PubRank

Makoto M Taketo

Author PubWeight™ 250.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 2005 6.90
2 Subtypes of medulloblastoma have distinct developmental origins. Nature 2010 5.94
3 Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev 2004 4.78
4 Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 2012 4.58
5 Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 2005 4.34
6 Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 2011 4.04
7 Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 2006 3.98
8 The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell 2007 3.54
9 Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 2008 3.22
10 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 2009 3.18
11 Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol 2006 3.17
12 Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J 2002 3.06
13 beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol 2003 2.85
14 Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 2004 2.82
15 Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A 2007 2.61
16 Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A 2007 2.56
17 ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol 2005 2.50
18 Stabilization of beta-catenin impacts pancreas growth. Development 2006 2.44
19 Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet 2006 2.43
20 Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci 2007 2.41
21 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 2006 2.40
22 SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet 2007 2.39
23 Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 2012 2.33
24 Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 2007 2.26
25 Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 2006 2.25
26 Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008 2.23
27 β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell 2011 2.17
28 Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell 2002 2.14
29 Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest 2007 2.12
30 Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol 2003 2.07
31 Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 2002 2.05
32 Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 2008 2.04
33 Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci 2009 2.03
34 The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 2010 2.01
35 Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 2004 2.01
36 Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res 2002 2.00
37 Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003 1.99
38 Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 2008 1.96
39 Wnt signals mediate a fate decision between otic placode and epidermis. Development 2006 1.94
40 Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 2005 1.93
41 Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. Hum Mol Genet 2008 1.90
42 Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet 2008 1.80
43 Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 2003 1.73
44 Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur J Neurosci 2004 1.71
45 Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 2005 1.66
46 Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development 2007 1.63
47 Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 2002 1.62
48 Wt1 negatively regulates beta-catenin signaling during testis development. Development 2008 1.61
49 JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Δ716) mice. Gastroenterology 2011 1.61
50 Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A 2007 1.60
51 Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. J Biol Chem 2008 1.60
52 Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 2002 1.60
53 Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol Reprod 2005 1.59
54 Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. J Neurosci 2005 1.58
55 Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 2011 1.57
56 Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 2007 1.55
57 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev 2003 1.55
58 β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science 2014 1.55
59 Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A 2012 1.54
60 Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci 2002 1.51
61 Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 2011 1.51
62 Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res 2005 1.51
63 Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 2004 1.50
64 Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Gastroenterology 2006 1.47
65 Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling. Gastroenterology 2009 1.47
66 Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A 2002 1.44
67 Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J 2004 1.42
68 A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation. Dev Biol 2008 1.42
69 Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. Cancer Res 2002 1.39
70 Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus. Eur J Neurosci 2003 1.39
71 Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 2003 1.37
72 Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol 2009 1.34
73 Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A 2010 1.33
74 Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program. Development 2009 1.31
75 Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 2006 1.31
76 Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice. Biol Reprod 2009 1.31
77 Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 2008 1.27
78 Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest 2014 1.27
79 Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development 2007 1.27
80 Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol 2007 1.26
81 Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 2009 1.26
82 Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J Neurosci 2010 1.26
83 Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. Mol Imaging Biol 2006 1.24
84 β-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma. PLoS Genet 2013 1.24
85 Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene 2002 1.22
86 Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Dev Biol 2006 1.21
87 Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun 2011 1.20
