Published in J Biol Chem on February 03, 2005
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut (2008) 2.77
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab (2010) 2.11
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors. Pain (2007) 1.60
Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem (2006) 1.53
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci (2008) 1.48
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci U S A (2006) 1.39
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Pain (2008) 1.31
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev (2012) 1.25
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. J Physiol (2006) 1.25
Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol Biol Cell (2006) 1.20
Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch (2005) 1.20
Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch (2007) 1.16
Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol (2008) 1.15
Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol (2013) 1.14
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. J Neurosci (2008) 1.10
Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J Neurosci (2014) 1.06
The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Mol Pain (2006) 1.04
Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. Trends Pharmacol Sci (2008) 1.01
From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nat Rev Urol (2011) 1.01
Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci (2013) 0.99
Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. J Gen Physiol (2012) 0.98
TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis (2012) 0.98
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. Eur J Neurosci (2008) 0.97
Physiology and pharmacology of the vanilloid receptor. Curr Neuropharmacol (2006) 0.96
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function. Brain Res (2008) 0.96
TRPV1: a target for next generation analgesics. Curr Neuropharmacol (2008) 0.95
Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold. J Gen Physiol (2013) 0.93
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling. J Biol Chem (2010) 0.93
Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem (2012) 0.93
Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons. Anesthesiology (2011) 0.92
A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate. J Neurosci (2011) 0.92
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel. J Neurosci (2012) 0.90
Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. J Biol Chem (2008) 0.90
Regulation of transient receptor potential channels by the phospholipase C pathway. Adv Biol Regul (2013) 0.90
Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction. Pflugers Arch (2014) 0.89
N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor. J Biol Chem (2012) 0.89
New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view. Pharmaceuticals (Basel) (2011) 0.87
A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. Br J Pharmacol (2012) 0.87
Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology (Berl) (2010) 0.87
Small molecule vanilloid TRPV1 receptor antagonists approaching drug status: can they live up to the expectations? Naunyn Schmiedebergs Arch Pharmacol (2006) 0.86
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. PLoS One (2013) 0.86
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease? Curr Opin Cardiol (2008) 0.86
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem (2012) 0.85
Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by norepinephrine in nociceptive neurons. J Physiol (2017) 0.85
Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca2+ response elicited by repeated application of capsaicin in rat DRG neurons. Am J Physiol Regul Integr Comp Physiol (2010) 0.85
PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150. Biochem J (2010) 0.85
Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia. J Neurosci (2013) 0.85
Propofol modulates agonist-induced transient receptor potential vanilloid subtype-1 receptor desensitization via a protein kinase Cepsilon-dependent pathway in mouse dorsal root ganglion sensory neurons. Anesthesiology (2010) 0.85
AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin. Mol Pain (2011) 0.84
Phosphoinositide regulation of TRPV1 revisited. Pflugers Arch (2015) 0.84
P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons. Am J Physiol Regul Integr Comp Physiol (2010) 0.83
Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. Cell Signal (2012) 0.83
Cannabinoid WIN 55,212-2 inhibits TRPV1 in trigeminal ganglion neurons via PKA and PKC pathways. Neurol Sci (2011) 0.83
TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain (2012) 0.81
Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk. PLoS One (2014) 0.80
Cold hyposensitivity after topical application of capsaicin in humans. Exp Brain Res (2008) 0.80
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats. J Neurosci Methods (2011) 0.80
Different desensitization patterns for sensory and vascular TRPV1 populations in the rat: expression, localization and functional consequences. PLoS One (2013) 0.79
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies. Pharmaceuticals (Basel) (2016) 0.78
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Channels (Austin) (2015) 0.78
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain (2015) 0.77
Capsaicin up-regulates protease-activated receptor-4 mRNA and protein in primary cultured dorsal root ganglion neurons. Cell Mol Neurobiol (2012) 0.76
New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review. Channels (Austin) (2015) 0.76
Phosphoinositide signaling in somatosensory neurons. Adv Biol Regul (2015) 0.76
The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence. Channels (Austin) (2015) 0.76
Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons. J Physiol (2016) 0.76
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem (2017) 0.75
High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer. Oncotarget (2017) 0.75
Integrating TRPV1 Receptor Function with Capsaicin Psychophysics. Adv Pharmacol Sci (2016) 0.75
Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening. Sci Rep (2016) 0.75
Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS One (2014) 0.75
An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain. Mol Ther Methods Clin Dev (2016) 0.75
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Pain (2017) 0.75
Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology. Evid Based Complement Alternat Med (2017) 0.75
Repeat low-level blast exposure increases transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1) expression in the trigeminal ganglion. PLoS One (2017) 0.75
[Direct inhibition of TRPV1 by acetylsalicylic acid : New effect of an old drug]. Schmerz (2015) 0.75
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med (2012) 3.31
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem (2003) 1.66
PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia. J Neurosci (2002) 1.60
TRPA1 and substance P mediate colitis in mice. Gastroenterology (2011) 1.35
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. J Pharmacol Exp Ther (2006) 1.21
Secondary use of routinely collected patient data in a clinical trial: an evaluation of the effects on patient recruitment and data acquisition. Int J Med Inform (2012) 1.17
A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents. Mol Cell Neurosci (2003) 1.13
Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia. Brain (2010) 1.04
Local anesthetic-like inhibition of voltage-gated Na(+) channels by the partial μ-opioid receptor agonist buprenorphine. Anesthesiology (2012) 1.02
Activation of TRPA1 by membrane permeable local anesthetics. Mol Pain (2011) 0.96
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology (2009) 0.95
A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. Eur J Neurosci (2007) 0.95
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem (2010) 0.93
Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation. J Biol Chem (2013) 0.89
Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol (2010) 0.86
Evaluating predictive modeling algorithms to assess patient eligibility for clinical trials from routine data. BMC Med Inform Decis Mak (2013) 0.85
Sensitization of nociceptive ion channels by inhaled anesthetics--a pain in the gas? Mol Pharmacol (2008) 0.77
Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg (2008) 0.77
[The Scientific Working Group, "Young Scientists" of the German Society for Anesthesiology and Intensive Care Medicine]. Anasthesiol Intensivmed Notfallmed Schmerzther (2011) 0.75