Published in N Engl J Med on January 24, 2005
Host Genetic Susceptibility to Avian Influenza A/H5N1 | NCT01074736
Airborne transmission of influenza A/H5N1 virus between ferrets. Science (2012) 13.48
Evolution of H5N1 avian influenza viruses in Asia. Emerg Infect Dis (2005) 6.99
Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38
Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model. Proc Natl Acad Sci U S A (2006) 6.35
The pathology of influenza virus infections. Annu Rev Pathol (2008) 5.37
Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17
Risk factors for human infection with avian influenza A H5N1, Vietnam, 2004. Emerg Infect Dis (2006) 3.96
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc Natl Acad Sci U S A (2009) 3.91
Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J Virol (2007) 3.79
Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Med (2006) 3.60
Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility. Proc Natl Acad Sci U S A (2008) 3.45
2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol (2010) 3.32
Domestic ducks and H5N1 influenza epidemic, Thailand. Emerg Infect Dis (2006) 2.98
Pandemic flu: we are not prepared. MedGenMed (2005) 2.89
Comparative estimation of the reproduction number for pandemic influenza from daily case notification data. J R Soc Interface (2007) 2.83
Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts. Am J Pathol (2006) 2.77
Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog (2009) 2.62
Risk factors for human illness with avian influenza A (H5N1) virus infection in China. J Infect Dis (2009) 2.50
Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans. Am J Pathol (2008) 2.36
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol (2010) 2.35
The pig as a mixing vessel for influenza viruses: Human and veterinary implications. J Mol Genet Med (2008) 2.35
Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment. J Virol (2009) 2.33
Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS One (2008) 2.28
Pandemic influenza--including a risk assessment of H5N1. Rev Sci Tech (2009) 2.27
Anticipated and current preventive behaviors in response to an anticipated human-to-human H5N1 epidemic in the Hong Kong Chinese general population. BMC Infect Dis (2007) 2.26
Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J Virol (2008) 2.23
In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity. J Virol (2010) 2.23
Highly pathogenic avian influenza (H5N1): pathways of exposure at the animal-human interface, a systematic review. PLoS One (2011) 2.22
Poultry-handling practices during avian influenza outbreak, Thailand. Emerg Infect Dis (2005) 2.20
Global transport networks and infectious disease spread. Adv Parasitol (2006) 2.20
Avian influenza and pandemics--research needs and opportunities. N Engl J Med (2005) 2.18
Broad Clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine. PLoS One (2008) 2.18
Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet (2006) 2.10
Family clustering of avian influenza A (H5N1). Emerg Infect Dis (2005) 2.04
Respiratory infections during SARS outbreak, Hong Kong, 2003. Emerg Infect Dis (2005) 2.04
Preliminary findings of a randomized trial of non-pharmaceutical interventions to prevent influenza transmission in households. PLoS One (2008) 2.04
Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob Agents Chemother (2007) 2.03
Pandemic influenza threat and preparedness. Emerg Infect Dis (2006) 2.02
Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays. J Clin Virol (2008) 2.00
Innate immunity to influenza virus infection. Nat Rev Immunol (2014) 1.99
The next influenza pandemic: can it be predicted? JAMA (2007) 1.86
H5N1 influenza A virus and infected human plasma. Emerg Infect Dis (2006) 1.84
The role of receptor binding specificity in interspecies transmission of influenza viruses. Curr Opin Virol (2012) 1.84
Predicting 'airborne' influenza viruses: (trans-) mission impossible? Curr Opin Virol (2011) 1.83
MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. PLoS One (2009) 1.79
H5N1 influenza viruses: outbreaks and biological properties. Cell Res (2009) 1.72
Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine. Influenza Other Respir Viruses (2010) 1.68
What is the best control strategy for multiple infectious disease outbreaks? Proc Biol Sci (2007) 1.68
Virtual epidemic in a virtual city: simulating the spread of influenza in a US metropolitan area. Transl Res (2008) 1.68
Low frequency of infection with avian influenza virus (H5N1) among poultry farmers, Thailand, 2004. Emerg Infect Dis (2008) 1.67
Zoonotic transmission of avian influenza virus (H5N1), Egypt, 2006-2009. Emerg Infect Dis (2010) 1.67
Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses. PLoS Pathog (2008) 1.66
Influenza: the once and future pandemic. Public Health Rep (2010) 1.65
In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses. Antimicrob Agents Chemother (2009) 1.64
A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses. Proc Natl Acad Sci U S A (2008) 1.59
The threat of an avian influenza pandemic. N Engl J Med (2005) 1.56
Pandemic and seasonal influenza: therapeutic challenges. Drug Discov Today (2008) 1.54
Mammalian-transmissible H5N1 influenza: facts and perspective. MBio (2012) 1.48
Real time bayesian estimation of the epidemic potential of emerging infectious diseases. PLoS One (2008) 1.46
