The P2X(7) receptor and intracellular pathogens: a continuing struggle.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 2686820)

Published in Purinergic Signal on February 12, 2009

Authors

Robson Coutinho-Silva1, Gladys Corrêa, Ali Abdul Sater, David M Ojcius

Author Affiliations

1: Immunobiology Program, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, 21941-902, RJ, Brazil, rcsilva@biof.ufrj.br.

Articles citing this

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites. Microbes Infect (2012) 1.01

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol (2013) 1.00

Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J Biol Chem (2013) 0.95

Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury. J Gen Physiol (2010) 0.95

Purinergic signalling and immune cells. Purinergic Signal (2014) 0.94

P2 receptors and immunity. Microbes Infect (2012) 0.93

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun (2016) 0.93

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal (2013) 0.92

In Mycoplasma hominis the OppA-mediated cytoadhesion depends on its ATPase activity. BMC Microbiol (2011) 0.89

Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Sci Rep (2013) 0.88

Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. Pflugers Arch (2014) 0.86

Differential modulation of ATP-induced P2X7-associated permeabilities to cations and anions of macrophages by infection with Leishmania amazonensis. PLoS One (2011) 0.83

Endothelial P2X7 receptors' expression is reduced by schistosomiasis. Purinergic Signal (2012) 0.79

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view. Purinergic Signal (2011) 0.79

The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontol 2000 (2015) 0.78

Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization. Biomolecules (2015) 0.77

Damage/Danger Associated Molecular Patterns (DAMPs) Modulate Chlamydia pecorum and C. trachomatis Serovar E Inclusion Development In Vitro. PLoS One (2015) 0.77

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One (2015) 0.75

Articles cited by this

Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99

A DNA polymorphism discovery resource for research on human genetic variation. Genome Res (1998) 7.44

The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 6.81

Lysosomes: fusion and function. Nat Rev Mol Cell Biol (2007) 5.74

A matter of life and cell death. Science (1998) 5.33

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin. J Exp Med (1994) 3.94

Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. Cell (2006) 3.83

Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci (2007) 3.01

Manipulation of host-cell pathways by bacterial pathogens. Nature (2007) 2.89

ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity (1997) 2.39

Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways. Exp Parasitol (1999) 2.17

Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J Immunol (1994) 2.12

Redox signaling: hydrogen peroxide as intracellular messenger. Exp Mol Med (1999) 2.09

Evasion of innate immunity by parasitic protozoa. Nat Immunol (2002) 2.08

Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia. Lancet (2002) 1.97

NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection. Proc Natl Acad Sci U S A (1998) 1.92

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol (2006) 1.87

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem (2003) 1.87

A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem (2001) 1.77

Intracellular survival by Chlamydia. Cell Microbiol (2000) 1.74

Mycobacterium tuberculosis phagosome. Mol Microbiol (1999) 1.71

Chlamydia and apoptosis: life and death decisions of an intracellular pathogen. Nat Rev Microbiol (2004) 1.63

Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J Cell Biol (1997) 1.48

A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Lancet (2002) 1.48

A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol (2005) 1.47

A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. J Biol Chem (2005) 1.47

Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes. J Immunol (2004) 1.40

ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D. J Immunol (2000) 1.38

A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol (2003) 1.36

Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage. J Biol Chem (2008) 1.36

Intracellular survival of Burkholderia cenocepacia in macrophages is associated with a delay in the maturation of bacteria-containing vacuoles. Cell Microbiol (2006) 1.35

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol (2007) 1.33

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity (2003) 1.31

Hijacking of eukaryotic functions by intracellular bacterial pathogens. Int Microbiol (2004) 1.30

HGF/MET signalling protects Plasmodium-infected host cells from apoptosis. Cell Microbiol (2005) 1.28

Inhibition of apoptosis by intracellular protozoan parasites. Int J Parasitol (2001) 1.23

