Pharmacology of P2X channels.

Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature (2012) 2.53

Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) (2009) 2.25

Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev (2011) 2.14

Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease. Infect Immun (2011) 1.99

Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol (2007) 1.77

New structure enlivens interest in P2X receptors. Trends Pharmacol Sci (2010) 1.66

An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature (2007) 1.66

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J (2009) 1.61

Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats. Clin Sci (Lond) (2009) 1.47

P2X receptors as drug targets. Mol Pharmacol (2012) 1.43

Purinergic mechanosensory transduction and visceral pain. Mol Pain (2009) 1.36

Molecular and functional properties of P2X receptors--recent progress and persisting challenges. Purinergic Signal (2012) 1.31

Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2009) 1.28

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci (2008) 1.23

Permeation properties of a P2X receptor in the green algae Ostreococcus tauri. J Biol Chem (2008) 1.22

Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol (2007) 1.20

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia. J Neurochem (2011) 1.10

Physiological mechanisms for the modulation of pannexin 1 channel activity. J Physiol (2012) 1.07

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol (2010) 1.07

Unresolved issues and controversies in purinergic signalling. J Physiol (2008) 1.03

P2X1 and P2X4 receptor currents in mouse macrophages. Br J Pharmacol (2007) 1.02

Purinergic signalling in the urinary tract in health and disease. Purinergic Signal (2013) 1.01

ATP-mediated potassium recycling in the cochlear supporting cells. Purinergic Signal (2010) 1.01

Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs. Histochem Cell Biol (2008) 0.99

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chem Rev (2013) 0.98

Purinergic signalling in the gastrointestinal tract and related organs in health and disease. Purinergic Signal (2013) 0.95

Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys. Am J Physiol Renal Physiol (2013) 0.94

Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells. Mol Neurodegener (2010) 0.94

Introduction and perspective, historical note. Front Cell Neurosci (2013) 0.93

P2X receptor antagonists for pain management: examination of binding and physicochemical properties. Purinergic Signal (2011) 0.93

Opposite effects of zinc on human and rat P2X2 receptors. J Neurosci (2008) 0.92

Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice. J Physiol (2015) 0.92

Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice. Pain (2009) 0.91

Heteromeric assembly of P2X subunits. Front Cell Neurosci (2013) 0.90

The structural basis of ATP as an allosteric modulator. PLoS Comput Biol (2014) 0.90

Novel P2X7 receptor antagonists ease the pain. Br J Pharmacol (2007) 0.89

Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. J Biol Chem (2011) 0.89

Immunosuppression preserves renal autoregulatory function and microvascular P2X(1) receptor reactivity in ANG II-hypertensive rats. Am J Physiol Renal Physiol (2012) 0.89

Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors. Am J Physiol Regul Integr Comp Physiol (2009) 0.89

Novel identified receptors on mast cells. Front Immunol (2012) 0.88

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS One (2012) 0.88

IL-6 downregulates transcription of NTPDase2 via specific promoter elements. Am J Physiol Gastrointest Liver Physiol (2008) 0.88

Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency. Am J Physiol Heart Circ Physiol (2013) 0.87

P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex. J Appl Physiol (1985) (2010) 0.86

Interaction of P2 purinergic receptors with cellular macromolecules. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.86

The amyloid beta ion channel hypothesis of Alzheimer's disease. Neuropsychiatr Dis Treat (2007) 0.86

Using antibodies against P2Y and P2X receptors in purinergic signaling research. Purinergic Signal (2011) 0.86

Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization. Am J Physiol Gastrointest Liver Physiol (2013) 0.86

Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. Br J Pharmacol (2009) 0.86

Measuring ion channels on solid supported membranes. Biophys J (2009) 0.86

Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord. J Neurosci (2010) 0.85

Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating. J Physiol (2009) 0.85

Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res (2009) 0.84

Atypical P2X receptor pharmacology in two human osteoblast-like cell lines. Br J Pharmacol (2009) 0.84

P2 receptor-mediated modulation of neurotransmitter release-an update. Purinergic Signal (2007) 0.84

Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology (2015) 0.83

Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Purinergic Signal (2011) 0.83

Tonotopic action potential tuning of maturing auditory neurons through endogenous ATP. J Physiol (2016) 0.83

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC. Purinergic Signal (2012) 0.83

