Published in Nature on March 21, 2004
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell (2013) 6.35
Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A (2005) 6.16
Heart regeneration. Nature (2011) 5.91
Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest (2006) 4.51
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Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A (2009) 4.21
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest (2005) 4.10
c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature (2014) 3.78
Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest (2005) 3.61
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The immune system and cardiac repair. Pharmacol Res (2008) 3.42
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27
Retracted Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature (2010) 3.21
Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06
Endothelial progenitor cells: identity defined? J Cell Mol Med (2009) 2.96
Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. J Clin Invest (2005) 2.94
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85
Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol (2005) 2.60
Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58
Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci U S A (2010) 2.49
Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int (2005) 2.43
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun (2007) 2.35
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Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25
Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation (2008) 2.22
Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo. Blood (2009) 2.00
Stem cell paracrine actions and tissue regeneration. Regen Med (2010) 1.99
Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res (2007) 1.90
Human embryonic stem cell transplantation to repair the infarcted myocardium. Heart (2007) 1.86
Development of a network to test strategies in cardiovascular cell delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN). J Cardiovasc Transl Res (2010) 1.84
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CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice. J Clin Invest (2010) 1.82
In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol (2006) 1.81
In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol (2011) 1.80
Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells (2008) 1.80
Stem cells: lost in translation. Nature (2004) 1.79
Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells (2010) 1.78
Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium. Mol Ther (2008) 1.75
Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation (2009) 1.73
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72
Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
Increased cardiac myocyte progenitors in failing human hearts. Circulation (2008) 1.68
Challenges in cardiac tissue engineering. Tissue Eng Part B Rev (2010) 1.66
CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood (2005) 1.64
Monocyte and macrophage heterogeneity in the heart. Circ Res (2013) 1.63
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes (2014) 1.61
Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis (2009) 1.60
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
Development of bioactive peptide amphiphiles for therapeutic cell delivery. Acta Biomater (2009) 1.57
The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (2011) 1.55
Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54
LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J (2010) 1.52
Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy. Neth Heart J (2008) 1.51
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An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50
Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. JACC Cardiovasc Imaging (2012) 1.49
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science (2014) 1.49
Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol (2005) 1.47
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest (2005) 1.46
Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther (2009) 1.45
Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42
Imaging gene expression in human mesenchymal stem cells: from small to large animals. Radiology (2009) 1.37
Cell-based therapies and imaging in cardiology. Eur J Nucl Med Mol Imaging (2005) 1.36
Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up. Eur Heart J (2009) 1.34
Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem (2009) 1.33
In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep (2014) 1.32
Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol (2005) 1.32
Cell-based therapy for prevention and reversal of myocardial remodeling. Am J Physiol Heart Circ Physiol (2012) 1.31
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med (2011) 1.31
Biomimetic approach to cardiac tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.31
Regeneration of the heart. EMBO Mol Med (2011) 1.27
Features of cardiomyocyte proliferation and its potential for cardiac regeneration. J Cell Mol Med (2008) 1.27
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J Clin Invest (2004) 1.23
Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A (2006) 1.23
Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. Am J Physiol Heart Circ Physiol (2008) 1.22
CD34-positive stem cells: in the treatment of heart and vascular disease in human beings. Tex Heart Inst J (2011) 1.21
Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther (2010) 1.19
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Cardiac regeneration. Curr Top Dev Biol (2012) 1.17
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proc Natl Acad Sci U S A (2013) 1.17
Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease. J Am Coll Cardiol (2010) 1.17
Vascular endothelial growth factor in heart failure. Nat Rev Cardiol (2013) 1.16
Time to do something about reproducibility. Elife (2014) 1.16
Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation. Microvasc Res (2010) 1.16
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16
Human embryonic stem cells and cardiac repair. Transplant Rev (Orlando) (2008) 1.15
CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow. PLoS One (2011) 1.15
Stem cell recruitment after injury: lessons for regenerative medicine. Regen Med (2012) 1.14
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med (2006) 1.13
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Proc Natl Acad Sci U S A (2009) 1.12
Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res (2014) 1.12
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29
Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell (2013) 6.35
Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
Stems cells and the pathways to aging and cancer. Cell (2008) 5.99
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med (2005) 5.68
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell (2007) 5.28
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 5.22
Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21
Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell (2004) 5.20
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell (2007) 5.17
Plasticity of adult stem cells. Cell (2004) 5.13
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature (2010) 5.05
Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell (2008) 4.92
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature (2012) 4.64
In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37
Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32
JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell (2004) 4.28
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A (2003) 4.09
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05
Coronary arteries form by developmental reprogramming of venous cells. Nature (2010) 3.95
Cancer stem cells in solid tumors. Curr Opin Biotechnol (2007) 3.91
Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature (2008) 3.87
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 3.87
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med (2009) 3.82
Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol (2011) 3.81
Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74
Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell (2007) 3.59
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A (2009) 3.57
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A (2010) 3.54
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53
Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A (2002) 3.50
No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol (2008) 3.46
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A (2010) 3.41
Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med (2006) 3.39
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A (2014) 3.39
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell (2010) 3.37
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science (2014) 3.37
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25
Retracted Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature (2010) 3.21
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science (2014) 3.14
Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (2005) 3.11
A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05
Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03
Isolation and characterization of a protochordate histocompatibility locus. Nature (2005) 2.96
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A (2006) 2.94
Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med (2005) 2.92
Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell (2012) 2.91
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell (2008) 2.88
Transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era. Circulation (2013) 2.87
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85
Retracted Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood (2008) 2.84
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med (2010) 2.79
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science (2007) 2.69
Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest (2011) 2.69
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood (2011) 2.69
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med (2010) 2.68
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Ethics. The ISSCR guidelines for human embryonic stem cell research. Science (2007) 2.62
Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood (2008) 2.52
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell (2013) 2.46
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev (2009) 2.46