Published in J Immunol on February 01, 2005
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun (2010) 3.89
Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog (2008) 2.86
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog (2009) 2.31
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe (2008) 1.98
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog (2007) 1.93
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J (2008) 1.76
Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways. J Immunol (2008) 1.64
TBK1 protects vacuolar integrity during intracellular bacterial infection. PLoS Pathog (2007) 1.43
Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol (2008) 1.25
Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll-like receptor-2-dependent mechanism. Immunology (2010) 1.15
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J (2012) 1.14
Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One (2011) 1.12
Innate sensors of microbial infection. J Clin Immunol (2005) 1.05
Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability. Infect Immun (2012) 0.99
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Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner. Infect Immun (2009) 0.93
Both TLR2 and TRIF contribute to interferon-β production during Listeria infection. PLoS One (2012) 0.92
LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation. J Biol Chem (2010) 0.92
Bifidobacterium bifidum actively changes the gene expression profile induced by Lactobacillus acidophilus in murine dendritic cells. PLoS One (2010) 0.92
Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress. J Bacteriol (2013) 0.91
Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol (2014) 0.91
Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection. PLoS Genet (2007) 0.90
The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol Rev (2014) 0.89
KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity. J Clin Invest (2008) 0.88
Innate immune recognition and inflammasome activation in listeria monocytogenes infection. Front Microbiol (2011) 0.86
Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection. Front Cell Infect Microbiol (2014) 0.85
The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol (2014) 0.81
RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli. Sci Rep (2015) 0.81
The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons. Front Cell Infect Microbiol (2014) 0.80
Therapeutic targeting of NOD1 receptors. Br J Pharmacol (2013) 0.79
The human P-glycoprotein transporter enhances the type I interferon response to Listeria monocytogenes infection. Infect Immun (2015) 0.78
The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway. J Immunol (2017) 0.75
Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med (2004) 4.34
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell (2004) 4.20
Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
Human rabies prevention--United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep (2008) 3.58
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol (2004) 3.27
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J (2006) 3.13
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell (2003) 2.99
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest (2009) 2.96
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med (2004) 2.80
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest (2008) 2.66
The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev (2003) 2.66
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol (2004) 2.52
Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology (2013) 2.45
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science (2013) 2.34
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol (2007) 2.32
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest (2006) 2.29
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm. Proc Natl Acad Sci U S A (2008) 2.22
Systematic identification of type I and type II interferon-induced antiviral factors. Proc Natl Acad Sci U S A (2012) 2.18
Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med (2006) 2.17
NF-kappaB inhibits gammaherpesvirus lytic replication. J Virol (2003) 2.15
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One (2009) 2.14
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity (2012) 2.13
The host type I interferon response to viral and bacterial infections. Cell Res (2005) 2.12
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol (2012) 2.11
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal (2010) 2.05
Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci U S A (2008) 2.05
Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J Biol Chem (2007) 1.89
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol (2007) 1.87
Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol (2003) 1.76
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem (2006) 1.75
New developments in the induction and antiviral effectors of type I interferon. Curr Opin Immunol (2010) 1.67
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A (2013) 1.60
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog (2009) 1.58
Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe (2009) 1.55
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog (2012) 1.52
Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant (2005) 1.51
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity (2013) 1.49
Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. J Immunol (2004) 1.47
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A (2004) 1.39
Non-canonical NF-κB signaling activation and regulation: principles and perspectives. Immunol Rev (2011) 1.39
Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell (2010) 1.38
Negative regulation of NF-kappaB signaling by PIAS1. Mol Cell Biol (2005) 1.38
PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res (2008) 1.37
NF-κB and innate immunity. Curr Top Microbiol Immunol (2011) 1.34
Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma. Clin Cancer Res (2014) 1.33
Toll-like receptors and innate antiviral responses. Curr Opin Immunol (2003) 1.31
Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J Immunol (2010) 1.31
Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe (2009) 1.30
TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol (2006) 1.22
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res (2010) 1.21
From plankton to pathogen recognition. Nat Med (2004) 1.20
Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation (2008) 1.17
Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. Proc Natl Acad Sci U S A (2013) 1.17
Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol (2003) 1.16
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med (2012) 1.14
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A (2002) 1.13
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure (2002) 1.11
Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One (2011) 1.11
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology (2011) 1.09
TRAF3 and its biological function. Adv Exp Med Biol (2007) 1.06
Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression. Oncogene (2004) 1.06
TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections. J Immunol (2009) 1.04
PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway. PLoS One (2011) 1.03
A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. J Virol (2007) 1.02
LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol (2007) 1.01
Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria. PLoS One (2012) 1.00
The interferon response to bacterial and viral infections. J Endotoxin Res (2006) 1.00
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem (2003) 0.99
Cost effectiveness of rabies post exposure prophylaxis in the United States. Vaccine (2008) 0.97