PubRank

Eleftheria Zeggini

Author PubWeight™ 312.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007 37.88
2 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
3 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
4 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010 16.96
5 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
6 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007 12.62
7 Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009 12.44
8 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010 12.27
9 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012 11.09
10 Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008 10.85
11 An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol 2010 10.54
12 A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 2007 6.87
13 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
14 Rare variant association analysis methods for complex traits. Annu Rev Genet 2010 5.59
15 Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet 2004 4.76
16 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008 4.57
17 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014 4.13
18 The UK10K project identifies rare variants in health and disease. Nature 2015 3.89
19 Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006 3.79
20 Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008 3.76
21 Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006 3.75
22 Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes 2006 3.51
23 Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012 3.48
24 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
25 Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes 2009 2.85
26 Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007 2.73
27 Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009 2.60
28 Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy. Trends Pharmacol Sci 2007 2.09
29 Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol 2011 2.00
30 Replication in genome-wide association studies. Stat Sci 2009 1.89
31 Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis 2010 1.75
32 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
33 Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum 2002 1.66
34 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2008 1.64
35 Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis 2012 1.62
36 Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol 2009 1.60
37 A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet 2011 1.60
38 Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 2009 1.58
39 A combined functional annotation score for non-synonymous variants. Hum Hered 2012 1.37
40 Synthetic associations in the context of genome-wide association scan signals. Hum Mol Genet 2010 1.36
41 Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes 2008 1.33
42 Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 2004 1.29
43 Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One 2009 1.28
44 Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet 2010 1.26
45 CCRaVAT and QuTie-enabling analysis of rare variants in large-scale case control and quantitative trait association studies. BMC Bioinformatics 2010 1.26
46 Finding common susceptibility variants for complex disease: past, present and future. Brief Funct Genomic Proteomic 2009 1.20
47 A powerful approach to sub-phenotype analysis in population-based genetic association studies. Genet Epidemiol 2010 1.16
48 A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum 2004 1.16
49 In search of low-frequency and rare variants affecting complex traits. Hum Mol Genet 2013 1.14
50 Genome-wide association analysis of imputed rare variants: application to seven common complex diseases. Genet Epidemiol 2012 1.06
51 Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One 2010 1.05
52 ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data. Hum Hered 2012 1.05
53 Estimating genome-wide significance for whole-genome sequencing studies. Genet Epidemiol 2014 1.04
54 The effect of next-generation sequencing technology on complex trait research. Eur J Clin Invest 2010 1.04
55 The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet 2011 1.04
56 GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs. BMC Bioinformatics 2009 1.03
57 Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol 2014 1.00
58 Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits. J Clin Endocrinol Metab 2005 0.96
59 The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults. Diabetes 2006 0.96
60 Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes 2009 0.95
61 Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes 2006 0.95
62 Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 2007 0.93
63 Genome-wide association scan allowing for epistasis in type 2 diabetes. Ann Hum Genet 2010 0.93
64 The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Ann Rheum Dis 2013 0.92
65 Rare and low frequency variant stratification in the UK population: description and impact on association tests. PLoS One 2012 0.91
66 An evaluation of different target enrichment methods in pooled sequencing designs for complex disease association studies. PLoS One 2011 0.91
67 Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. BMC Med Genet 2010 0.90
68 Examining the statistical properties of fine-scale mapping in large-scale association studies. Genet Epidemiol 2008 0.90
69 Advances in osteoarthritis genetics. J Med Genet 2013 0.89
70 Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet 2012 0.88
71 Identification of novel putative rheumatoid arthritis susceptibility genes via analysis of rare variants. BMC Proc 2009 0.88
72 Sex-specific differences in effect size estimates at established complex trait loci. Int J Epidemiol 2012 0.87
73 Using population isolates in genetic association studies. Brief Funct Genomics 2014 0.87
74 No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis 2012 0.86
75 Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p. Arthritis Rheum 2004 0.86
76 Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis. Hum Genet 2010 0.85
77 Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. Am J Med Genet B Neuropsychiatr Genet 2012 0.85
78 Will the real disease gene please stand up? BMC Genet 2005 0.84
79 Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes 2007 0.84
80 Genetics of type 2 diabetes. Curr Diab Rep 2006 0.84
81 Ranking of genome-wide association scan signals by different measures. Int J Epidemiol 2009 0.84
82 Testing for rare variant associations in complex diseases. Genome Med 2011 0.84
83 Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study. Ann Hum Genet 2013 0.83
84 An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity. Eur J Hum Genet 2012 0.83
85 Defining the power limits of genome-wide association scan meta-analyses. Genet Epidemiol 2011 0.82
86 Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels. Eur J Hum Genet 2007 0.81
87 Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia. J Hum Genet 2007 0.81
88 Imputation of rare variants in next-generation association studies. Hum Hered 2013 0.78
89 Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. J Rheumatol 2004 0.78
90 Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. Hum Immunol 2009 0.78
91 Erratum: Whole-genome sequence-based analysis of thyroid function. Nat Commun 2015 0.77
92 MCP-1 gene haplotype association in biopsy proven giant cell arteritis. J Rheumatol 2005 0.77
93 Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. J Rheumatol 2002 0.76
94 Rare variant association testing for next-generation sequencing data via hierarchical clustering. Hum Hered 2013 0.76
95 Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One 2012 0.75
96 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
97 Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure. BMC Genet 2003 0.75
98 New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet 2017 0.75
99 Do genome-wide association scans have potential for translation? Clin Chem Lab Med 2011 0.75
100 Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nat Commun 2015 0.75