PubRank

Ulrich Dirnagl

Author PubWeight™ 148.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003 3.89
2 Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke 2008 3.87
3 Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005 3.45
4 Good laboratory practice: preventing introduction of bias at the bench. Stroke 2008 3.27
5 Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 2008 2.98
6 Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol 2002 2.54
7 Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One 2008 2.39
8 Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis 2008 2.26
9 Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res 2006 2.21
10 Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Stroke 2007 2.10
11 Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 2009 2.06
12 Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 2002 2.05
13 Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke 2002 2.00
14 Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci U S A 2010 1.91
15 Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol 2011 1.77
16 Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis 2006 1.75
17 Mechanisms of stroke protection by physical activity. Ann Neurol 2003 1.67
18 Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003 1.65
19 Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 2003 1.61
20 Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 2004 1.61
21 Role of glial cells in cerebral ischemia. Glia 2005 1.58
22 Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005 1.54
23 Reprint: Good laboratory practice: preventing introduction of bias at the bench. J Cereb Blood Flow Metab 2008 1.47
24 Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab 2002 1.44
25 Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis 2007 1.42
26 Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina. Ophthalmic Res 2006 1.42
27 Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 2005 1.40
28 Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke 2006 1.39
29 Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 2002 1.36
30 Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. J Cereb Blood Flow Metab 2010 1.35
31 Modeling stroke in mice - middle cerebral artery occlusion with the filament model. J Vis Exp 2011 1.33
32 SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab 2011 1.32
33 Body weight after stroke: lessons from the obesity paradox. Stroke 2011 1.31
34 Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain 2002 1.30
35 International, multicenter randomized preclinical trials in translational stroke research: it's time to act. J Cereb Blood Flow Metab 2012 1.24
36 Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. J Cereb Blood Flow Metab 2009 1.24
37 Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J Neurosci 2002 1.22
38 Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest 2004 1.22
39 Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke. Stroke 2003 1.21
40 Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab 2002 1.20
41 Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism? Neuroreport 2002 1.20
42 Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem 2005 1.17
43 Fighting publication bias: introducing the Negative Results section. J Cereb Blood Flow Metab 2010 1.17
44 Pharmacological uncoupling of activation induced increases in CBF and CMRO2. J Cereb Blood Flow Metab 2009 1.16
45 In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia. J Cereb Blood Flow Metab 2009 1.15
46 IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One 2011 1.13
47 Withdrawal of statin treatment abrogates stroke protection in mice. Stroke 2003 1.13
48 Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels. J Cereb Blood Flow Metab 2003 1.12
49 Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids. J Neurosci 2007 1.12
50 Functional neurological recovery after spinal cord injury is impaired in patients with infections. Brain 2012 1.11
51 Essential role of interleukin-6 in post-stroke angiogenesis. Brain 2012 1.09
52 Immune responses after acute ischemic stroke or myocardial infarction. Int J Cardiol 2010 1.08
53 Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Mol Cell Neurosci 2004 1.07
54 Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci U S A 2012 1.07
55 Protective conditioning of the brain: expressway or roadblock? J Physiol 2011 1.05
56 Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Res 2009 1.03
57 Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice. J Neurosci Methods 2009 1.01
58 Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J 2005 1.01
59 HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J Neurochem 2004 1.01
60 The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2012 1.00
61 In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody. Stroke 2008 0.99
62 Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Exp Biol Med (Maywood) 2007 0.98
63 Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen. Neuroimage 2008 0.98
64 Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO. Brain 2005 0.97
65 CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia. J Immunol 2010 0.97
66 Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging. Neuroimage 2006 0.97
67 Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia. Stroke 2005 0.96
68 Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 2003 0.96
69 Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining. J Cereb Blood Flow Metab 2011 0.96
70 Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain Pathol 2003 0.96
71 Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J Neuroinflammation 2010 0.95
