PubRank

Toshiyuki Sakaki

Author PubWeight™ 59.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A 2009 1.40
2 Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers. Drug Metab Dispos 2009 1.34
3 Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol 2005 1.33
4 C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation. J Biol Chem 2004 1.28
5 Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. J Biol Chem 2003 1.21
6 Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3. Biochemistry 2008 1.08
7 Metabolism of vitamin D by human microsomal CYP2R1. Biochem Biophys Res Commun 2004 1.06
8 1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis. Clin J Am Soc Nephrol 2013 1.04
9 The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci 2009 1.03
10 The roles of cytochrome P450 enzymes in prostate cancer development and treatment. Anticancer Res 2012 1.01
11 Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1. J Biol Chem 2005 0.93
12 Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab Dispos 2007 0.92
13 Insight into functional diversity of cytochrome P450 in the white-rot basidiomycete Phanerochaete chrysosporium: involvement of versatile monooxygenase. Biochem Biophys Res Commun 2011 0.92
14 Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer. Anticancer Res 2009 0.91
15 Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs. J Steroid Biochem Mol Biol 2012 0.89
16 Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats. Mol Pharmacol 2006 0.89
17 Metabolism of sesamin by cytochrome P450 in human liver microsomes. Drug Metab Dispos 2010 0.88
18 Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1. Biochemistry 2004 0.88
19 Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans. Drug Metab Dispos 2007 0.87
20 Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J Pharm Sci 2010 0.87
21 Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells. J Steroid Biochem Mol Biol 2011 0.86
22 Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1. Biochemistry 2006 0.86
23 CYP24A1 as a potential target for cancer therapy. Anticancer Agents Med Chem 2014 0.86
24 Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Biochem Biophys Res Commun 2004 0.85
25 Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. Biochem Biophys Res Commun 2004 0.85
26 Metabolism of mono- and dichloro-dibenzo-p-dioxins by Phanerochaete chrysosporium cytochromes P450. Appl Microbiol Biotechnol 2010 0.84
27 Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1. Biochem Biophys Res Commun 2004 0.84
28 Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1. Biochemistry 2008 0.84
29 Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray. J Nutr Sci Vitaminol (Tokyo) 2005 0.83
30 Metabolism of 1alpha,25-dihydroxyvitamin D2 by human CYP24A1. Biochem Biophys Res Commun 2009 0.83
31 Isolation of a new phlorotannin, a potent inhibitor of carbohydrate-hydrolyzing enzymes, from the brown alga Sargassum patens. J Agric Food Chem 2012 0.82
32 Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis. Bioorg Med Chem Lett 2009 0.82
33 Enzymatic properties of cytochrome P450 catalyzing 3'-hydroxylation of naringenin from the white-rot fungus Phanerochaete chrysosporium. Biochem Biophys Res Commun 2009 0.82
34 Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis. FEBS J 2010 0.81
35 A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum. Protein Expr Purif 2005 0.81
36 Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3',4,4',5-pentachlorobiphenyl. J Biochem 2011 0.81
37 Enzymatic properties of human CYP2W1 expressed in Escherichia coli. Biochem Biophys Res Commun 2006 0.81
38 Mechanism of the anti-proliferative action of 25-hydroxy-19-nor-vitamin D(3) in human prostate cells. J Mol Endocrinol 2011 0.81
39 Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D(3)-binding and protein folding. Biochem Biophys Res Commun 2007 0.80
40 Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins. Arch Biochem Biophys 2003 0.80
41 Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver. PLoS One 2013 0.80
42 A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level in rats. Drug Metab Dispos 2007 0.80
43 Development of a synchronous enzyme-reaction system for a highly sensitive enzyme immunoassay. J Biochem 2002 0.80
44 How is sesamin metabolised in the human liver to show its biological effects? Expert Opin Drug Metab Toxicol 2011 0.79
45 Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus. Appl Microbiol Biotechnol 2005 0.79
46 Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1. Drug Metab Dispos 2005 0.79
47 Potent 19-norvitamin D analogs for prostate and liver cancer therapy. Future Med Chem 2012 0.79
48 Homology modeling of human 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5. J Steroid Biochem Mol Biol 2004 0.79
49 Metabolism of 20-epimer of 1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats. Biochem Biophys Res Commun 2003 0.78
50 Metabolism of 26,26,26,27,27,27-F6-1 alpha,23S,25-trihydroxyvitamin D3 by human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 2004 0.78
51 Measurement and characterization of C-3 epimerization activity toward vitamin D3. Arch Biochem Biophys 2005 0.78
52 Synthesis of 2alpha-propoxy-1alpha,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1. Bioorg Med Chem 2009 0.78
53 Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly. J Pharm Pharmacol 2006 0.78
54 Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis. Biochem Biophys Res Commun 2003 0.78
55 Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1. J Cell Biochem 2014 0.77
56 Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1. Drug Metab Dispos 2007 0.77
57 Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant. Appl Microbiol Biotechnol 2006 0.77
58 Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDP-glucuronosyltransferase in human liver microsomes. Drug Metab Dispos 2004 0.77
59 Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver. Drug Metab Dispos 2011 0.77
60 Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats. Drug Metab Dispos 2010 0.77
61 Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver. Drug Metab Dispos 2012 0.77
62 Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites. J Steroid Biochem Mol Biol 2004 0.77
63 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems. J Agric Food Chem 2002 0.77
64 Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. J Biochem 2009 0.77
65 Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos 2011 0.76
66 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver. Drug Metab Dispos 2009 0.76
67 Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab Pharmacokinet 2006 0.76
68 Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant. Biotechnol Lett 2004 0.76
69 Synthesis and biological activities of 14-epi-MART-10 and 14-epi-MART-11: implications for cancer and osteoporosis treatment. Anticancer Res 2009 0.76
70 Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain. Drug Metab Pharmacokinet 2012 0.76
71 cDNA cloning and characterization of feline CYP1A1 and CYP1A2. Life Sci 2006 0.76
72 Purification and characterization of purple acid phosphatase PAP1 from dry powder of sweet potato. Biosci Biotechnol Biochem 2003 0.75
73 Cytochrome P450 2E polymorphism in feline liver. Biochim Biophys Acta 2005 0.75
74 UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1. Biochem Biophys Res Commun 2013 0.75
75 Synthesis and biological activities of 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D(3) and their metabolism by human CYP24A1 and UDP-glucuronosyltransferase. Chem Pharm Bull (Tokyo) 2012 0.75
76 The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. J Biochem 2012 0.75
77 Synthesis and biological activity of 1α,2α,25-trihydroxyvitamin D3: active metabolite of 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP3A4. Chem Pharm Bull (Tokyo) 2014 0.75
78 [Reconsideration of molecular mechanism of vitamin D action based on its metabolism]. Seikagaku 2015 0.75
79 Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice. Neurosci Lett 2005 0.75