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor. J Biol Chem (2004) 1.23

Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis (2002) 1.23

Secretion of ATP-utilizing enzymes, nucleoside diphosphate kinase and ATPase, by Mycobacterium bovis BCG: sequestration of ATP from macrophage P2Z receptors? Mol Microbiol (1999) 1.22

Modulation of P2Z/P2X(7) receptor activity in macrophages infected with Chlamydia psittaci. Am J Physiol Cell Physiol (2001) 1.20

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 1.20

ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guérin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes. J Immunol (2001) 1.20

Quaternary structure of nucleoside diphosphate kinases. J Bioenerg Biomembr (2000) 1.20

Toxoplasma gondii: perfecting an intracellular life style. Traffic (2003) 1.19

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science (2002) 1.13

Genetic susceptibility to mycobacterial disease in humans. Immunol Cell Biol (2006) 1.13

Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite-host interactions. Trends Parasitol (2001) 1.12

Sabotage and exploitation in macrophages parasitized by intracellular protozoans. Trends Parasitol (2005) 1.11

P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis. Clin Exp Immunol (2007) 1.11

P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophils. J Immunol (2001) 1.09

P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytes. Genes Immun (2004) 1.07

Roles of reactive oxygen species: signaling and regulation of cellular functions. Int Rev Cytol (1999) 1.06

Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice. J Immunol (2007) 1.05

Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med (2007) 1.05

Macrophage-mediated innate host defense against protozoan parasites. Crit Rev Microbiol (2002) 1.05

Apoptosis. Clues in the p53 murder mystery. Nature (1997) 1.05

Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. Blood (2000) 1.02

A Mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence. Arch Biochem Biophys (2001) 1.02

X-ray structure of Mycobacterium tuberculosis nucleoside diphosphate kinase. Proteins (2002) 1.01

Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages. J Infect Dis (2005) 1.00

Neospora caninum: tachyzoites express a potent type-I nucleoside triphosphate hydrolase. Exp Parasitol (1998) 0.98

P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production. FEBS Lett (2000) 0.98

P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol (2005) 0.97

Detection of nucleoside triphosphate hydrolase as a circulating antigen in sera of mice infected with Toxoplasma gondii. Infect Immun (1987) 0.97

A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population. FEBS Lett (2005) 0.96

Identification of Thr283 as a key determinant of P2X7 receptor function. Br J Pharmacol (2006) 0.95

Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Mol Biochem Parasitol (2007) 0.93

Host-Cell Survival and Death During Chlamydia Infection. Curr Immunol Rev (2007) 0.93

Role of lipid-mediated signal transduction in bacterial internalization. Cell Microbiol (2003) 0.91

The intracellular parasite Theileria parva protects infected T cells from apoptosis. Proc Natl Acad Sci U S A (1999) 0.90

Basis for substrate specificity of the Toxoplasma gondii nucleoside triphosphate hydrolase. Mol Biochem Parasitol (1998) 0.89

Nucleotide receptor signalling and the generation of reactive oxygen species. Purinergic Signal (2007) 0.89

The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Arthritis Res Ther (2005) 0.89

Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes. Diabetes (2004) 0.88

Mg-dependent ecto-ATPase activity in Leishmania tropica. Arch Biochem Biophys (1997) 0.87

A Mg-dependent ecto-ATPase is increased in the infective stages of Trypanosoma cruzi. Parasitol Res (2004) 0.87

Amino acid residues involved in autophosphorylation and phosphotransfer activities are distinct in nucleoside diphosphate kinase from Mycobacterium tuberculosis. J Biol Chem (2004) 0.87

Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia. Br J Haematol (2004) 0.86

Toxoplasma gondii inhibits apoptosis in infected cells by caspase inactivation and NF-kappaB activation. Yonsei Med J (2006) 0.86

The role of P2 receptors in controlling infections by intracellular pathogens. Purinergic Signal (2007) 0.84

Trypanosoma brucei brucei: biochemical characterization of ecto-nucleoside triphosphate diphosphohydrolase activities. Exp Parasitol (2006) 0.83

