Published in Cell Stem Cell on September 03, 2010
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 2.09
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell (2012) 1.94
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell (2013) 1.91
Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning. Cell (2012) 1.76
The human airway epithelial basal cell transcriptome. PLoS One (2011) 1.69
Induced pluripotency and oncogenic transformation are related processes. Stem Cells Dev (2012) 1.64
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell (2016) 1.59
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
A unique role of cohesin-SA1 in gene regulation and development. EMBO J (2012) 1.38
Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. Mol Cell Biol (2011) 1.28
MicroRNAs in embryonic stem cell function and fate. Genes Dev (2010) 1.27
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell (2014) 1.20
microRNAs modulate iPS cell generation. RNA (2011) 1.19
The abbreviated pluripotent cell cycle. J Cell Physiol (2013) 1.09
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev (2013) 1.04
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med (2014) 1.03
The cell cycle and pluripotency. Biochem J (2013) 1.03
Inducing iPSCs to escape the dish. Cell Stem Cell (2011) 1.03
A statin-regulated microRNA represses human c-Myc expression and function. EMBO Mol Med (2012) 1.03
microRNA control of mouse and human pluripotent stem cell behavior. Annu Rev Cell Dev Biol (2013) 1.02
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One (2012) 1.01
Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics Chromatin (2011) 1.00
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
LIF-dependent signaling: new pieces in the Lego. Stem Cell Rev (2012) 0.98
A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nat Commun (2013) 0.97
microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1. EMBO J (2013) 0.94
Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency. Cell Cycle (2011) 0.94
MicroRNAs as novel regulators of stem cell fate. World J Stem Cells (2013) 0.94
Qualitative network modeling of the Myc-p53 control system of cell proliferation and differentiation. Biophys J (2011) 0.93
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
Metabolic Reprogramming of Stem Cell Epigenetics. Cell Stem Cell (2015) 0.91
Nuclear reprogramming strategy modulates differentiation potential of induced pluripotent stem cells. J Cardiovasc Transl Res (2011) 0.90
The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells. J Biol Chem (2012) 0.90
Myc and max genome-wide binding sites analysis links the Myc regulatory network with the polycomb and the core pluripotency networks in mouse embryonic stem cells. PLoS One (2014) 0.89
Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis. PLoS One (2012) 0.88
MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harb Perspect Med (2014) 0.88
Regulation of embryonic stem cell pluripotency by heat shock protein 90. Stem Cells (2012) 0.87
Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells. PLoS One (2012) 0.87
Concise Review: Control of Cell Fate Through Cell Cycle and Pluripotency Networks. Stem Cells (2016) 0.86
Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell (2016) 0.86
Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn. Oncogene (2012) 0.86
TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues. Nucleic Acids Res (2015) 0.85
OSKM Induce Extraembryonic Endoderm Stem Cells in Parallel to Induced Pluripotent Stem Cells. Stem Cell Reports (2016) 0.84
Embryonic stem cell miRNAs and their roles in development and disease. Semin Cancer Biol (2012) 0.84
Epigenetic memory in the context of nuclear reprogramming and cancer. Brief Funct Genomics (2013) 0.84
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst (2012) 0.84
MYC and the control of DNA replication. Cold Spring Harb Perspect Med (2014) 0.84
Regeneration of Hair Cells: Making Sense of All the Noise. Pharmaceuticals (Basel) (2011) 0.83
Reconciling the different roles of Gsk3β in "naïve" and "primed" pluripotent stem cells. Cell Cycle (2012) 0.83
Understanding the molecular circuitry of cell lineage specification in the early mouse embryo. Genes (Basel) (2011) 0.79
Destabilization of pluripotency in the absence of Mad2l2. Cell Cycle (2015) 0.79
Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts. Stem Cells Int (2012) 0.78
Telomerase reverse transcriptase regulates microRNAs. Int J Mol Sci (2015) 0.77
V-myc immortalizes human neural stem cells in the absence of pluripotency-associated traits. PLoS One (2015) 0.76
Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs. PLoS One (2013) 0.76
Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells. J Clin Med (2015) 0.76
Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. Biochem Biophys Res Commun (2013) 0.76
Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells. Stem Cells Dev (2015) 0.76
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
Utilizing FUCCI reporters to understand pluripotent stem cell biology. Methods (2015) 0.75
The MYCN Protein in Health and Disease. Genes (Basel) (2017) 0.75
Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int (2015) 0.75
A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun (2016) 0.75
The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evol Biol (2016) 0.75
Effects of high-mobility group a protein application on canine adipose-derived mesenchymal stem cells in vitro. Vet Med Int (2012) 0.75