Family caregivers in public tertiary care hospitals in Bangladesh: risks and opportunities for infection control. Am J Infect Control (2014) 1.45
Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab')2 in mice. Respir Res (2006) 1.44
The future of research and publication on altered H5N1 viruses. J Infect Dis (2012) 1.39
Emerging pathogens: challenges and successes of molecular diagnostics. J Mol Diagn (2008) 1.38
Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1). Virol J (2010) 1.36
Evidence of infection with H4 and H11 avian influenza viruses among Lebanese chicken growers. PLoS One (2011) 1.35
Avian influenza H5N1 transmission in households, Indonesia. PLoS One (2012) 1.35
Effectiveness and cost-effectiveness of expanded antiviral prophylaxis and adjuvanted vaccination strategies for an influenza A (H5N1) pandemic. Ann Intern Med (2009) 1.33
Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J Virol (2009) 1.32
Avian influenza A H5N1 virus: a continuous threat to humans. Emerg Microbes Infect (2012) 1.30
H5N1 viruses and vaccines. PLoS Pathog (2007) 1.30
Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library. Virol J (2008) 1.30
Pandemic influenza: the inside story. PLoS Biol (2006) 1.27
Detecting emerging transmissibility of avian influenza virus in human households. PLoS Comput Biol (2007) 1.27
Pandemic influenza planning: shouldn't swine and poultry workers be included? Vaccine (2007) 1.27
One family cluster of avian influenza A(H7N9) virus infection in Shandong, China. BMC Infect Dis (2014) 1.26
Officials report first Cambodian case of avian flu. BMJ (2005) 1.26
Pandemic influenza: risk of multiple introductions and the need to prepare for them. PLoS Med (2006) 1.26
A detailed epidemiological and clinical description of 6 human cases of avian-origin influenza A (H7N9) virus infection in Shanghai. PLoS One (2013) 1.25
Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection. Virology (2007) 1.22
Traditional and new influenza vaccines. Clin Microbiol Rev (2013) 1.22
Comparison of the replication of influenza A viruses in Chinese ring-necked pheasants and chukar partridges. J Virol (2006) 1.21
Avian influenza H5N1 and healthcare workers. Emerg Infect Dis (2005) 1.20
Egyptian H5N1 influenza viruses-cause for concern? PLoS Pathog (2012) 1.19
Little evidence for genetic susceptibility to influenza A (H5N1) from family clustering data. Emerg Infect Dis (2007) 1.17
Kinetics and longevity of antibody response to influenza A H5N1 virus infection in humans. Clin Vaccine Immunol (2009) 1.17
Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses. Nat Commun (2013) 1.17
Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry. Proc Natl Acad Sci U S A (2010) 1.17
H5N1 vaccines in humans. Virus Res (2013) 1.16
Simultaneously reconstructing viral cross-species transmission history and identifying the underlying constraints. Philos Trans R Soc Lond B Biol Sci (2013) 1.15
Subclinical infection with avian influenza A (H5N1) virus in cats. Emerg Infect Dis (2007) 1.15
Sensitive detection assays for influenza RNA do not reveal viremia in US blood donors. J Infect Dis (2012) 1.14
Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets. J Virol (2013) 1.13
Likely correlation between sources of information and acceptability of A/H1N1 swine-origin influenza virus vaccine in Marseille, France. PLoS One (2010) 1.12
H5N1 receptor specificity as a factor in pandemic risk. Virus Res (2013) 1.11
Inactivated whole virus influenza A (H5N1) vaccine. Emerg Infect Dis (2007) 1.09
Hemagglutinin receptor specificity and structural analyses of respiratory droplet-transmissible H5N1 viruses. J Virol (2013) 1.08
Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant. J Infect Dis (2011) 1.08
A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses. PLoS One (2011) 1.08
MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis. Influenza Other Respir Viruses (2008) 1.07
Blood screening for influenza. Emerg Infect Dis (2007) 1.07
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med (2003) 29.55
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61
Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis (2007) 24.91
Influenza-associated hospitalizations in the United States. JAMA (2004) 18.23
Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science (2005) 17.19
Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med (2009) 15.02
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol (2009) 12.13
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep (2010) 10.59
The allelic architecture of human disease genes: common disease-common variant...or not? Hum Mol Genet (2002) 10.08
The global circulation of seasonal influenza A (H3N2) viruses. Science (2008) 10.05
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med (2010) 9.90
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science (2009) 8.61
A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science (2007) 8.38
Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States. JAMA (2006) 8.06
Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J Virol (2005) 7.88
A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med (2008) 7.73
Influenza-associated deaths among children in the United States, 2003-2004. N Engl J Med (2005) 6.83
Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis (2007) 6.46
Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model. Proc Natl Acad Sci U S A (2006) 6.35
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Transmission of equine influenza virus to dogs. Science (2005) 6.11