Purinergic signalling mobilizes mitochondrial Ca²⁺ in mouse Sertoli cells. J Physiol (2011) 0.82

ATP release from the human ureter on distension and P2X(3) receptor expression on suburothelial sensory nerves. Purinergic Signal (2008) 0.82

ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res (2008) 0.82

Inhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression. Mol Cell Biochem (2009) 0.81

P2X receptors are differentially expressed on vasopressin- and oxytocin-containing neurons in the supraoptic and paraventricular nuclei of rat hypothalamus. Histochem Cell Biol (2008) 0.81

P2X receptors as targets for the treatment of status epilepticus. Front Cell Neurosci (2013) 0.81

P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity. Eur J Neurosci (2008) 0.81

Lack of evidence for direct phosphorylation of recombinantly expressed P2X(2) and P2X (3) receptors by protein kinase C. Purinergic Signal (2007) 0.80

Alterations in vasoconstrictor responses to the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in DOCA-salt hypertensive rats. Pharmacol Res (2011) 0.80

Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors. Pharmaceuticals (Basel) (2013) 0.80

Amitriptyline does not block the action of ATP at human P2X4 receptor. Br J Pharmacol (2010) 0.80

Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors. BMC Neurosci (2011) 0.79

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres. J Physiol (2012) 0.79

Correlation between P2X7 receptor gene polymorphisms and gout. Rheumatol Int (2015) 0.78

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems. Purinergic Signal (2015) 0.78

Role of purinergic P2X receptors in the control of liver homeostasis. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.78

Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles. Purinergic Signal (2010) 0.78

Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex. Br J Pharmacol (2011) 0.78

Purinergic receptors are part of a signalling system for proliferation and differentiation in distinct cell lineages in human anagen hair follicles. Purinergic Signal (2008) 0.77

Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway. Pflugers Arch (2013) 0.77

The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signal (2009) 0.77

Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells. Purinergic Signal (2015) 0.77

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion. Purinergic Signal (2016) 0.76

P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1. Purinergic Signal (2013) 0.76

Extracellular ATP induces fast and transient non-selective cationic currents and cytosolic Ca2+ changes in human umbilical artery smooth muscle cells. Purinergic Signal (2011) 0.75

A fluorescent approach for identifying P2X1 ligands. Neuropharmacology (2015) 0.75

Structural insights into the nucleotide base specificity of P2X receptors. Sci Rep (2017) 0.75

Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage. J Cereb Blood Flow Metab (2015) 0.75

P2X3 and P2X2/3 Receptors Play a Crucial Role in Articular Hyperalgesia Development Through Inflammatory Mechanisms in the Knee Joint Experimental Synovitis. Mol Neurobiol (2016) 0.75

Some aspects of purinergic signaling in the ventricular system of porcine brain. Acta Vet Scand (2011) 0.75

Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain. Mol Pain (2016) 0.75

Novel channel-mediated choline transport in cholinergic neurons of the mouse retina. J Neurophysiol (2017) 0.75

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol (1929) 23.79

Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92

Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61

Purinergic nerves. Pharmacol Rev (1972) 12.05

Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol (1985) 9.20

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science (1996) 7.10

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (2003) 6.04

Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem (2001) 5.74

A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature (1994) 5.43

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature (1995) 5.38

Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32

A P2X purinoceptor expressed by a subset of sensory neurons. Nature (1995) 4.86

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (1994) 4.61

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature (2000) 4.53

Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. Br J Pharmacol (1988) 4.52

ATP signaling is crucial for communication from taste buds to gustatory nerves. Science (2005) 4.13

Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther (1994) 3.93

Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood (2001) 3.84

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci (1996) 3.71

The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol (1982) 3.52

Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol (2004) 3.43

ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes--a possible sensory mechanism? J Physiol (1997) 3.43

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain (2005) 3.37

The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (1959) 3.36

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev (2001) 3.26

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J (1998) 3.23

Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol (1972) 2.93

Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Nature (2000) 2.85

Pore dilation of neuronal P2X receptor channels. Nat Neurosci (1999) 2.81

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol (1997) 2.81

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem (1997) 2.78

P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med (2004) 2.78

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature (2000) 2.73

Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol (2002) 2.71

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci (1999) 2.63

Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol (1978) 2.61

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors). Mol Pharmacol (1995) 2.50