Entamoeba histolytica: localization and characterization of ca2+-dependent nucleotidases. Int J Parasitol (1981) 0.82

Trypanosoma cruzi does not induce apoptosis in murine fibroblasts. Parasitology (1999) 0.82

The nucleoside diphosphate kinase of Mycobacterium smegmatis: identification of proteins that modulate specificity of nucleoside triphosphate synthesis by the enzyme. Mol Microbiol (1997) 0.82

The relationship between nucleoside triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis. Microbes Infect (2003) 0.82

Trypanosoma rangeli: characterization of a Mg-dependent ecto ATP-diphosphohydrolase activity. Exp Parasitol (2005) 0.80

A calcium regulated adenosine triphosphatase in Entamoeba histolytica. Mol Biochem Parasitol (1981) 0.80

Survival of protozoan intracellular parasites in host cells. EMBO Rep (2004) 0.79

Functional P2X7 receptor polymorphisms (His155Tyr, Arg307Gln, Glu496Ala) in patients with Crohn's disease. Scand J Immunol (2007) 0.79

Production and characterization of a monoclonal antibody against nucleoside triphosphate hydrolase from Toxoplasma gondii. J Eukaryot Microbiol (2001) 0.78

Drug use and behavior change. Am J Public Health (1996) 0.76

Articles by these authors

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol (2003) 2.44

The oral microbiota: living with a permanent guest. DNA Cell Biol (2009) 2.19

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One (2010) 1.85

Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun (2004) 1.75

Chlamydia and apoptosis: life and death decisions of an intracellular pathogen. Nat Rev Microbiol (2004) 1.63

Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells. Infect Immun (2006) 1.59

Chlamydia. Nat Rev Microbiol (2004) 1.49

Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell Microbiol (2006) 1.44

A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice. Eur J Immunol (2004) 1.43

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. J Biol Chem (2009) 1.37

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival. PLoS Pathog (2006) 1.36

Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. MBio (2011) 1.36

Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol (2005) 1.35

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol (2007) 1.33

Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease. J Cell Biol (2008) 1.32

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity (2003) 1.31

Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. J Biol Chem (2010) 1.31

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell Microbiol (2009) 1.29

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One (2011) 1.25

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. J Exp Med (2011) 1.22

Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Infect Immun (2002) 1.15

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma. EMBO Mol Med (2012) 1.14

Alarmins, inflammasomes and immunity. Biomed J (2013) 1.13

At the innate frontiers between mother and fetus: linking abortion with complement activation. Immunity (2003) 1.12

Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem (2002) 1.10

Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator. J Biol Chem (2002) 1.10

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem (2005) 1.10

Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways. PLoS One (2012) 1.09

Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai. BMC Microbiol (2009) 1.07

Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice. J Immunol (2007) 1.05

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem Pharmacol (2005) 1.03

Host-cell lipid rafts: a safe door for micro-organisms? Biol Cell (2010) 1.02

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites. Microbes Infect (2012) 1.01

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol (2013) 1.00

P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol (2005) 0.97

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways. Infect Immun (2008) 0.97

Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. PLoS One (2008) 0.95

Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One (2012) 0.95

Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein. BMC Microbiol (2008) 0.94

The danger signal adenosine induces persistence of chlamydial infection through stimulation of A2b receptors. PLoS One (2009) 0.94

Host-Cell Survival and Death During Chlamydia Infection. Curr Immunol Rev (2007) 0.93

Correlation between infections with different genotypes of human cytomegalovirus and Epstein-Barr virus in subgingival samples and periodontal status of patients. J Clin Microbiol (2007) 0.93

The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif-dependent infection of cells and animals. Mol Microbiol (2012) 0.93

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. Biomed J (2014) 0.91

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. PLoS One (2013) 0.91

Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp. and characterization of their immunogenicity. Vaccine (2009) 0.90

Characterization of host cell death induced by Chlamydia trachomatis. Infect Immun (2006) 0.90

Cell death, BAX activation, and HMGB1 release during infection with Chlamydia. Microbes Infect (2004) 0.90

Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell Microbiol (2012) 0.90

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface. Reprod Biol Endocrinol (2003) 0.89

Cell death and inflammation during infection with the obligate intracellular pathogen, Chlamydia. Biochimie (2003) 0.89

Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain. Arch Microbiol (2007) 0.88

Chikungunya fever--re-emergence of an old disease. Microbes Infect (2009) 0.88

Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Sci Rep (2013) 0.88

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells. Biochim Biophys Acta (2009) 0.88

Retracted InvA protein is a Nudix hydrolase required for infection by pathogenic Leptospira in cell lines and animals. J Biol Chem (2011) 0.88

Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin. Innate Immun (2009) 0.87

The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages. PLoS One (2012) 0.87

Characterizing the presence and sensitivity of the P2X7 receptor in different compartments of the gut. J Innate Immun (2012) 0.86

Physicochemical and biological properties of biomimetic mineralo-protein nanoparticles formed spontaneously in biological fluids. Small (2012) 0.86

Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species. J Infect Dis (2013) 0.85

Serum-derived nanoparticles: de novo generation and growth in vitro, and internalization by mammalian cells in culture. Nanomedicine (Lond) (2011) 0.85

p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cell Microbiol (2013) 0.85

Methyl-accepting chemotaxis proteins 3 and 4 are responsible for Campylobacter jejuni chemotaxis and jejuna colonization in mice in response to sodium deoxycholate. J Med Microbiol (2014) 0.85

Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei. FEBS Lett (2004) 0.85

Identification of novel HLA-DR1-restricted epitopes from the hepatitis B virus envelope protein in mice expressing HLA-DR1 and vaccinated human subjects. Microbes Infect (2006) 0.85

Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines. Vaccine (2008) 0.84

The role of P2 receptors in controlling infections by intracellular pathogens. Purinergic Signal (2007) 0.84

Modulation of apoptosis during infection with Chlamydia. Methods Enzymol (2002) 0.83

Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development. J Infect Dis (2008) 0.83

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. Immunobiology (2010) 0.83

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids. J Biol Chem (2013) 0.83

Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis). Infect Immun (2002) 0.83

Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes. Mol Cell Proteomics (2012) 0.83

Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules. Int Immunol (2004) 0.82

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion. J Innate Immun (2014) 0.82

Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein. PLoS One (2012) 0.82

Reversible inhibition of Chlamydia trachomatis infection in epithelial cells due to stimulation of P2X(4) receptors. Infect Immun (2012) 0.81

The Th1 immune response against HIV-1 Gag p24-derived peptides in mice expressing HLA-A02.01 and HLA-DR1. Eur J Immunol (2007) 0.81

Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis. Cell Microbiol (2011) 0.81

An iterative strategy combining biophysical criteria and duration hidden Markov models for structural predictions of Chlamydia trachomatis sigma66 promoters. BMC Bioinformatics (2009) 0.81

Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans. Microbes Infect (2004) 0.80

Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. PLoS One (2013) 0.80

Rapid and sensitive identification of RNA from the emerging pathogen, coxsackievirus A6. Virol J (2012) 0.78

Absence of weight loss during Cryptosporidium infection in susceptible mice deficient in Fas-mediated apoptosis. Microbes Infect (2002) 0.78

Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells. J Biol Chem (2003) 0.78

Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. PLoS One (2011) 0.78

Microbes and Infection: past, present and future. Microbes Infect (2009) 0.78

Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity. Antimicrob Agents Chemother (2008) 0.78

Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun (2013) 0.77

Characterizing the intracellular distribution of metabolites in intact Chlamydia-infected cells by Raman and two-photon microscopy. Microbes Infect (2013) 0.77

CD1d-restricted NKT cells modulate placental and uterine leukocyte populations during chlamydial infection in mice. Microbes Infect (2013) 0.77

Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells. PLoS One (2012) 0.77

Is the hoopla over CPAF justified? Pathog Dis (2014) 0.77