PubRank

Luke W Guddat

Author PubWeight™ 41.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The catalytic mechanisms of binuclear metallohydrolases. Chem Rev 2006 1.50
2 Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiol Biochem 2008 1.45
3 Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J Mol Biol 2002 1.24
4 Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proc Natl Acad Sci U S A 2006 1.21
5 Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem 2002 1.16
6 Structure-activity relationships for a new family of sulfonylurea herbicides. J Comput Aided Mol Des 2005 1.13
7 Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry 2005 1.12
8 Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proc Natl Acad Sci U S A 2004 1.12
9 The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem 2003 1.08
10 Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment. Structure 2002 1.05
11 Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data. Eur J Biochem 2003 0.95
12 Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallogr D Biol Crystallogr 2002 0.94
13 The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci 2005 0.93
14 Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Struct Biol 2008 0.91
15 Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction. Acc Chem Res 2012 0.90
16 Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol Pharmacol 2013 0.89
17 Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem 2009 0.88
18 Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J 2009 0.87
19 Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta 2007 0.87
20 Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. J Mol Biol 2009 0.84
21 Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J Am Chem Soc 2008 0.84
22 Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Arch Biochem Biophys 2004 0.83
23 Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. J Med Chem 2013 0.83
24 Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. FEBS J 2005 0.83
25 The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. J Mol Biol 2005 0.83
26 Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. J Inorg Biochem 2011 0.83
27 Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J Mol Biol 2012 0.81
28 Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem 2012 0.81
29 Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS J 2009 0.80
30 Penicillin inhibitors of purple acid phosphatase. Bioorg Med Chem Lett 2012 0.79
31 Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem Biol Drug Des 2012 0.78
32 Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. Mol Biochem Parasitol 2010 0.78
33 The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochem J 2010 0.78
34 Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallogr D Biol Crystallogr 2004 0.78
35 Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem 2006 0.78
36 Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. J Med Chem 2014 0.78
37 Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? BMC Res Notes 2008 0.77
38 6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs. Curr Top Med Chem 2011 0.77
39 Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorg Med Chem 2011 0.77
40 Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem 2011 0.77
41 Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem 2012 0.77
42 Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorg Med Chem Lett 2008 0.77
43 Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. J Med Chem 2013 0.77
44 The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One 2013 0.76
45 Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Org Biomol Chem 2015 0.76
46 Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.75
47 A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorg Med Chem Lett 2012 0.75
48 Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem 2009 0.75
49 Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. J Agric Food Chem 2011 0.75
50 Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. J Biol Inorg Chem 2014 0.75
51 The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Eur J Med Chem 2013 0.75