Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.

PubWeight™: 3.61‹?› | Rank: Top 1%

🔗 View Article (PMC 546424)

Published in J Clin Invest on February 01, 2005

Authors

Young-sup Yoon1, Andrea Wecker, Lindsay Heyd, Jong-Seon Park, Tengiz Tkebuchava, Kengo Kusano, Allison Hanley, Heather Scadova, Gangjian Qin, Dong-Hyun Cha, Kirby L Johnson, Ryuichi Aikawa, Takayuki Asahara, Douglas W Losordo

Author Affiliations

1: Division of Cardiovascular Medicine, Caritas St. Elizabeth's Medical Center, Boston, Massachusetts 02135, USA. young.yoon@tufts.edu

Articles citing this

(truncated to the top 100)

Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06

Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A (2005) 6.16

Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial. JAMA (2011) 4.52

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56

Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45

Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06

Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res (2011) 2.76

Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J (2009) 2.29

Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25

Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.05

Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells (2007) 1.93

Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89

Regenerating new heart with stem cells. J Clin Invest (2013) 1.83

Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol (2010) 1.69

Increased cardiac myocyte progenitors in failing human hearts. Circulation (2008) 1.68

VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism. J Mol Med (Berl) (2008) 1.67

Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction. Stem Cells (2008) 1.58

Cytoskeletal changes of mesenchymal stem cells during differentiation. ASAIO J (2007) 1.55

Stem cells for ischemic brain injury: a critical review. J Comp Neurol (2009) 1.53

A new role of substance P as an injury-inducible messenger for mobilization of CD29(+) stromal-like cells. Nat Med (2009) 1.47

Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. J Clin Invest (2006) 1.47

Cultured human bone marrow-derived CD31(+) cells are effective for cardiac and vascular repair through enhanced angiogenic, adhesion, and anti-inflammatory effects. J Am Coll Cardiol (2014) 1.47

The promise of cell-based therapies for diabetic complications: challenges and solutions. Circ Res (2010) 1.46

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol (2007) 1.41

Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics (2010) 1.38

Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37

Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol (2005) 1.32

Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue. J Bone Joint Surg Am (2008) 1.28

Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction. J Mol Cell Cardiol (2008) 1.28

Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med (2010) 1.23

Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. Am J Physiol Heart Circ Physiol (2008) 1.22

Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart. Stem Cells Dev (2013) 1.19

Tissue engineering tools for modulation of the immune response. Biotechniques (2011) 1.12

Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res (2014) 1.12

Amniotic mesenchymal stem cells enhance wound healing in diabetic NOD/SCID mice through high angiogenic and engraftment capabilities. PLoS One (2012) 1.11

Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy. Circulation (2009) 1.10

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med (2007) 1.09

Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis. J Cell Mol Med (2006) 1.07

Bone marrow mononuclear stem cells transplanted in rat infarct myocardium improved the electrical conduction without evidence of proarrhythmic effects. Yonsei Med J (2007) 1.05

Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. Lab Invest (2009) 1.03

Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging. J Mol Cell Cardiol (2009) 1.01

Current perspectives on imaging cardiac stem cell therapy. J Nucl Med (2010) 1.00

Effect of in vitro passaging on the stem cell-related properties of tendon-derived stem cells-implications in tissue engineering. Stem Cells Dev (2011) 0.99

Stem cells for heart cell therapies. Tissue Eng Part B Rev (2008) 0.98

Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics (2011) 0.98

Getting to the heart of myocardial stem cells and cell therapy. Circulation (2011) 0.95

Mesenchymal stem cells for cardiac regeneration: translation to bedside reality. Stem Cells Int (2012) 0.92

Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia. Exp Hematol (2010) 0.92

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res (2016) 0.91

Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1. Mol Pharm (2010) 0.90

HIF-1α Overexpression Induces Angiogenesis in Mesenchymal Stem Cells. Biores Open Access (2012) 0.90

Cell therapy with embryonic stem cell-derived cardiomyocytes encapsulated in injectable nanomatrix gel enhances cell engraftment and promotes cardiac repair. ACS Nano (2014) 0.89

Origin of cardiomyocytes in the adult heart. Circ Res (2015) 0.89

c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes. Clin Transl Sci (2009) 0.89

MIQuant--semi-automation of infarct size assessment in models of cardiac ischemic injury. PLoS One (2011) 0.88

Cardiac repair with adult bone marrow-derived cells: the clinical evidence. Antioxid Redox Signal (2009) 0.88

Metabolic modulation and cellular therapy of cardiac dysfunction and failure. J Cell Mol Med (2009) 0.87

Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells. Stem Cell Rev (2012) 0.87

Impact of intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction on left ventricular perfusion and function: a 6-month follow-up gated 99mTc-MIBI single-photon emission computed tomography study. Eur J Nucl Med Mol Imaging (2008) 0.87

Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice. Am J Respir Cell Mol Biol (2008) 0.86