Discovery of a Family of Genomic Sequences Which Interact Specifically with the c-MYC Promoter to Regulate c-MYC Expression. PLoS One (2016) 0.75
MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux. Cell Stem Cell (2017) 0.75
The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance. Genes (Basel) (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Reflecting on 25 years with MYC. Nat Rev Cancer (2008) 7.44
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol (2009) 5.14
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev (1998) 4.72
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells (2007) 4.04
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev (2002) 3.71
Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One (2008) 3.68
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev (2000) 3.62
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31
The transcription factor GATA6 is essential for early extraembryonic development. Development (1999) 3.19
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev (2002) 3.16
Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev (2002) 3.12
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene (1996) 2.83
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One (2008) 2.51
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A (2008) 2.42
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol (2008) 2.29
MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A (2008) 2.24
Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr Biol (1996) 2.22
Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol Biol Cell (2005) 2.00
Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Cell Biol (2004) 1.98
Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci U S A (2005) 1.85
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol Cell Biol (2006) 1.69
High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Mol Cell Biol (1990) 1.43
Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation. J Cell Sci (2004) 1.38
Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev (2010) 1.23
Dissecting the molecular hierarchy for mesendoderm differentiation through a combination of embryonic stem cell culture and RNA interference. Stem Cells (2007) 1.16
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology (2010) 6.40
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res (2010) 4.67
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene (2002) 3.06
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells (2007) 3.04
Preserving the genetic integrity of human embryonic stem cells. Nat Biotechnol (2005) 3.03
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Cell cycle control of embryonic stem cells. Stem Cell Rev (2005) 2.64
Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol Biol Cell (2005) 2.00
Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell (2012) 1.94
Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells. Proc Natl Acad Sci U S A (2011) 1.56
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev (2003) 1.45
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene (2004) 1.35
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol (2009) 1.31
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog (2012) 1.29
Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep (2012) 1.27
Replication timing: a fingerprint for cell identity and pluripotency. PLoS Comput Biol (2011) 1.21
Human motor neuron differentiation from human embryonic stem cells. Stem Cells Dev (2005) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Mol Cell Biol (2007) 1.09
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
Directed differentiation of human pluripotent cells to neural crest stem cells. Nat Protoc (2013) 1.04
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev (2013) 1.04
Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells. J Biol Chem (2012) 1.03
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J Biol Chem (2012) 0.97
Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency. Cell Cycle (2011) 0.94
Glycoproteomic analysis of embryonic stem cells: identification of potential glycobiomarkers using lectin affinity chromatography of glycopeptides. J Proteome Res (2010) 0.93
Transcriptional profiling of initial differentiation events in human embryonic stem cells. Biochem Biophys Res Commun (2004) 0.93
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
The lectin Dolichos biflorus agglutinin recognizes glycan epitopes on the surface of murine embryonic stem cells: a new tool for characterizing pluripotent cells and early differentiation. Stem Cells (2006) 0.91
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res (2009) 0.89
Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem (2013) 0.86
Transcriptional profiling of definitive endoderm derived from human embryonic stem cells. Comput Syst Bioinformatics Conf (2007) 0.86
Reconciling the different roles of Gsk3β in "naïve" and "primed" pluripotent stem cells. Cell Cycle (2012) 0.83
Stem cell plasticity, beyond alchemy. Int J Hematol (2004) 0.82
Lectin-functionalized microchannels for characterizing pluripotent cells and early differentiation. Biomicrofluidics (2012) 0.80
Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis. BMC Biol (2010) 0.78
NHS England chief executive: welcome back, Simon. Here's your to-do list. Health Serv J (2014) 0.75
Cell-Cycle Control of Developmentally Regulated Transcription Factors Accounts for Heterogeneity in Human Pluripotent Cells. Stem Cell Reports (2014) 0.75