Published in J Biol Chem on February 03, 2005
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol (2007) 2.16
Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology (2010) 2.02
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Hedgehog signaling in the liver. J Hepatol (2010) 1.80
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology (2009) 1.55
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev (2010) 1.33
Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One (2010) 1.30
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Hedgehog signalling in gut development, physiology and cancer. J Physiol (2011) 1.09
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Physiol Gastrointest Liver Physiol (2008) 1.05
Gastrin - active participant or bystander in gastric carcinogenesis? Nat Rev Cancer (2006) 1.05
The role of hedgehog signaling during gastric regeneration. J Gastroenterol (2009) 1.02
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin (2012) 0.93
Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis. World J Gastroenterol (2006) 0.91
Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling. Dev Dyn (2008) 0.90
The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci (2010) 0.90
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol (2010) 0.89
How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell. Physiol Genomics (2009) 0.88
Gastric stem cells and gastric cancer stem cells. Anat Cell Biol (2013) 0.86
Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? Curr Opin Endocrinol Diabetes Obes (2009) 0.85
The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology (2013) 0.83
Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer. Oncotarget (2015) 0.82
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling. World J Gastroenterol (2016) 0.80
Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin. Am J Pathol (2015) 0.79
Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice. Dig Dis Sci (2009) 0.79
Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment. Cancer Treat Rev (2013) 0.78
Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach. World J Gastrointest Pathophysiol (2011) 0.78
The role of Sonic Hedgehog as a regulator of gastric function and differentiation. Vitam Horm (2012) 0.77
Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis. World J Gastrointest Pathophysiol (2010) 0.75
Notch and hedgehog signaling cooperate to maintain self-renewal of human embryonic stem cells exposed to low oxygen concentration. Int J Stem Cells (2010) 0.75
From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell Commun Signal (2017) 0.75
Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions. Cell Mol Gastroenterol Hepatol (2017) 0.75
Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology (2005) 2.68
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene (2005) 1.59
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology (2009) 1.55
Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology (2007) 1.45
Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology (2002) 1.43
Use of a third-generation perfluorocarbon for preservation of rat DCD liver grafts. J Surg Res (2011) 1.41
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest (2005) 1.36
Acinetobacter lwoffii infection and gastritis. Microbes Infect (2003) 1.31
Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem (2007) 1.26
Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology (2012) 1.26
Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol (2011) 1.23
Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. J Clin Invest (2008) 1.22
Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proc Natl Acad Sci U S A (2003) 1.19
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology (2010) 1.17
Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol (2005) 1.15
Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89. Am J Pathol (2003) 1.10
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One (2013) 1.06
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS Lett (2007) 1.03
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology (2006) 1.03
An isoform of ZBP-89 predisposes the colon to colitis. Nucleic Acids Res (2006) 1.02
ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology (2013) 1.00
Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment. Proc Natl Acad Sci U S A (2004) 1.00
Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia. Int J Cancer (2007) 0.99
Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology (2013) 0.98
Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89. J Biol Chem (2007) 0.98
Hypergastrinemia in response to gastric inflammation suppresses somatostatin. Am J Physiol Gastrointest Liver Physiol (2002) 0.96
The full-length unprocessed hedgehog protein is an active signaling molecule. J Biol Chem (2009) 0.95
A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J (2012) 0.93
Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia. Mamm Genome (2006) 0.92
Butyrate increases IL-23 production by stimulated dendritic cells. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol (2012) 0.90
Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J Biol Chem (2004) 0.90
The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci (2010) 0.90
Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer. Int J Gastrointest Cancer (2002) 0.90
The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol (2015) 0.90
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol (2010) 0.89
Transcription factor ZBP-89 is required for STAT1 constitutive expression. Nucleic Acids Res (2003) 0.89
Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol (2008) 0.89
The Epstein-Barr virus protein BMRF1 activates gastrin transcription. J Virol (2005) 0.88
ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. Biochem Biophys Res Commun (2007) 0.88
Intracellular mechanisms mediating the anti-apoptotic action of gastrin. Biochem Biophys Res Commun (2004) 0.87
Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NFκB pathway activation: the use of a novel in vitro model to study epithelial response to infection. Helicobacter (2014) 0.87
AGA Institute Future Trends Committee report: the future of gastroenterology training programs in the United States. Gastroenterology (2008) 0.87
Role of small GTP binding proteins in the growth-promoting and antiapoptotic actions of gastrin. Am J Physiol Gastrointest Liver Physiol (2004) 0.87
Sonic Hedgehog contributes to gastric mucosal restitution after injury. Lab Invest (2012) 0.86
Intestinal alkaline phosphatase gene expression is activated by ZBP-89. Am J Physiol Gastrointest Liver Physiol (2005) 0.86
Inflammation and cancer III. Somatostatin and the innate immune system. Am J Physiol Gastrointest Liver Physiol (2004) 0.86
Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori. Regul Pept (2005) 0.86
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma. Biochim Biophys Acta (2013) 0.86
Functional role of bone morphogenetic protein-4 in isolated canine parietal cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.86
Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? Curr Opin Endocrinol Diabetes Obes (2009) 0.85
ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells. Biochim Biophys Acta (2010) 0.84
Regulated expression of the human gastrin gene in mice. Regul Pept (2008) 0.84
IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Lab Invest (2012) 0.84
Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun (2008) 0.84
Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Am J Gastroenterol (2013) 0.84
The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology (2013) 0.83
Modulating the cytokine response to treat Helicobacter gastritis. Biochem Pharmacol (2005) 0.83
P53 mutants suppress ZBP-89 function. Anticancer Res (2006) 0.82
Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89. Mol Endocrinol (2006) 0.82
Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PLoS One (2013) 0.82
Extracellular signal-regulated protein kinases mediate H(+),K(+)-ATPase alpha-subunit gene expression. Biochem Biophys Res Commun (2002) 0.81
Identification of zinc finger binding protein 89 (ZBP-89) as a transcriptional activator for a major bovine growth hormone receptor promoter. Mol Cell Endocrinol (2006) 0.81
The Akt and MAPK signal-transduction pathways regulate growth factor actions in isolated gastric parietal cells. Gastroenterology (2004) 0.81
Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. Cell Cycle (2012) 0.81
Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function. Helicobacter (2005) 0.80
Plasma Shh levels reduced in pancreatic cancer patients. Pancreas (2012) 0.80
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One (2012) 0.79
Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol (2011) 0.79
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest. Cancer Lett (2009) 0.79
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest (2016) 0.79