Cell-based therapy for stroke. J Neural Transm (Vienna) (2010) 0.85

Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT. J Transl Med (2012) 0.85

Stem cell therapy and breast cancer treatment: review of stem cell research and potential therapeutic impact against cardiotoxicities due to breast cancer treatment. Front Oncol (2014) 0.85

Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells. Int J Cardiol (2012) 0.84

Cell tracking in cardiac repair: what to image and how to image. Eur Radiol (2011) 0.84

Cell-based approaches for cardiac repair. Ann N Y Acad Sci (2006) 0.84

Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells. Br J Pharmacol (2013) 0.84

Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2. Circ Res (2016) 0.83

Evaluation of neural plasticity in adult stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 0.83

Cell therapy with bone marrow cells for myocardial regeneration. Antioxid Redox Signal (2009) 0.83

Advances in bone marrow-derived cell therapy: CD31-expressing cells as next generation cardiovascular cell therapy. Regen Med (2011) 0.83

Tracking fusion of human mesenchymal stem cells after transplantation to the heart. Stem Cells Transl Med (2015) 0.83

A Caveat Emptor for myocardial regeneration: mechanical without electrical recovery will not suffice. J Mol Cell Cardiol (2006) 0.82

Single cell gene profiling revealed heterogeneity of paracrine effects of bone marrow cells in mouse infarcted hearts. PLoS One (2013) 0.82

Heart regeneration, stem cells, and cytokines. Regen Med Res (2014) 0.82

Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair. Int J Cardiol (2015) 0.82

Combining censored and uncensored data in a U-statistic: design and sample size implications for cell therapy research. Int J Biostat (2011) 0.82

Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells. J Clin Invest (2012) 0.81

Stem cells from in- or outside of the heart: isolation, characterization, and potential for myocardial tissue regeneration. Pediatr Cardiol (2009) 0.81

Proteomic identification of ADAM12 as a regulator for TGF-β1-induced differentiation of human mesenchymal stem cells to smooth muscle cells. PLoS One (2012) 0.81

Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair. Sci Rep (2015) 0.81

Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium. J Heart Lung Transplant (2009) 0.81

Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration. Mol Ther (2017) 0.81

All-trans retinoic acid promotes smooth muscle cell differentiation of rabbit bone marrow-derived mesenchymal stem cells. J Zhejiang Univ Sci B (2010) 0.80

Oxidized low density lipoprotein-induced transdifferentiation of bone marrow-derived smooth muscle-like cells into foam-like cells in vitro. Int J Exp Pathol (2010) 0.80

Thromboxane A(2) modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells. Exp Mol Med (2009) 0.80

The potential of stem cells in the treatment of cardiovascular diseases. Stem Cell Rev (2013) 0.80

Mesenchymal stem cells from fetal heart attenuate myocardial injury after infarction: an in vivo serial pinhole gated SPECT-CT study in rats. PLoS One (2014) 0.80

Stem cell therapy and tissue engineering for correction of congenital heart disease. Front Cell Dev Biol (2015) 0.79

Aging of the inceptive cellular population: the relationship between stem cells and aging. Aging (Albany NY) (2009) 0.79

Increased angiogenesis and improved left ventricular function after transplantation of myoblasts lacking the MyoD gene into infarcted myocardium. PLoS One (2012) 0.78

Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development. Nat Protoc (2010) 0.78

Adhesion proteins, stem cells, and arrhythmogenesis. Cardiovasc Toxicol (2008) 0.78

Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction. Stem Cells Int (2015) 0.77

Cardiovascular repair with bone marrow-derived cells. Blood Res (2013) 0.77

The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia. Biomed Res Int (2014) 0.77

Functional multipotency of stem cells: what do we need from them in the heart? Stem Cells Int (2012) 0.77

Cord lining-mesenchymal stem cells graft supplemented with an omental flap induces myocardial revascularization and ameliorates cardiac dysfunction in a rat model of chronic ischemic heart failure. Tissue Eng Part A (2013) 0.77

Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease. Int J Nanomedicine (2012) 0.77

Articles cited by this

Multilineage potential of adult human mesenchymal stem cells. Science (1999) 66.19

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57

Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71

Marrow stromal cells as stem cells for nonhematopoietic tissues. Science (1997) 17.06

Mechanisms of angiogenesis and arteriogenesis. Nat Med (2000) 13.88

Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell (2001) 12.42

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35

Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res (1999) 11.32

Muscle regeneration by bone marrow-derived myogenic progenitors. Science (1998) 10.66

Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med (2001) 10.36

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 8.87

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation (2002) 7.97

Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature (2002) 7.28

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature (2000) 7.15

Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92

Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest (2001) 6.59

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A (2000) 6.59

From marrow to brain: expression of neuronal phenotypes in adult mice. Science (2000) 6.53

