Published in Gastroenterology on March 03, 2010
Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol (2011) 2.18
Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res (2010) 1.40
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology (2010) 1.38
Intestinal myofibroblasts: targets for stem cell therapy. Am J Physiol Gastrointest Liver Physiol (2011) 1.33
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Hedgehog signalling in gut development, physiology and cancer. J Physiol (2011) 1.09
Intestinal mesenchymal cells. Curr Gastroenterol Rep (2010) 1.05
Intestinal stem cells. Curr Gastroenterol Rep (2010) 1.03
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol (2011) 1.01
Hedgehog signaling: networking to nurture a promalignant tumor microenvironment. Mol Cancer Res (2011) 0.94
Intestinal barrier: Molecular pathways and modifiers. World J Gastrointest Pathophysiol (2013) 0.90
Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10. PLoS One (2012) 0.88
IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice. J Pediatr Surg (2013) 0.84
Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83
Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem (2013) 0.83
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev (2015) 0.81
Plasma Shh levels reduced in pancreatic cancer patients. Pancreas (2012) 0.80
Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome. Oncotarget (2015) 0.79
The regulatory niche of intestinal stem cells. J Physiol (2016) 0.79
Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. PLoS One (2014) 0.77
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat Commun (2016) 0.77
Hedgehog signalling is downregulated in celiac disease. Can J Gastroenterol (2013) 0.77
Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation. PLoS One (2015) 0.75
Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS One (2013) 0.75
Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proc Natl Acad Sci U S A (2016) 0.75
Effect of cytostatic proline rich polypeptide-1 on tumor suppressors of inflammation pathway signaling in chondrosarcoma. Mol Clin Oncol (2016) 0.75
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97
The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol (2008) 7.91
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol (2007) 7.64
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol (2005) 4.86
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development (2002) 4.80
Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest (2005) 4.26
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development (2004) 2.62
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med (2009) 2.45
A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A (2008) 2.05
The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development (2000) 2.03
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol (2009) 1.96
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn (2004) 1.75
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development (2007) 1.65
Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. Immunology (2007) 1.59
Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. J Immunol (2006) 1.50
Significance of smooth muscle/anti-actin autoantibodies in celiac disease. Acta Gastroenterol Latinoam (2005) 1.42
Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol (2006) 1.28
Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics (2007) 1.27
Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells. J Immunol (2002) 1.24
Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes. J Immunol (2002) 1.13
Extraintestinal manifestations of celiac disease. Curr Gastroenterol Rep (2006) 1.10
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med (2008) 1.02
Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling. J Leukoc Biol (2008) 0.98
Overview of gut immunology. Adv Exp Med Biol (2008) 0.94
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol (2005) 3.63
Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology (2005) 2.68
Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development (2004) 2.62
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development (2011) 2.45
A pilot study of the association of low plasma adiponectin and Barrett's esophagus. Am J Gastroenterol (2008) 2.39
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5. Virology (2006) 2.12
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J Invest Dermatol (2009) 2.06
Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology (2006) 1.96
Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection. J Virol (2006) 1.96
Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature. Inflamm Bowel Dis (2010) 1.86
Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine. Inflamm Bowel Dis (2010) 1.84
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun (2003) 1.70
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain. J Virol (2007) 1.60
Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene (2005) 1.59
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58
Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Med (2013) 1.54
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A (2006) 1.53
Biochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha protein. J Virol (2008) 1.48
Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology (2007) 1.45
The role of dendritic cells in the development of acute dextran sulfate sodium colitis. J Immunol (2007) 1.45
The development of vaccine viruses against pandemic A(H1N1) influenza. Vaccine (2011) 1.44
Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol (2006) 1.44
Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis. Inflamm Bowel Dis (2010) 1.44
The ability of multimerized cyclophilin A to restrict retrovirus infection. Virology (2007) 1.43
Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology (2002) 1.43
Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancer. Cancer Res (2012) 1.41
p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest (2010) 1.41
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem (2005) 1.39
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest (2005) 1.36
Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy. Infect Immun (2012) 1.36
The gut microbiome in health and in disease. Curr Opin Gastroenterol (2015) 1.33
Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Dev Biol (2007) 1.32
Acinetobacter lwoffii infection and gastritis. Microbes Infect (2003) 1.31
High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma. Eur J Cancer (2013) 1.29
Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics (2007) 1.27
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Blood (2008) 1.27
Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem (2007) 1.26
Isomer separation, conformation control of flexible cyclohexanedicarboxylate ligand in cadmium complexes. Chem Commun (Camb) (2004) 1.25
Signal extraction using ensemble empirical mode decomposition and sparsity in pipeline magnetic flux leakage nondestructive evaluation. Rev Sci Instrum (2009) 1.24
Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol (2011) 1.23
Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. J Clin Invest (2008) 1.22
Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS. Stem Cells (2013) 1.22
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi. Proc Natl Acad Sci U S A (2012) 1.20
Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever. Arthritis Rheum (2004) 1.20
Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proc Natl Acad Sci U S A (2003) 1.19
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development (2011) 1.18
Villin: A marker for development of the epithelial pyloric border. Dev Dyn (2002) 1.15
Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol (2005) 1.15
Utilization, price, and spending trends for antidepressants in the US Medicaid Program. Res Social Adm Pharm (2008) 1.15
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Mol Cell (2013) 1.14
The association between methylenetetrahydrofolate reductase C677T polymorphism and pre-eclampsia risk: appraisal of a recent meta-analysis. Hypertens Res (2013) 1.11
Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents. Food Chem Toxicol (2010) 1.10
Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89. Am J Pathol (2003) 1.10
Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus. Gastroenterology (2013) 1.09
Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin. Exp Biol Med (Maywood) (2009) 1.09
Genetic variants in pre-eclampsia should be interpreted with caution. Hum Reprod Update (2013) 1.08
Mathematical model for radial expansion and conflation of intratumoral infectious centers predicts curative oncolytic virotherapy parameters. PLoS One (2013) 1.08
Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly. PLoS One (2011) 1.07
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis. Infect Immun (2011) 1.07
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One (2013) 1.06
Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. J Virol (2003) 1.05
Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05
Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance. Dev Biol (2013) 1.04
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS Lett (2007) 1.03
Kinetic properties of ASC protein aggregation in epithelial cells. J Cell Physiol (2010) 1.03
Isolation and preliminary characterization of a large Babesia sp. from sheep and goats in the eastern part of Gansu Province, China. Parasitol Res (2002) 1.03
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology (2006) 1.03
Intestinal dysbiosis in inflammatory bowel disease. Gut Microbes (2011) 1.02
Expression of a soluble TGF-beta receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacy. J Immunol (2008) 1.02
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med (2008) 1.02
RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway. RNA (2009) 1.02
An isoform of ZBP-89 predisposes the colon to colitis. Nucleic Acids Res (2006) 1.02
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol (2011) 1.01
Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol (2013) 1.01
ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology (2013) 1.00
Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion. PLoS One (2013) 1.00