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem (1993) 2.50

An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J (1996) 2.48

Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol (2000) 2.47

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur J Pharmacol (1992) 2.43

P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci (2001) 2.41

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature (1997) 2.33

Are second messengers crucial for opening the pore associated with P2X7 receptor? Am J Physiol Cell Physiol (2004) 2.32

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol (2005) 2.25

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A (2002) 2.24

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor. Neuropharmacology (1997) 2.24

Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci (2001) 2.17

ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem (2000) 2.16

Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder. J Physiol (1988) 2.10

Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci (1999) 2.10

Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J Biol Chem (2000) 2.08

Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius. J Neurosci (2004) 2.08

Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol (1996) 2.07

A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett (1995) 1.99

P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci U S A (1996) 1.98

Distinct Localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci (2001) 1.97

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology (1997) 1.96

siRNA relieves chronic neuropathic pain. Nucleic Acids Res (2004) 1.96

Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol (1999) 1.95

Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues. Mol Pharmacol (1998) 1.94

P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci (2003) 1.94

Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J Anat (1999) 1.94

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol (2003) 1.93

Subunit arrangement in P2X receptors. J Neurosci (2003) 1.93

The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci (1998) 1.92

P2X receptors in peripheral neurons. Prog Neurobiol (2001) 1.91

Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol (1998) 1.91

Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. J Biol Chem (1999) 1.90

Tissue distribution of the P2X7 receptor. Neuropharmacology (1997) 1.90

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem (2003) 1.87

Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci U S A (1996) 1.86

P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci (1998) 1.85

ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol (2002) 1.84

Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J Biol Chem (2005) 1.84

Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli. J Pharmacol Exp Ther (1975) 1.82

The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem (2005) 1.81

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol (1998) 1.78

Characterization of P2x-receptors in rabbit isolated ear artery. Br J Pharmacol (1990) 1.76

The role of positively charged amino acids in ATP recognition by human P2X(1) receptors. J Biol Chem (2000) 1.74

The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol (1990) 1.74

The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest (1995) 1.73

N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptors. Am J Physiol Cell Physiol (2005) 1.72

Reanalysis of P2X7 receptor expression in rodent brain. J Neurosci (2004) 1.64

Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol (2000) 1.64

Mapping of the benzodiazepine recognition site on GABA(A) receptors. Curr Top Med Chem (2002) 1.61

P2X receptor trafficking in neurons is subunit specific. J Neurosci (2002) 1.60

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci (2003) 1.59

ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest (2005) 1.58

Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH. Br J Pharmacol (1996) 1.57

Distribution of the P2X2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol (1999) 1.57

Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol (2004) 1.57

Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. Br J Pharmacol (1997) 1.57

A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med (2003) 1.56

Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. J Neurophysiol (1997) 1.54

Ionic effects on human recombinant P2X7 receptor function. Naunyn Schmiedebergs Arch Pharmacol (1999) 1.52

Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor. J Neurosci (1998) 1.52

Dual sensory innervation of pulmonary neuroepithelial bodies. Am J Respir Cell Mol Biol (2003) 1.52

ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists. J Biol Chem (2003) 1.50

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28

Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci (2006) 3.17

Purinergic signalling in the nervous system: an overview. Trends Neurosci (2008) 2.86

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med (2004) 2.59

Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci (2003) 2.37

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol (2005) 2.25

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function. Am J Physiol Regul Integr Comp Physiol (2009) 2.11

P2 receptors in cardiovascular regulation and disease. Purinergic Signal (2007) 1.91

P2 receptors and cancer. Trends Pharmacol Sci (2006) 1.80

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci (2003) 1.59

ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest (2005) 1.58

Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol (2002) 1.45

Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol (2003) 1.44

Purinergic signalling and bone remodelling. Curr Opin Pharmacol (2010) 1.43

P2X receptors and their role in female idiopathic detrusor instability. J Urol (2002) 1.36

Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. Endocrinology (2007) 1.32

The double life of ATP. Sci Am (2009) 1.31

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity (2003) 1.31

Osteoblast responses to nucleotides increase during differentiation. Bone (2006) 1.30

Purinergic signaling along the renal tubule: the current state of play. News Physiol Sci (2003) 1.29

Localisation of P2Y1 and P2Y4 receptors in dorsal root, nodose and trigeminal ganglia of the rat. Histochem Cell Biol (2003) 1.27

