Published in Ann Hum Genet on January 24, 2013
Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective. Mol Genet Genomics (2015) 0.90
Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants. Nat Commun (2014) 0.88
FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis. PLoS One (2013) 0.84
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial. Cardiovasc Diabetol (2014) 0.81
FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet. Mol Psychiatry (2014) 0.79
Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs. Genet Sel Evol (2014) 0.78
Progressive influence of body mass index-associated genetic markers in rural Gambians. J Med Genet (2015) 0.76
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ (2000) 56.80
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics (2007) 8.03
Prevalence of overweight among children in Europe. Obes Rev (2003) 3.21
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr (2009) 2.74
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med (2007) 2.34
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes (2010) 1.70
Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans. Obesity (Silver Spring) (2011) 1.21
Epidemiological survey for the prevalence of overweight and abdominal obesity in Greek adolescents. Obesity (Silver Spring) (2008) 1.19
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol (2010) 10.54
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Rare variant association analysis methods for complex traits. Annu Rev Genet (2010) 5.59
Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet (2004) 4.76
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes (2006) 3.79
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med (2006) 3.75
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes (2006) 3.51
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes (2007) 2.73
Genome-wide association studies in type 2 diabetes. Curr Diab Rep (2009) 2.60
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A (2004) 2.16
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy. Trends Pharmacol Sci (2007) 2.09
Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol (2011) 2.00
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Replication in genome-wide association studies. Stat Sci (2009) 1.89
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum (2002) 1.66
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes (2008) 1.64
Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis (2012) 1.62
Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation. Proc Natl Acad Sci U S A (2004) 1.61
Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol (2009) 1.60
A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet (2011) 1.60
Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes (2009) 1.58
Extreme context specificity in differential allelic expression. Hum Mol Genet (2007) 1.47
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet (2008) 1.45
Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs. Arthritis Rheum (2002) 1.41
A combined functional annotation score for non-synonymous variants. Hum Hered (2012) 1.37
Synthetic associations in the context of genome-wide association scan signals. Hum Mol Genet (2010) 1.36
Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis Rheum (2009) 1.34
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes (2008) 1.33
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes (2011) 1.31
Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab (2004) 1.29
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One (2009) 1.28
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet (2010) 1.26
CCRaVAT and QuTie-enabling analysis of rare variants in large-scale case control and quantitative trait association studies. BMC Bioinformatics (2010) 1.26
Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Hum Mol Genet (2002) 1.24
Finding common susceptibility variants for complex disease: past, present and future. Brief Funct Genomic Proteomic (2009) 1.20
A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum (2004) 1.16
A powerful approach to sub-phenotype analysis in population-based genetic association studies. Genet Epidemiol (2010) 1.16
In search of low-frequency and rare variants affecting complex traits. Hum Mol Genet (2013) 1.14
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes (2011) 1.13
Association between family divorce and children's BMI and meal patterns: the GENDAI Study. Obesity (Silver Spring) (2008) 1.07
Genome-wide association analysis of imputed rare variants: application to seven common complex diseases. Genet Epidemiol (2012) 1.06
Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One (2010) 1.05
ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data. Hum Hered (2012) 1.05
Estimating genome-wide significance for whole-genome sequencing studies. Genet Epidemiol (2014) 1.04
The effect of next-generation sequencing technology on complex trait research. Eur J Clin Invest (2010) 1.04
The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet (2011) 1.04
GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs. BMC Bioinformatics (2009) 1.03
Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp Gerontol (2007) 1.02
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol (2014) 1.00
The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults. Diabetes (2006) 0.96
Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits. J Clin Endocrinol Metab (2005) 0.96
Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. BMC Med Genet (2009) 0.96
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes (2006) 0.95
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes (2009) 0.95
Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6. Eur J Hum Genet (2002) 0.93