Published in J Pharmacol Exp Ther on September 27, 2006
Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges. J Physiol (2007) 1.61
Single-cell analysis of sodium channel expression in dorsal root ganglion neurons. Mol Cell Neurosci (2010) 1.30
Sodium channelopathies and pain. Pflugers Arch (2010) 1.22
Nav1.7 expression is increased in painful human dental pulp. Mol Pain (2008) 1.00
Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology (2009) 0.98
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology (2009) 0.95
PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice. J Clin Invest (2012) 0.93
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators. J Neurosci (2014) 0.88
The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5. Br J Pharmacol (2014) 0.86
Animal toxins can alter the function of Nav1.8 and Nav1.9. Toxins (Basel) (2012) 0.86
Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve. Br J Pharmacol (2009) 0.85
Structural determinants of drugs acting on the Nav1.8 channel. J Biol Chem (2009) 0.84
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J Physiol (2013) 0.84
The tetrodotoxin-resistant Na+ channel Na (v)1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors. Pflugers Arch (2010) 0.81
Evidence of a physiological role for use-dependent inactivation of NaV1.8 sodium channels. J Physiol (2008) 0.79
Conduction properties distinguish unmyelinated sympathetic efferent fibers and unmyelinated primary afferent fibers in the monkey. PLoS One (2010) 0.79
Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons. Mol Pain (2013) 0.78
Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg (2008) 0.77
Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions. Acta Pharmacol Sin (2015) 0.76
Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis. Sci Rep (2016) 0.75
Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci (2004) 4.20
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med (2012) 3.31
Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev (2008) 2.90
Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science (2006) 2.86
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem (2005) 1.86
Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability. Neurotoxicology (2005) 1.70
Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci (2005) 1.68
Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem (2003) 1.66
Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation. J Neurosci (2006) 1.61
PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia. J Neurosci (2002) 1.60
SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Neuron (2010) 1.35
TRPA1 and substance P mediate colitis in mice. Gastroenterology (2011) 1.35
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
RGS6, a modulator of parasympathetic activation in heart. Circ Res (2010) 1.32
Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2. Neuron (2013) 1.23
Secondary use of routinely collected patient data in a clinical trial: an evaluation of the effects on patient recruitment and data acquisition. Int J Med Inform (2012) 1.17
A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents. Mol Cell Neurosci (2003) 1.13
Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia. Brain (2010) 1.04
Local anesthetic-like inhibition of voltage-gated Na(+) channels by the partial μ-opioid receptor agonist buprenorphine. Anesthesiology (2012) 1.02
Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. J Neurosci (2012) 0.99
Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function. Channels (Austin) (2007) 0.98
Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J (2006) 0.96
Activation of TRPA1 by membrane permeable local anesthetics. Mol Pain (2011) 0.96
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology (2009) 0.95
A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. Eur J Neurosci (2007) 0.95
Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling. J Biol Chem (2011) 0.93
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem (2010) 0.93
Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J Biol Chem (2012) 0.91
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel. J Neurosci (2012) 0.90
Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation. J Biol Chem (2013) 0.89
Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol (2010) 0.86
Evaluating predictive modeling algorithms to assess patient eligibility for clinical trials from routine data. BMC Med Inform Decis Mak (2013) 0.85
Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. PLoS One (2013) 0.84
Tissue preparation and immunostaining of mouse sensory nerve fibers innervating skin and limb bones. J Vis Exp (2012) 0.83
TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain (2012) 0.81
The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. PLoS One (2012) 0.80
Abnormal trigeminal sensory processing in obese mice. Pain (2016) 0.78
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain (2015) 0.77
Sensitization of nociceptive ion channels by inhaled anesthetics--a pain in the gas? Mol Pharmacol (2008) 0.77
Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg (2008) 0.77
Anasthesiol Intensivmed Notfallmed Schmerzther (2017) 0.75
[The Scientific Working Group, "Young Scientists" of the German Society for Anesthesiology and Intensive Care Medicine]. Anasthesiol Intensivmed Notfallmed Schmerzther (2011) 0.75