerontology 2004 0.87
31 Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems. Biogerontology 2002 0.87
32 Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts. Anticancer Res 2006 0.86
33 Proteasome activation as a novel antiaging strategy. IUBMB Life 2008 0.86
34 Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Ann N Y Acad Sci 2004 0.85
35 Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. FEBS J 2009 0.84
36 Proteasome function determines cellular homeostasis and the rate of aging. Adv Exp Med Biol 2010 0.84
37 Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell 2008 0.83
38 Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells. Biogerontology 2006 0.82
39 A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Gene 2004 0.82
40 CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins. Mech Ageing Dev 2011 0.82
41 Exposure of human diploid fibroblasts to hypoxia extends proliferative life span. Ann N Y Acad Sci 2007 0.82
42 CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem 2011 0.81
43 Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. Ann N Y Acad Sci 2006 0.81
44 Structure and function of the ubiquitin-proteasome system: modulation of components. Prog Mol Biol Transl Sci 2012 0.80
45 Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. Arch Biochem Biophys 2005 0.80
46 Alterations of senescence biomarkers in human cells by exposure to CrVI in vivo and in vitro. Exp Gerontol 2004 0.79
47 Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J/Clusterin in welders. Bioinorg Chem Appl 2008 0.79
48 Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways. Free Radic Biol Med 2009 0.79
49 Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine. Cell Res 2004 0.78
50 The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life 2012 0.78
51 High-resolution quantitative metabolome analysis of urine by automated flow injection NMR. Anal Chem 2013 0.78
52 Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study. Ann N Y Acad Sci 2007 0.77
53 Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. Cancer Genet Cytogenet 2010 0.77
54 Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface. Mech Ageing Dev 2014 0.76
55 Cloning approaches for identifying aging and longevity-related genes in mammals. ScientificWorldJournal 2002 0.75