Published in Am J Physiol Gastrointest Liver Physiol on January 20, 2005
Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal (2010) 1.91
ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol (2007) 1.33
Purinergic signalling and cancer. Purinergic Signal (2013) 1.18
Purinergic receptors and gastrointestinal secretomotor function. Purinergic Signal (2008) 1.03
The P2X(7) receptor and intracellular pathogens: a continuing struggle. Purinergic Signal (2009) 0.93
OppA, the ecto-ATPase of Mycoplasma hominis induces ATP release and cell death in HeLa cells. BMC Microbiol (2008) 0.93
Activation of P2X receptors induces apoptosis in human retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 0.91
Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis. Cancer Lett (2010) 0.84
Atypical P2X receptor pharmacology in two human osteoblast-like cell lines. Br J Pharmacol (2009) 0.84
P2X4 receptor regulation of transient receptor potential melastatin type 6 (TRPM6) Mg2+ channels. Pflugers Arch (2014) 0.83
Agonists and antagonists for P2 receptors. Novartis Found Symp (2006) 0.83
Reversible inhibition of Chlamydia trachomatis infection in epithelial cells due to stimulation of P2X(4) receptors. Infect Immun (2012) 0.81
P2 receptors in renal pathophysiology. Purinergic Signal (2009) 0.81
Opposing effects of P2X(7) and P2Y purine/pyrimidine-preferring receptors on proliferation of astrocytes induced by fibroblast growth factor-2: implications for CNS development, injury, and repair. J Neurosci Res (2008) 0.81
Role of ion channels in regulating Ca²⁺ homeostasis during the interplay between immune and cancer cells. Cell Death Dis (2015) 0.81
Extracellular nucleotides inhibit oxalate transport by human intestinal Caco-2-BBe cells through PKC-δ activation. Am J Physiol Cell Physiol (2013) 0.80
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev (2017) 0.80
P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy. Am J Physiol Gastrointest Liver Physiol (2014) 0.78
Purinergic receptor antagonism prevents cold preservation-induced cell death independent of cellular ATP levels. J Surg Res (2007) 0.78
Extracellular purines, purinergic receptors and tumor growth. Oncogene (2016) 0.76
H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway. Oncotarget (2015) 0.75
Important roles of P2Y receptors in the inflammation and cancer of digestive system. Oncotarget (2016) 0.75
Exogenous adenosine 5'-triphosphate does not improve survival in rats with acute liver failure. Dig Dis Sci (2007) 0.75
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33
Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci (2006) 3.17
Purinergic signalling in the nervous system: an overview. Trends Neurosci (2008) 2.86
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med (2004) 2.59
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56
Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol (2003) 2.44
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci (2003) 2.37
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol (2005) 2.25
The oral microbiota: living with a permanent guest. DNA Cell Biol (2009) 2.19
Pharmacology of P2X channels. Pflugers Arch (2006) 2.14
P2 receptors in cardiovascular regulation and disease. Purinergic Signal (2007) 1.91
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One (2010) 1.85
P2 receptors and cancer. Trends Pharmacol Sci (2006) 1.80
Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun (2004) 1.75
Chlamydia and apoptosis: life and death decisions of an intracellular pathogen. Nat Rev Microbiol (2004) 1.63
Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells. Infect Immun (2006) 1.59
Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci (2003) 1.59
Chlamydia. Nat Rev Microbiol (2004) 1.49
Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol (2002) 1.45
Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol (2003) 1.44
Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell Microbiol (2006) 1.44
A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice. Eur J Immunol (2004) 1.43
Purinergic signalling and bone remodelling. Curr Opin Pharmacol (2010) 1.43
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. J Biol Chem (2009) 1.37
Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival. PLoS Pathog (2006) 1.36
P2X receptors and their role in female idiopathic detrusor instability. J Urol (2002) 1.36
Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. MBio (2011) 1.36
Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol (2005) 1.35
ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol (2007) 1.33
Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. Endocrinology (2007) 1.32
Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease. J Cell Biol (2008) 1.32
The double life of ATP. Sci Am (2009) 1.31
Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. J Biol Chem (2010) 1.31
Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity (2003) 1.31
Osteoblast responses to nucleotides increase during differentiation. Bone (2006) 1.30
ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell Microbiol (2009) 1.29
Purinergic signaling along the renal tubule: the current state of play. News Physiol Sci (2003) 1.29
Localisation of P2Y1 and P2Y4 receptors in dorsal root, nodose and trigeminal ganglia of the rat. Histochem Cell Biol (2003) 1.27
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One (2011) 1.25
ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells. J Cell Biol (2002) 1.24
Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology (2003) 1.24
Regulation of bone resorption and formation by purines and pyrimidines. Trends Pharmacol Sci (2003) 1.23
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. J Exp Med (2011) 1.22
Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol (2004) 1.21
Purinergic signalling and cancer. Purinergic Signal (2013) 1.18
Hypoxia stimulates vesicular ATP release from rat osteoblasts. J Cell Physiol (2009) 1.18
Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X Receptors. Drug Dev Res (2000) 1.16
Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol (2003) 1.16
Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Infect Immun (2002) 1.15
Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma. EMBO Mol Med (2012) 1.14
Alarmins, inflammasomes and immunity. Biomed J (2013) 1.13
At the innate frontiers between mother and fetus: linking abortion with complement activation. Immunity (2003) 1.12
Purinoceptors on neuroglia. Mol Neurobiol (2009) 1.11
An evolutionary history of P2X receptors. Purinergic Signal (2008) 1.11
Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. J Invest Dermatol (2003) 1.11
Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem (2002) 1.10
Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator. J Biol Chem (2002) 1.10
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem (2005) 1.10
P2 receptor web: complexity and fine-tuning. Pharmacol Ther (2006) 1.09
Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways. PLoS One (2012) 1.09
Purinergic signalling in autonomic control. Trends Neurosci (2009) 1.08
P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 1.08
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08
Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai. BMC Microbiol (2009) 1.07
Microglia: proliferation and activation driven by the P2X7 receptor. Int J Biochem Cell Biol (2010) 1.07
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol (2010) 1.07
Involvement of purinergic signaling in cardiovascular diseases. Drug News Perspect (2003) 1.07
Neurochemical identification of enteric neurons expressing P2X(3) receptors in the guinea-pig ileum. Histochem Cell Biol (2002) 1.06
Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Dev Dyn (2003) 1.05
Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice. J Immunol (2007) 1.05
Pathophysiology of astroglial purinergic signalling. Purinergic Signal (2012) 1.03
Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models. Kidney Int (2004) 1.03
Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem Pharmacol (2005) 1.03
Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites. Microbes Infect (2012) 1.01
Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis. J Invest Dermatol (2003) 1.00
P2X2 and P2X3 purinoceptors in the rat enteric nervous system. Histochem Cell Biol (2004) 1.00
Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol (2013) 1.00
Expression of P2X receptors on rat microglial cells during early development. Glia (2005) 0.99
Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther (2002) 0.99
Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways. Infect Immun (2008) 0.97
ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. J Cell Biochem (2002) 0.97
Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice. PLoS One (2012) 0.96
Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair. Stem Cell Rev (2012) 0.96
Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. Drug Dev Res (1998) 0.96
Spinal P2X(7) receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model. Behav Brain Res (2011) 0.96
Development of nerves expressing P2X3 receptors in the myenteric plexus of rat stomach. Histochem Cell Biol (2004) 0.95
P2Y purinergic receptors regulate the growth of human melanomas. Cancer Lett (2004) 0.95
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. PLoS One (2008) 0.95
Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One (2012) 0.95
Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases. Int J Urol (2008) 0.95
Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion. Pain (2008) 0.95
The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors. Bone (2012) 0.94
Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein. BMC Microbiol (2008) 0.94