Published in Mol Cell Biol on February 17, 2009
GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci (2009) 2.11
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell (2012) 1.94
Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76
myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation (2010) 1.50
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation. Oncogene (2010) 1.41
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells (2011) 1.22
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One (2009) 1.20
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One (2012) 1.01
Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol Cell Biol (2013) 1.01
Functions of GSK-3 Signaling in Development of the Nervous System. Front Mol Neurosci (2011) 0.99
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling. Development (2013) 0.89
JAK-STAT3 and somatic cell reprogramming. JAKSTAT (2013) 0.88
Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol (2010) 0.87
Protein kinase C-induced early growth response protein-1 binding to SNAIL promoter in epithelial-mesenchymal transition of human embryonic stem cells. Stem Cells Dev (2014) 0.84
Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1. PLoS One (2013) 0.84
Reconciling the different roles of Gsk3β in "naïve" and "primed" pluripotent stem cells. Cell Cycle (2012) 0.83
Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells. Oncogene (2010) 0.81
Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal. PLoS One (2013) 0.81
Short-term serum-free culture reveals that inhibition of Gsk3β induces the tumor-like growth of mouse embryonic stem cells. PLoS One (2011) 0.81
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells. Cell Cycle (2015) 0.80
GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1. Stem Cells Dev (2014) 0.78
Key players in the gene networks guiding ESCs toward mesoderm. J Stem Cells (2009) 0.78
Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells. JAKSTAT (2012) 0.78
Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway. J Cell Physiol (2014) 0.78
Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2. Oncotarget (2015) 0.78
The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells. Stem Cells Int (2016) 0.76
Glycogen Synthase Kinase-3 (GSK-3)-Mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates Repair of Floxuridine-Induced DNA Lesions and Promotes Cell Survival. J Biol Chem (2016) 0.75
Membrane translocation of t-SNARE protein syntaxin-4 abrogates ground-state pluripotency in mouse embryonic stem cells. Sci Rep (2017) 0.75
Glycogen synthase kinase 3β inhibition enhanced proliferation, migration and functional re-endothelialization of endothelial progenitor cells in hypercholesterolemia microenvironment. Exp Biol Med (Maywood) (2015) 0.75
Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal. Acta Naturae (2016) 0.75
Inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) Suppresses the Progression of Esophageal Squamous Cell Carcinoma by Modifying STAT3 Activity. Mol Carcinog (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet (2000) 21.52
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev (1998) 12.55
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
How is pluripotency determined and maintained? Development (2007) 6.92
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science (1997) 4.99
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J (1999) 4.55
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell (2007) 4.39
The myc oncogene: MarvelouslY Complex. Adv Cancer Res (2002) 3.68
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem (2004) 2.82
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene (2006) 2.42
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta. J Biol Chem (2001) 1.90
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci U S A (2004) 1.89
Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem (2007) 1.56
Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem Soc Trans (2005) 1.50
Identification of the Axin and Frat binding region of glycogen synthase kinase-3. J Biol Chem (2001) 1.49
Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis. J Biol Chem (2007) 1.46
Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-beta-catenin Pathway. J Biol Chem (2003) 1.33
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. J Biol Chem (2002) 1.25
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex. J Biol Chem (2003) 1.13
Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3. Stem Cells (2007) 1.11
Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts. Aging Cell (2004) 0.98
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology (2010) 6.40
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res (2010) 4.67
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells (2007) 3.04
Preserving the genetic integrity of human embryonic stem cells. Nat Biotechnol (2005) 3.03
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Cell cycle control of embryonic stem cells. Stem Cell Rev (2005) 2.64
Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol Biol Cell (2005) 2.00
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell (2012) 1.94
Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell (2010) 1.90
Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells. Proc Natl Acad Sci U S A (2011) 1.56
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev (2003) 1.45
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene (2004) 1.35
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog (2012) 1.29
Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep (2012) 1.27
Replication timing: a fingerprint for cell identity and pluripotency. PLoS Comput Biol (2011) 1.21
Human motor neuron differentiation from human embryonic stem cells. Stem Cells Dev (2005) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
Directed differentiation of human pluripotent cells to neural crest stem cells. Nat Protoc (2013) 1.04
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev (2013) 1.04
Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells. J Biol Chem (2012) 1.03
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J Biol Chem (2012) 0.97
Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency. Cell Cycle (2011) 0.94
Glycoproteomic analysis of embryonic stem cells: identification of potential glycobiomarkers using lectin affinity chromatography of glycopeptides. J Proteome Res (2010) 0.93
Transcriptional profiling of initial differentiation events in human embryonic stem cells. Biochem Biophys Res Commun (2004) 0.93
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
The lectin Dolichos biflorus agglutinin recognizes glycan epitopes on the surface of murine embryonic stem cells: a new tool for characterizing pluripotent cells and early differentiation. Stem Cells (2006) 0.91
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res (2009) 0.89
Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem (2013) 0.86
Transcriptional profiling of definitive endoderm derived from human embryonic stem cells. Comput Syst Bioinformatics Conf (2007) 0.86
Reconciling the different roles of Gsk3β in "naïve" and "primed" pluripotent stem cells. Cell Cycle (2012) 0.83
Lectin-functionalized microchannels for characterizing pluripotent cells and early differentiation. Biomicrofluidics (2012) 0.80
Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis. BMC Biol (2010) 0.78
NHS England chief executive: welcome back, Simon. Here's your to-do list. Health Serv J (2014) 0.75
Cell-Cycle Control of Developmentally Regulated Transcription Factors Accounts for Heterogeneity in Human Pluripotent Cells. Stem Cell Reports (2014) 0.75