PubRank

Douglas J Hilton

Author PubWeight™ 110.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 2003 4.90
2 Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 2006 3.94
3 The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004 3.76
4 The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013 3.15
5 The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 2008 3.07
6 The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 2002 2.64
7 SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004 2.30
8 ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res 2011 2.23
9 SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet 2008 2.19
10 NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity 2012 2.14
11 Inhibitors of cytokine signal transduction. J Biol Chem 2003 2.10
12 Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 2005 2.01
13 Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol 2002 1.92
14 General nature of the STAT3-activated anti-inflammatory response. J Immunol 2006 1.90
15 Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A 2004 1.81
16 Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood 2010 1.71
17 Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood 2011 1.69
18 SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 2005 1.66
19 Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 2009 1.61
20 Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 2003 1.55
21 Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol 2008 1.53
22 The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem 2006 1.45
23 Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1. Biochem J 2013 1.45
24 The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell 2006 1.41
25 A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet 2008 1.40
26 Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol 2002 1.39
27 Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 2003 1.38
28 A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol 2007 1.34
29 ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 2011 1.30
30 SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol 2002 1.28
31 SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 2002 1.27
32 Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J Biol Chem 2002 1.26
33 Suppression of cytokine signaling: the SOCS perspective. Cytokine Growth Factor Rev 2013 1.20
34 Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 2002 1.18
35 Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A 2009 1.18
36 Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects. Mol Endocrinol 2004 1.16
37 Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Res 2010 1.14
38 The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood 2007 1.13
39 Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood 2005 1.13
40 Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci U S A 2010 1.09
41 Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A 2006 1.09
42 Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood 2010 1.09
43 Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci U S A 2014 1.08
44 The art and design of genetic screens: mouse. Nat Rev Genet 2005 1.08
45 Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood 2008 1.07
46 Development of hydrocephalus in mice lacking SOCS7. Proc Natl Acad Sci U S A 2004 1.07
47 Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 2003 1.07
48 Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem 2006 1.05
49 Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood 2009 1.04
50 Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol 2007 1.03
51 An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc Natl Acad Sci U S A 2007 1.01
52 Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 2005 1.00
53 Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J Biol Chem 2010 0.99
54 A new role for SOCS in insulin action. Suppressor of cytokine signaling. Sci STKE 2003 0.99
55 Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene 2003 0.97
56 Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A 2002 0.96
57 Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 2008 0.95
58 Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood 2007 0.95
59 The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways. Curr Opin Hematol 2007 0.95
60 SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol 2004 0.94
61 Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease. Gastroenterology 2002 0.92
62 An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. Am J Pathol 2002 0.91
63 Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Exp Hematol 2008 0.91
64 Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics 2006 0.90
65 Epigenetic regulator Smchd1 functions as a tumor suppressor. Cancer Res 2012 0.90
66 Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors 2009 0.89
67 A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol 2009 0.88
68 Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 2004 0.88
69 A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc Natl Acad Sci U S A 2006 0.87
70 Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma. Blood 2013 0.84
71 Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A 2010 0.84
72 Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha. Growth Factors 2007 0.84
73 More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Blood 2006 0.82
74 Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol 2008 0.81
75 Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol 2011 0.80
76 An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood 2011 0.79
77 A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity. Growth Factors 2010 0.78
78 Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest 2017 0.75
79 Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proc Natl Acad Sci U S A 2011 0.75
80 Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1. Immunity 2003 0.75
81 Donald Metcalf (1929-2014). Cell 2015 0.75
82 Probabilistic analysis of recessive mutagenesis screen strategies. Mamm Genome 2007 0.75
83 Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A 2015 0.75
84 A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction. J Biol Chem 2002 0.75
85 Special Issue Collection: In Memoriam. Stem Cells 2015 0.75
86 In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology. Exp Hematol 2015 0.75