72 Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space. Ann Neurol 2003 0.95
73 Stroke induced Sarcopenia: muscle wasting and disability after stroke. Int J Cardiol 2013 0.95
74 Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind. Front Neuroenergetics 2010 0.94
75 Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochim Biophys Acta 2009 0.94
76 Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives. J Cereb Blood Flow Metab 2011 0.94
77 Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage. Ann Neurol 2002 0.93
78 Reprint: Good laboratory practice: preventing introduction of bias at the bench. Int J Stroke 2009 0.93
79 Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable. J Cereb Blood Flow Metab 2010 0.93
80 Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials. Brain Res 2006 0.93
81 Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP. Exp Neurol 2006 0.93
82 Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. J Cereb Blood Flow Metab 2006 0.92
83 Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats. Neurosurgery 2002 0.92
84 Hypothermia for Stroke: call to action 2010. Int J Stroke 2010 0.92
85 Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One 2013 0.91
86 Non-resolving aspects of acute inflammation after spinal cord injury (SCI): indices and resolution plateau. Brain Pathol 2011 0.91
87 Brain perfusion SPECT in the mouse: normal pattern according to gender and age. Neuroimage 2012 0.90
88 Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. J Cereb Blood Flow Metab 2010 0.90
89 Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology 2007 0.90
90 Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke 2008 0.90
91 ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo. Am J Physiol Heart Circ Physiol 2003 0.89
92 Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Exp Neurol 2007 0.89
93 Acute pathophysiological processes after ischaemic and traumatic brain injury. Best Pract Res Clin Anaesthesiol 2010 0.89
94 Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study. Mol Imaging 2006 0.88
95 Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF. Cephalalgia 2012 0.87
96 The SCIentinel study--prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS)--study protocol and interim feasibility data. BMC Neurol 2013 0.86
97 Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS). J Cachexia Sarcopenia Muscle 2013 0.86
98 Dysexecutive syndrome after mild cerebral ischemia? Mice learn normally but have deficits in strategy switching. Stroke 2003 0.85
99 Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: effect of systemic hyperoxia or hypoxia. Brain Res 2003 0.85
100 Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach. J Cereb Blood Flow Metab 2013 0.84
101 Ischemia and stroke. Adv Exp Med Biol 2002 0.84
102 Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats. Neuroimage 2010 0.84
103 Determination of the brain-blood partition coefficient for water in mice using MRI. J Cereb Blood Flow Metab 2010 0.84
104 Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke. J Cereb Blood Flow Metab 2013 0.83
105 Evidence of intrathecal immunoglobulin synthesis in stroke: a cohort study. Arch Neurol 2012 0.82
106 Improving the quality of biomedical research: guidelines for reporting experiments involving animals. J Cereb Blood Flow Metab 2011 0.82
107 The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. Neurotoxicology 2012 0.81
108 Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats. Neurocrit Care 2004 0.81
109 Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo. J Cereb Blood Flow Metab 2004 0.81
110 Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion. Stroke 2013 0.80
111 The ischemic cascade and mediators of ischemic injury. Handb Clin Neurol 2009 0.80
112 Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons. Brain Res 2005 0.80
113 REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act. Stroke 2012 0.80
114 Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat. Headache 2006 0.80
115 Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain. J Biomed Opt 2008 0.79
116 Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 2007 0.79
117 A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning. J Cereb Blood Flow Metab 2013 0.78
118 Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. J Neurochem 2003 0.78
119 Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures. Neuropharmacology 2007 0.76
120 5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures. Eur J Pharmacol 2008 0.76
121 A fluorescence-based method to assess plasma protein extravasation in rat dura mater using confocal laser scanning microscopy. Brain Res Brain Res Protoc 2003 0.76
122 Non-invasive surface-stripping for epifluorescence small animal imaging. Biomed Opt Express 2010 0.75
123 Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun 2004 0.75
124 Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons--involvement of heat shock protein 27. Brain Res 2010 0.75
125 Dr Smart talks to Prof Pries and Prof Dirnagl on animal experimentation in biomedical research. Cardiovasc Res 2017 0.75
126 If you have the science, we have the journal! J Cereb Blood Flow Metab 2010 0.75
127 The Journal of Cerebral Blood Flow and Metabolism clinical, inaugural issue. J Cereb Blood Flow Metab 2016 0.75
128 Celebrating the 30th anniversary of our journal. J Cereb Blood Flow Metab 2012 0.75
129 Rotation of Editorial Board Members and new publication formats. J Cereb Blood Flow Metab 2011 0.75
130 Improved protocol for SAGE tag-to-gene allocation. Biotechniques 2003 0.75
131 The microcircualtion--fantastic voyage: introduction. Stroke 2013 0.75