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35

Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science (2000) 6.16

Blood vessel formation: what is its molecular basis? Cell (1996) 5.54

Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest (1999) 5.30

Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation (2003) 5.20

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04

Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol (2003) 4.91

Clinical applications of angiogenic growth factors and their inhibitors. Nat Med (1999) 4.26

Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation (2001) 4.17

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest (2002) 3.90

Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79

Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation (2001) 3.50

A genetic blueprint for cardiac development. Nature (2000) 3.45

Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation (2003) 2.82

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A (2001) 2.77

Congestive heart failure: fifty years of progress. Circulation (2000) 2.61

Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood (2003) 2.26

Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol (2001) 2.22

The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun (1999) 1.97

Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res (1996) 1.95

VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema. J Clin Invest (2003) 1.84

Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int J Exp Pathol (2000) 1.66

The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun (2001) 1.65

Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ Res (1991) 1.63

Normal mammalian muscle differentiation and gene control of isocitrate dehydrogenase synthesis. Proc Natl Acad Sci U S A (1967) 1.58

Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun (2000) 1.40

Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem (2002) 1.33

Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor. Mol Cell Biol (1983) 1.32

Left ventricular remodeling after acute myocardial infarction. Annu Rev Med (1995) 1.25

Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo. Circulation (1998) 1.11

The use of fluorescence in situ hybridization (FISH) on paraffin-embedded tissue sections for the study of microchimerism. Biotechniques (2000) 0.96

Characterization of caveolae from rat heart: localization of postreceptor signal transduction molecules and their rearrangement after norepinephrine stimulation. J Cell Biochem (2000) 0.89

Articles by these authors

Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation (2003) 5.20

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature (2007) 4.63

Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest (2005) 3.77

Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation (2002) 3.65

Ischemic postconditioning during primary percutaneous coronary intervention: the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction (POST) randomized trial. Circulation (2013) 3.49

Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial. Circulation (2007) 2.88

Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation (2002) 2.84

Netrins promote developmental and therapeutic angiogenesis. Science (2006) 2.83

Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation (2003) 2.82

Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res (2009) 2.82

Transfer of fetal cells with multilineage potential to maternal tissue. JAMA (2004) 2.72

CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells. Circulation (2006) 2.51

Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data. J Am Coll Cardiol (2011) 2.50

Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res (2011) 2.31

Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol (2007) 2.27

Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med (2005) 2.24

Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation (2005) 2.18

Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction. Circulation (2006) 2.17

Intact fetal cells in maternal plasma: are they really there? Lancet (2003) 2.09

Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents. Am Heart J (2010) 2.09

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension. J Hypertens (2013) 2.07

The influence of fetal loss on the presence of fetal cell microchimerism: a systematic review. Arthritis Rheum (2003) 2.03

Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation (2006) 2.02

IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res (2008) 2.01

Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res (2011) 1.99

Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation (2005) 1.93

Human studies of angiogenic gene therapy. Circ Res (2009) 1.92

Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation (2006) 1.91

Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation (2003) 1.87

Atherosclerosis 2005: recent discoveries and novel hypotheses. Circulation (2005) 1.87

Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation (2003) 1.86

Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction. Circulation (2004) 1.86

VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema. J Clin Invest (2003) 1.84

Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the Korea Acute Myocardial Infarction Registry. Am Heart J (2011) 1.82

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses. Proc Natl Acad Sci U S A (2009) 1.81

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J (2011) 1.80

Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial). Am J Cardiol (2002) 1.77

Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol (2006) 1.75

Transcatheter closure of atrial septal defect in elderly patients with permanent atrial fibrillation. Catheter Cardiovasc Interv (2009) 1.74

The incidence and clinical impact of stent strut fractures developed after drug-eluting stent implantation. Int J Cardiol (2007) 1.73

Quantification of green fluorescent protein by in vivo imaging, PCR, and flow cytometry: comparison of transgenic strains and relevance for fetal cell microchimerism. Cytometry A (2008) 1.72

Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction. Circ Res (2012) 1.70

Endothelial progenitor cells in neovascularization of infarcted myocardium. J Mol Cell Cardiol (2008) 1.69

Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A (2006) 1.66

Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury. Circ Res (2006) 1.63

Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry). Am J Cardiol (2008) 1.61

Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation (2002) 1.61

CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.61

Development of bioactive peptide amphiphiles for therapeutic cell delivery. Acta Biomater (2009) 1.57

Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J Appl Physiol (1985) (2003) 1.57

Exosomes and cardiac repair after myocardial infarction. Circ Res (2014) 1.56

Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56

Nitric oxide and angiogenesis. Circulation (2002) 1.56

CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism. Circulation (2012) 1.53

Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation (2007) 1.51

Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair. Proc Natl Acad Sci U S A (2011) 1.50

IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J (2006) 1.50

Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo. Exp Hematol (2002) 1.49

Admission hyperglycemia is an independent predictor of acute kidney injury in patients with acute myocardial infarction. Circ J (2014) 1.49