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol (2004) 1.26

Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology (2003) 1.24

ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells. J Cell Biol (2002) 1.24

Regulation of bone resorption and formation by purines and pyrimidines. Trends Pharmacol Sci (2003) 1.23

Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol (2004) 1.21

Purinergic signalling and cancer. Purinergic Signal (2013) 1.18

Hypoxia stimulates vesicular ATP release from rat osteoblasts. J Cell Physiol (2009) 1.18

Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X Receptors. Drug Dev Res (2000) 1.16

Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol (2003) 1.16

Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit. J Physiol (2003) 1.13

Purinoceptors on neuroglia. Mol Neurobiol (2009) 1.11

An evolutionary history of P2X receptors. Purinergic Signal (2008) 1.11

Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. J Invest Dermatol (2003) 1.11

ATP modulation of excitatory synapses onto interneurons. J Neurosci (2003) 1.10

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol (2003) 1.10

P2 receptor web: complexity and fine-tuning. Pharmacol Ther (2006) 1.09

Purinergic signalling in autonomic control. Trends Neurosci (2009) 1.08

RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol (2006) 1.08

P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 1.08

Microglia: proliferation and activation driven by the P2X7 receptor. Int J Biochem Cell Biol (2010) 1.07

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol (2010) 1.07

Involvement of purinergic signaling in cardiovascular diseases. Drug News Perspect (2003) 1.07

Neurochemical identification of enteric neurons expressing P2X(3) receptors in the guinea-pig ileum. Histochem Cell Biol (2002) 1.06

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain (2010) 1.06

Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Dev Dyn (2003) 1.05

Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models. Kidney Int (2004) 1.03

Pathophysiology of astroglial purinergic signalling. Purinergic Signal (2012) 1.03

ATP and P2X purinoceptors in urinary tract disorders. Handb Exp Pharmacol (2011) 1.03

Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol (2006) 1.03

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem Pharmacol (2005) 1.03

ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A (2013) 1.02

Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain (2005) 1.02

Expression and function of rat urothelial P2Y receptors. Am J Physiol Renal Physiol (2008) 1.01

Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis. J Invest Dermatol (2003) 1.00

P2X2 and P2X3 purinoceptors in the rat enteric nervous system. Histochem Cell Biol (2004) 1.00

Expression of P2X receptors on rat microglial cells during early development. Glia (2005) 0.99

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther (2002) 0.99

Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci (2004) 0.97

P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol (2005) 0.97

ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. J Cell Biochem (2002) 0.97

Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair. Stem Cell Rev (2012) 0.96

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. Drug Dev Res (1998) 0.96

Spinal P2X(7) receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model. Behav Brain Res (2011) 0.96

Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases. Int J Urol (2008) 0.95

Development of nerves expressing P2X3 receptors in the myenteric plexus of rat stomach. Histochem Cell Biol (2004) 0.95

P2Y purinergic receptors regulate the growth of human melanomas. Cancer Lett (2004) 0.95

Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion. Pain (2008) 0.95

The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors. Bone (2012) 0.94

Localization of P2X3 receptors and coexpression with P2X2 receptors during rat embryonic neurogenesis. J Comp Neurol (2002) 0.94

Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol (2004) 0.93

The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Trends Pharmacol Sci (2005) 0.93

Tissue distribution of P2X4 receptors studied with an ectodomain antibody. Cell Tissue Res (2003) 0.91

The purinergic component of human vas deferens contraction. Fertil Steril (2006) 0.91

Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures. FASEB J (2004) 0.91

Developing Core Sets for persons following amputation based on the International Classification of Functioning, Disability and Health as a way to specify functioning. Prosthet Orthot Int (2009) 0.91

Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract. Histochem Cell Biol (2009) 0.91

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett (2009) 0.90

Changes in expression of P2X purinoceptors in rat cerebellum during postnatal development. Brain Res Dev Brain Res (2005) 0.90

Changes in P2X3 purinoceptors in sensory ganglia of the mouse during embryonic and postnatal development. Histochem Cell Biol (2004) 0.90

P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats. Mol Cell Endocrinol (2003) 0.89

The distribution of P2X5 purinergic receptors in the enteric nervous system of mouse. Cell Tissue Res (2004) 0.89

P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp Nephrol (2002) 0.89

Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo. BJU Int (2008) 0.88