PubRank

Mark Zak

Author PubWeight™ 20.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide. Angew Chem Int Ed Engl 2005 2.09
2 Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature 2013 1.52
3 Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. J Am Chem Soc 2005 1.30
4 Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis. J Am Chem Soc 2005 1.26
5 Discovery of a biologically active thiostrepton fragment. J Am Chem Soc 2005 1.20
6 Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors. J Med Chem 2012 1.10
7 Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids. J Org Chem 2002 0.93
8 Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angew Chem Int Ed Engl 2004 0.91
9 Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. J Med Chem 2013 0.89
10 A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angew Chem Int Ed Engl 2002 0.86
11 Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem 2013 0.86
12 Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angew Chem Int Ed Engl 2004 0.86
13 Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor. Xenobiotica 2010 0.84
14 Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system. Angew Chem Int Ed Engl 2005 0.83
15 A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors. J Immunol 2013 0.83
16 Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 2013 0.81
17 Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem 2014 0.81
18 Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angew Chem Int Ed Engl 2003 0.80
19 Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem 2014 0.77
20 Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg Med Chem Lett 2013 0.77
21 Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 2013 0.76
22 Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg Med Chem Lett 2013 0.76
23 Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. Bioorg Med Chem Lett 2013 0.76
24 A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery. J Comput Aided Mol Des 2015 0.75
25 Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angew Chem Int Ed Engl 2002 0.75
26 Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS. Bioanalysis 2014 0.75
27 Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2. Bioorg Med Chem Lett 2012 0.75