Published in Proc Natl Acad Sci U S A on February 04, 2005
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A random shRNA-encoding library for phenotypic selection and hit-optimization. PLoS One (2008) 0.82
RNA modulators of complex phenotypes in mammalian cells. PLoS One (2009) 0.78
RNA-mediated gene silencing in hematopoietic cells. J Biomed Biotechnol (2006) 0.76
Vector-based siRNA delivery strategies for high-throughput screening of novel target genes. J RNAi Gene Silencing (2005) 0.76
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Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol (2002) 8.31
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
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Expanding small RNA interference. Nat Biotechnol (2002) 3.41
An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene. Nucleic Acids Res (2001) 1.96
Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J Biol Chem (1994) 1.57
Enzymatic production of RNAi libraries from cDNAs. Nat Genet (2004) 1.54
Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nat Genet (2004) 1.40
Validating siRNA using a reporter made from synthetic DNA oligonucleotides. Biochem Biophys Res Commun (2004) 1.14
Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs. Biochem Biophys Res Commun (2003) 1.06
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med (2008) 5.62
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
Adjustment of systematic microarray data biases. Bioinformatics (2004) 5.22
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A (2007) 4.69
Regulatory roles of natural antisense transcripts. Nat Rev Mol Cell Biol (2009) 4.48
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A (2002) 4.20
Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17
Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06
Complex Loci in human and mouse genomes. PLoS Genet (2006) 3.74
High-throughput synthesis of zeolitic imidazolate frameworks and application to CO2 capture. Science (2008) 3.62
The reality of pervasive transcription. PLoS Biol (2011) 3.41
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
The draft genome of a diploid cotton Gossypium raimondii. Nat Genet (2012) 3.18
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res (2008) 3.16
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem (2009) 3.16
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest (2012) 3.14
DNAzyme targeting c-jun suppresses skin cancer growth. Sci Transl Med (2012) 3.09
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol (2012) 3.07
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem (2008) 3.00
The role of parental monitoring in adolescent health outcomes: impact on regimen adherence in youth with type 1 diabetes. J Pediatr Psychol (2007) 2.92
RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Res (2005) 2.84
The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg (2010) 2.78
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol (1985) (2010) 2.74
Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64
Striatal microRNA controls cocaine intake through CREB signalling. Nature (2010) 2.56
A new stage of the nutrition transition in China. Public Health Nutr (2002) 2.52
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res (2005) 2.27
Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res (2004) 2.25
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res (2005) 2.20
Men who have sex with men and human immunodeficiency virus/sexually transmitted disease control in China. Sex Transm Dis (2006) 2.18
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res (2013) 2.12
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab (2009) 2.11
Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol (2010) 2.08
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med (2005) 2.06
TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. J Biol Chem (2011) 2.06
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A (2009) 2.00
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res (2003) 1.99
Risperidone maintenance treatment in schizophrenia: a randomized, controlled trial. Am J Psychiatry (2010) 1.94
Understanding the nutrition transition: measuring rapid dietary changes in transitional countries. Public Health Nutr (2002) 1.93
Age-specific effective doses for pediatric MSCT examinations at a large children's hospital using DLP conversion coefficients: a simple estimation method. Pediatr Radiol (2008) 1.91
Considerations when using the significance analysis of microarrays (SAM) algorithm. BMC Bioinformatics (2005) 1.89
Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year study. Arch Gen Psychiatry (2010) 1.89
Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy. FASEB J (2005) 1.85
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J Clin Invest (2011) 1.84
A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol (2008) 1.80
Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Sci Transl Med (2013) 1.74
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006. Arthritis Rheum (2011) 1.68
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med (2010) 1.64
Three-dimensional anthropometric analysis of the Chinese nose. J Plast Reconstr Aesthet Surg (2010) 1.62
Adult somatic stem cells in the human parasite Schistosoma mansoni. Nature (2013) 1.61
Development of a catheter for combined intravascular ultrasound and photoacoustic imaging. Rev Sci Instrum (2010) 1.61
Diabetes complications: the microRNA perspective. Diabetes (2011) 1.60
Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants. Microbiome (2013) 1.58
Improved and automated prediction of effective siRNA. Biochem Biophys Res Commun (2004) 1.58
Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women's Health Initiative. J Am Coll Cardiol (2013) 1.57
Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States. Arthritis Care Res (Hoboken) (2011) 1.57
Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J Womens Health (Larchmt) (2013) 1.57
A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS One (2008) 1.57
Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study. Arthritis Res Ther (2011) 1.55
Primary spontaneous cerebrospinal fluid rhinorrhea: a symptom of idiopathic intracranial hypertension? J Neurosurg (2011) 1.53
Diagnosing heterogeneous dynamics in single-molecule/particle trajectories with multiscale wavelets. ACS Nano (2013) 1.52
Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction. Neuroimage Clin (2012) 1.52
Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort. Ann Rheum Dis (2011) 1.51
Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease. Leuk Res (2009) 1.51
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol (2010) 1.51
Overexpression of macrophage migration inhibitory factor induces angiogenesis in human breast cancer. Cancer Lett (2008) 1.49
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc Natl Acad Sci U S A (2012) 1.49
Prospects of molecular photoacoustic imaging at 1064 nm wavelength. Opt Lett (2010) 1.48
MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med (2008) 1.48
Pseudo-messenger RNA: phantoms of the transcriptome. PLoS Genet (2006) 1.46
Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate (2011) 1.46
Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends Genet (2012) 1.46
The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther (2009) 1.45
The role of EMT in renal fibrosis. Cell Tissue Res (2011) 1.43
Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians. Diabetes (2004) 1.41
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab (2013) 1.39
Environmentally friendly efficient one-pot esterification of cyclohexane with CuO-promoted sulfated zirconia. J Hazard Mater (2008) 1.39
Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res (2009) 1.39
Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family. J Bacteriol (2011) 1.38
Photoacoustic imaging of clinical metal needles in tissue. J Biomed Opt (2010) 1.38
An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J (2010) 1.36
GNAT-like strategy for polyketide chain initiation. Science (2007) 1.36
Multiple functional groups of varying ratios in metal-organic frameworks. Science (2010) 1.35