88 Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc Natl Acad Sci U S A 2010 1.19
89 Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol 2007 1.19
90 Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos. Development 2005 1.16
91 Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer Res 2003 1.16
92 Wnt4/β-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 2013 1.16
93 Significance and mechanism of lymph node metastasis in cancer progression. Cancer Res 2011 1.15
94 Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice. J Neurosci 2003 1.14
95 The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. J Pharmacol Exp Ther 2004 1.14
96 Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development 2010 1.13
97 Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression. J Exp Med 2012 1.12
98 Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev Biol 2010 1.12
99 WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development 2012 1.12
100 Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol 2009 1.12
101 Pax6 is essential for lens fiber cell differentiation. Development 2009 1.12
102 Ectodermal Wnt/β-catenin signaling shapes the mouse face. Dev Biol 2010 1.10
103 Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons. Dev Biol 2006 1.09
104 Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol 2003 1.09
105 Sox9 is required for notochord maintenance in mice. Dev Biol 2006 1.09
106 M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol 2004 1.09
107 Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. Development 2008 1.08
108 A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. Clin Cancer Res 2003 1.05
109 The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. Dev Biol 2006 1.04
110 Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci 2009 1.04
111 Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN. PLoS One 2011 1.04
112 The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One 2009 1.03
113 Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Brain Res Mol Brain Res 2005 1.02
114 COX selectivity and animal models for colon cancer. Curr Pharm Des 2002 1.02
115 RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One 2011 1.02
116 Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice. J Pharmacol Exp Ther 2003 1.01
117 Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J Biol Chem 2003 1.01
118 A targeted mutation of Nkd1 impairs mouse spermatogenesis. J Biol Chem 2004 1.01
119 Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem 2007 1.00
120 Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology 2009 0.99
121 Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol 2009 0.99
122 Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses. Biochem Biophys Res Commun 2004 0.99
123 Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. Development 2009 0.99
124 Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas. Lab Invest 2008 0.98
125 Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci 2004 0.98
126 Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development 2012 0.96
127 Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol 2013 0.96
128 Sox9 is required for invagination of the otic placode in mice. Dev Biol 2008 0.94
129 The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res 2005 0.94
130 Cystometric findings in mice lacking muscarinic M2 or M3 receptors. J Urol 2004 0.93
131 β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 2012 0.93
132 Tissue-specific transgenic, conditional knockout and knock-in mice of genes in the canonical Wnt signaling pathway. Methods Mol Biol 2008 0.93
133 β-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice. Dev Biol 2012 0.92
134 Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Dev Biol 2011 0.91
135 Keeping out the bad guys: gateway to cellular target therapy. Cancer Res 2007 0.91
136 Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death. Basic Res Cardiol 2010 0.90
137 Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme. Proc Natl Acad Sci U S A 2010 0.90
138 Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury. J Cell Sci 2003 0.89
139 CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development. Mol Endocrinol 2013 0.89
140 Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. Biol Reprod 2009 0.89
141 CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. Gastroenterology 2009 0.89
142 Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis 2005 0.88
143 Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. Cancer Res 2011 0.88
144 Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci 2004 0.88
145 Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Skelet Muscle 2013 0.87
146 Col1a1-cre mediated activation of β-catenin leads to aberrant dento-alveolar complex formation. Anat Cell Biol 2012 0.86
147 Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice. Am J Physiol Gastrointest Liver Physiol 2005 0.86
148 Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice. Gastroenterology 2003 0.85
149 LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. J Biol Chem 2010 0.85
150 No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. Cancer Res 2002 0.85
151 Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1. Cereb Cortex 2011 0.84
152 Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci 2010 0.84
153 β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pathol 2013 0.84
154 Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors. J Pharmacol Exp Ther 2003 0.84
155 Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. J Immunol 2011 0.83
156 The role of mTORC1 pathway in intestinal tumorigenesis. Cell Cycle 2009 0.83
157 beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One 2010 0.81
158 Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum. J Neurophysiol 2004 0.81
159 Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4. Eur J Pharmacol 2003 0.80
160 β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells. Mol Cell Neurosci 2011 0.79
161 Hypergravity induces expression of cyclooxygenase-2 in the heart vessels. Biochem Biophys Res Commun 2005 0.79
162 The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling. Carcinogenesis 2012 0.78
163 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun 2009 0.77
164 [COX inhibitor, suppression of polyposis, and chemoprevention]. Nihon Yakurigaku Zasshi 2002 0.75