Published in Mol Biol Cell on February 09, 2005
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell (2010) 1.90
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One (2008) 1.72
Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int J Biochem Cell Biol (2008) 1.71
Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Res (2009) 1.69
Cell cycle features of primate embryonic stem cells. Stem Cells (2005) 1.64
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell (2010) 1.37
The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One (2009) 1.15
Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle. J Cell Physiol (2009) 1.13
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
The abbreviated pluripotent cell cycle. J Cell Physiol (2013) 1.09
Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming. J Cell Physiol (2010) 1.07
The cell cycle and pluripotency. Biochem J (2013) 1.03
microRNA control of mouse and human pluripotent stem cell behavior. Annu Rev Cell Dev Biol (2013) 1.02
Start and the restriction point. Curr Opin Cell Biol (2013) 1.01
Keeping an eye on retinoblastoma control of human embryonic stem cells. J Cell Biochem (2009) 1.01
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res (2015) 1.01
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol (2011) 1.00
Molecular ties between the cell cycle and differentiation in embryonic stem cells. Proc Natl Acad Sci U S A (2014) 0.99
miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. Cell Rep (2013) 0.99
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun (2016) 0.93
Rb and hematopoiesis: stem cells to anemia. Cell Div (2008) 0.93
Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality. PLoS One (2009) 0.93
Screening of human pluripotent stem cells using CGH and FISH reveals low-grade mosaic aneuploidy and a recurrent amplification of chromosome 1q. Eur J Hum Genet (2012) 0.92
p27(KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouse. J Neurosci (2009) 0.89
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell (2010) 0.88
The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells. PLoS One (2012) 0.88
Exposing hidden dimensions of embryonic stem cell cycle control. Cell Stem Cell (2009) 0.87
Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol (2010) 0.87
Concise Review: Control of Cell Fate Through Cell Cycle and Pluripotency Networks. Stem Cells (2016) 0.86
Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7. Cell Cycle (2016) 0.85
Linking the Cell Cycle to Cell Fate Decisions. Trends Cell Biol (2015) 0.85
Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming. Development (2016) 0.84
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network. Nat Cell Biol (2016) 0.84
Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem (2009) 0.82
A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity. Mol Cell Biol (2008) 0.82
A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proc Natl Acad Sci U S A (2014) 0.82
Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells. Exp Cell Res (2012) 0.81
Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. Dev Dyn (2013) 0.80
Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integr Biol (Camb) (2010) 0.80
Growing an Embryo from a Single Cell: A Hurdle in Animal Life. Cold Spring Harb Perspect Biol (2015) 0.79
Geminin is required for the maintenance of pluripotency. PLoS One (2013) 0.79
Geminin promotes an epithelial-to-mesenchymal transition in an embryonic stem cell model of gastrulation. Stem Cells Dev (2013) 0.78
LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells. PLoS One (2013) 0.77
Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells. Am J Physiol Endocrinol Metab (2013) 0.77
The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency. J Biol Chem (2015) 0.76
The architectural organization of human stem cell cycle regulatory machinery. Curr Pharm Des (2012) 0.76
Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Biol Open (2014) 0.76
Crosstalk between stem cell and cell cycle machineries. Curr Opin Cell Biol (2015) 0.76
Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα. Sci Rep (2017) 0.75
G1 checkpoint establishment in vivo during embryonic liver development. BMC Dev Biol (2014) 0.75
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency. Biomaterials (2016) 0.75
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol (1985) 12.74
Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell (1982) 9.11
Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. J Cell Sci (1983) 8.89
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol (1994) 7.40
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell (1999) 4.94
Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81
Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays (1995) 4.70
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell (2000) 4.48
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell (1994) 4.07
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev (2000) 3.74
Parameters controlling transcriptional activation during early Drosophila development. Cell (1986) 3.62
Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol (1995) 3.41
Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev (1994) 3.10
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
Replication licensing--defining the proliferative state? Trends Cell Biol (2002) 2.91
Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene (1996) 2.83
Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors. J Cell Sci (1999) 2.81
Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell (1997) 2.73
Regulation of the cell cycle during early Xenopus development. Cell (1984) 2.73
Proteolysis and the cell cycle: with this RING I do thee destroy. Curr Opin Genet Dev (2000) 2.58
Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts. Oncogene (1994) 2.46
Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development (1995) 2.43
Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem (1997) 2.40
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell (2000) 2.21
Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene (1998) 2.12
A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J Cell Biol (1997) 2.09
Periodic transcription: a cycle within a cycle. Curr Biol (2003) 2.07
Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J Cell Sci (2002) 2.04
c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol (1998) 1.97
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92
The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J (1999) 1.83
Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase. J Biol Chem (1995) 1.71
E2F-induced S phase requires cyclin E. Genes Dev (1996) 1.71
In vivo regulation of the early embryonic cell cycle in Xenopus. Dev Biol (1996) 1.69
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation. Genes Dev (1995) 1.67
Developmental control of a G1-S transcriptional program in Drosophila. Development (1994) 1.60
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol Cell Biol (1999) 1.58
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol (1999) 1.51
Embryonic stem cells and transgenic mice ubiquitously expressing a tau-tagged green fluorescent protein. Dev Biol (2000) 1.41
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene (2004) 1.35
Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. Proc Natl Acad Sci U S A (1999) 1.34
Cyclin A and B functions in the early Drosophila embryo. Development (1999) 1.20
Mechanisms of cyclin-dependent kinase inactivation by progestins. Mol Cell Biol (1998) 1.20
A role for cyclin E/Cdk2 in the timing of the midblastula transition in Xenopus embryos. Dev Biol (1997) 1.17
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells. Oncogene (1998) 1.15
Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics (1998) 1.13
Reversible programming of pluripotent cell differentiation. J Cell Sci (2000) 1.01
Drosophila embryonic pattern repair: how embryos respond to cyclin E-induced ectopic division. Development (1999) 0.97
Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells. Mol Cell Biol (2000) 0.95
Zebrafish cyclin E regulation during early embryogenesis. Dev Dyn (1996) 0.91
Cell cycle analysis in the mouse EGG-cylinder. Exp Cell Res (1971) 0.89
Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression. J Biol Chem (2001) 0.88
Involvement of pRB-related p107 protein in the inhibition of S phase progression in response to genotoxic stress. J Biol Chem (2001) 0.87
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem (1996) 0.83
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology (2010) 6.40
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res (2010) 4.67
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells (2007) 3.04
Preserving the genetic integrity of human embryonic stem cells. Nat Biotechnol (2005) 3.03
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Cell cycle control of embryonic stem cells. Stem Cell Rev (2005) 2.64
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell (2012) 1.94
Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell (2010) 1.90
Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells. Proc Natl Acad Sci U S A (2011) 1.56
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev (2003) 1.45
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene (2004) 1.35
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol (2009) 1.31
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog (2012) 1.29
Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep (2012) 1.27
Replication timing: a fingerprint for cell identity and pluripotency. PLoS Comput Biol (2011) 1.21
Human motor neuron differentiation from human embryonic stem cells. Stem Cells Dev (2005) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
Directed differentiation of human pluripotent cells to neural crest stem cells. Nat Protoc (2013) 1.04
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev (2013) 1.04
Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells. J Biol Chem (2012) 1.03
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
Xylem ionic relations and salinity tolerance in barley. Plant J (2009) 0.97
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J Biol Chem (2012) 0.97
The response of the maize nitrate transport system to nitrogen demand and supply across the lifecycle. New Phytol (2013) 0.97
Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency. Cell Cycle (2011) 0.94
Glycoproteomic analysis of embryonic stem cells: identification of potential glycobiomarkers using lectin affinity chromatography of glycopeptides. J Proteome Res (2010) 0.93
Transcriptional profiling of initial differentiation events in human embryonic stem cells. Biochem Biophys Res Commun (2004) 0.93
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
The lectin Dolichos biflorus agglutinin recognizes glycan epitopes on the surface of murine embryonic stem cells: a new tool for characterizing pluripotent cells and early differentiation. Stem Cells (2006) 0.91
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res (2009) 0.89
Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem (2013) 0.86
Transcriptional profiling of definitive endoderm derived from human embryonic stem cells. Comput Syst Bioinformatics Conf (2007) 0.86
Efficient generation of alpha(1,3) galactosyltransferase knockout porcine fetal fibroblasts for nuclear transfer. Transgenic Res (2002) 0.85
A comparison of two in vitro maturation media for use with adult porcine oocytes for adult somatic cell nuclear transfer. Cloning Stem Cells (2007) 0.83
Reconciling the different roles of Gsk3β in "naïve" and "primed" pluripotent stem cells. Cell Cycle (2012) 0.83
An efficient method for producing alpha(1,3)-galactosyltransferase gene knockout pigs. Cloning Stem Cells (2004) 0.82
Lectin-functionalized microchannels for characterizing pluripotent cells and early differentiation. Biomicrofluidics (2012) 0.80
To Stretch the Boundary of Secondary Metabolite Production in Plant Cell-Based Bioprocessing: Anthocyanin as a Case Study. J Biomed Biotechnol (2004) 0.79
Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis. BMC Biol (2010) 0.78
Cell-Cycle Control of Developmentally Regulated Transcription Factors Accounts for Heterogeneity in Human Pluripotent Cells. Stem Cell Reports (2014) 0.75
Dangerous to be simplistic about mental health review. Nurs Stand (2006) 0.75
NHS England chief executive: welcome back, Simon. Here's your to-do list. Health Serv J (2014) 0.75