SCAN: SNP and copy number annotation. Bioinformatics (2009) 5.96
Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998. J Infect Dis (2002) 5.92
Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep (2009) 5.80
Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet (2005) 5.70
Multiple Ebola virus transmission events and rapid decline of central African wildlife. Science (2004) 5.49
Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet (2011) 5.43
Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med (2006) 5.42
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007. MMWR Recomm Rep (2007) 5.32
Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis (2007) 5.21
Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis (2003) 5.21
Prevention and Control of Influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (2006) 5.19
Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (2004) 5.00
Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet (2011) 4.93
Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. Clin Infect Dis (2004) 4.83
Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. N Engl J Med (2005) 4.69
Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog (2009) 4.56
A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc Natl Acad Sci U S A (2007) 4.35
Human disease from influenza A (H5N1), Thailand, 2004. Emerg Infect Dis (2005) 4.27
Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet (2011) 4.26
A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med (2012) 4.15
Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet (2005) 4.15
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Transmission of the severe acute respiratory syndrome on aircraft. N Engl J Med (2003) 4.09
Transmission of rabies virus from an organ donor to four transplant recipients. N Engl J Med (2005) 4.05
Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet (2008) 4.01
Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola. J Virol (2006) 4.01
Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol (2006) 4.00
Global concerns regarding novel influenza A (H7N9) virus infections. N Engl J Med (2013) 3.88
Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A (2007) 3.77
Discovery of swine as a host for the Reston ebolavirus. Science (2009) 3.68
Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. J Gen Virol (2005) 3.63
Rocky Mountain spotted fever from an unexpected tick vector in Arizona. N Engl J Med (2005) 3.58
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (2005) 3.50
Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa. Antiviral Res (2009) 3.39
Genetic architecture of transcript-level variation in humans. Am J Hum Genet (2008) 3.36
2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol (2010) 3.32
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (2002) 3.27
Fatal inhalational anthrax in a 94-year-old Connecticut woman. JAMA (2002) 3.26
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet (2013) 3.21
Influenza A H5N1 replication sites in humans. Emerg Infect Dis (2005) 3.21
In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity. Virology (2011) 3.19
Virology, pathology, and clinical manifestations of West Nile virus disease. Emerg Infect Dis (2005) 3.15
Clinical, neurological, and electrophysiological features of nodding syndrome in Kitgum, Uganda: an observational case series. Lancet Neurol (2013) 3.12
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (2003) 2.96
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes (2007) 2.91
An avian influenza H5N1 virus that binds to a human-type receptor. J Virol (2007) 2.77
Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. Emerg Infect Dis (2002) 2.75
A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice. PLoS Pathog (2007) 2.71
Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis (2010) 2.69
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet (2011) 2.68
Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J Infect Dis (2007) 2.65
Mouse DNA contamination in human tissue tested for XMRV. Retrovirology (2010) 2.65
Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses. Vaccine (2008) 2.56
Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol (2005) 2.56
Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001. J Virol (2005) 2.51
Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. J Infect Dis (2012) 2.48
Control measures for severe acute respiratory syndrome (SARS) in Taiwan. Emerg Infect Dis (2003) 2.47
Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis (2004) 2.45
Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events. Virology (2004) 2.44
Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Proc Natl Acad Sci U S A (2010) 2.43
A large outbreak of typhoid fever associated with a high rate of intestinal perforation in Kasese District, Uganda, 2008-2009. Clin Infect Dis (2012) 2.40
Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses. PLoS Pathog (2008) 2.38
Incidence, seasonality and mortality associated with influenza pneumonia in Thailand: 2005-2008. PLoS One (2009) 2.38
Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol (2002) 2.36
Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment. J Virol (2009) 2.33
Real-time PCR assays for detection of bocavirus in human specimens. J Clin Microbiol (2006) 2.29
A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell (2013) 2.28