Published in Annu Rev Physiol on January 01, 2005
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch (2009) 2.20
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A (2007) 2.17
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res (2009) 1.97
Expression and function of epithelial anoctamins. J Biol Chem (2010) 1.95
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev (2011) 1.67
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells. J Biol Chem (2011) 1.55
Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. Am J Physiol Cell Physiol (2008) 1.49
Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? Pflugers Arch (2007) 1.47
Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. PLoS Biol (2011) 1.45
The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol (2008) 1.40
Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Anoctamins. Pflugers Arch (2011) 1.29
Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line. Am J Physiol Cell Physiol (2008) 1.28
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A (2012) 1.17
Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol (2009) 1.16
cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways. J Clin Invest (2010) 1.15
Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. J Biol Chem (2008) 1.11
Tissue engineering: state of the art in oral rehabilitation. J Oral Rehabil (2009) 1.10
Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands. J Physiol (2007) 1.09
Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. J Biol Chem (2009) 1.04
Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. Gastroenterology (2011) 1.02
Ca2+-activated Cl- channels at a glance. J Cell Sci (2012) 1.01
A mathematical model of fluid secretion from a parotid acinar cell. J Theor Biol (2007) 1.01
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol (2006) 1.01
Gene delivery in salivary glands: from the bench to the clinic. Biochim Biophys Acta (2011) 0.98
Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland. Am J Physiol Cell Physiol (2008) 0.95
Elevated incidence of dental caries in a mouse model of cystic fibrosis. PLoS One (2011) 0.95
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol (2008) 0.94
Rat salivary gland ligation causes reversible secretory hypofunction. Acta Physiol (Oxf) (2007) 0.94
Tight junctions in salivary epithelium. J Biomed Biotechnol (2010) 0.93
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. J Biol Chem (2008) 0.92
Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A (2013) 0.92
Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cells. J Physiol (2007) 0.92
Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem (2010) 0.91
AQP and the control of fluid transport in a salivary gland. J Membr Biol (2006) 0.91
Polarization of calcium signaling and fluid secretion in salivary gland cells. Curr Med Chem (2012) 0.91
Rat parotid gland cell differentiation in three-dimensional culture. Tissue Eng Part C Methods (2010) 0.90
Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1. J Cell Sci (2012) 0.90
Regulation and identification of Na,K-ATPase alpha1 subunit phosphorylation in rat parotid acinar cells. J Biol Chem (2010) 0.89
Dissection of calcium signaling events in exocrine secretion. Neurochem Res (2011) 0.89
HCO3(-) secretion by murine nasal submucosal gland serous acinar cells during Ca2+-stimulated fluid secretion. J Gen Physiol (2008) 0.88
A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands. J Membr Biol (2008) 0.88
IRBIT: it is everywhere. Neurochem Res (2010) 0.88
Phosphorylation state of the Na+-K+-Cl- cotransporter (NKCC1) in the gills of Atlantic killifish (Fundulus heteroclitus) during acclimation to water of varying salinity. J Exp Biol (2010) 0.87
Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling. J Oral Pathol Med (2012) 0.87
Ca²⁺ signaling and regulation of fluid secretion in salivary gland acinar cells. Cell Calcium (2014) 0.87
Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. Am J Physiol Cell Physiol (2008) 0.87
Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J Gen Physiol (2012) 0.87
Anoctamin 1 mediates thermal pain as a heat sensor. Curr Neuropharmacol (2013) 0.86
P2X7 receptor activation induces inflammatory responses in salivary gland epithelium. Am J Physiol Cell Physiol (2012) 0.86
Na+ modulates anion permeation and block of P2X7 receptors from mouse parotid glands. J Membr Biol (2008) 0.85
The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells. J Anat (2006) 0.85
A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A (2015) 0.85
Calcium signalling in salivary gland physiology and dysfunction. J Physiol (2015) 0.85
Homeostasis of the apical plasma membrane during regulated exocytosis in the salivary glands of live rodents. Bioarchitecture (2011) 0.85
Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated by extracellular Cl-. J Biol Chem (2011) 0.85
Salivary Hsp72 does not track exercise stress and caffeine-stimulated plasma Hsp72 responses in humans. Cell Stress Chaperones (2010) 0.85
Why mouse airway submucosal gland serous cells do not secrete fluid in response to cAMP stimulation. J Biol Chem (2012) 0.85
Age and gender related differences in human parotid gland gene expression. Arch Oral Biol (2008) 0.85
Role of calcium and PKC in salivary mucous cell exocrine secretion. J Dent Res (2011) 0.84
Transepithelial bicarbonate secretion: lessons from the pancreas. Cold Spring Harb Perspect Med (2012) 0.84
Aquaporins in Salivary Glands: From Basic Research to Clinical Applications. Int J Mol Sci (2016) 0.84
Pancreatic and biliary secretion are both altered in cystic fibrosis pigs. Am J Physiol Gastrointest Liver Physiol (2012) 0.84
Gene therapy: design and prospects for craniofacial regeneration. J Dent Res (2009) 0.83
Effect of cell swelling on ER/PM junctional interactions and channel assembly involved in SOCE. Cell Calcium (2010) 0.83
Mechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel. Channels (Austin) (2009) 0.82
Ca²⁺-dependent K⁺ channels in exocrine salivary glands. Cell Calcium (2014) 0.82
Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. Cell Calcium (2010) 0.81
IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep (2015) 0.81
Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva. Histochem Cell Biol (2005) 0.81
The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel. Biochim Biophys Acta (2014) 0.81
Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland. Int J Oral Sci (2013) 0.81
Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. J Biol Chem (2015) 0.81
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation. J Physiol (2015) 0.81
Functional differences in the acinar cells of the murine major salivary glands. J Dent Res (2015) 0.80
Mechanism and synergism in epithelial fluid and electrolyte secretion. Pflugers Arch (2013) 0.80
Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice. Arthritis Rheum (2013) 0.80
Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B. J Physiol (2015) 0.80
Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Mol Pain (2015) 0.80
Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium. J Mol Histol (2016) 0.78
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction. Am J Physiol Cell Physiol (2016) 0.78
Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am J Physiol Gastrointest Liver Physiol (2011) 0.78
Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One (2013) 0.78
Developing pressures: fluid forces driving morphogenesis. Curr Opin Genet Dev (2015) 0.78
Multiscale modelling of saliva secretion. Math Biosci (2014) 0.78
Matriptase deletion initiates a Sjögren's syndrome-like disease in mice. PLoS One (2014) 0.78
The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells. Int J Cell Biol (2012) 0.78
Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia. J Histochem Cytochem (2010) 0.78
Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice. Biol Open (2015) 0.78
MCMC estimation of Markov models for ion channels. Biophys J (2011) 1.25
Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons. J Physiol (2002) 1.25
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10
Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands. J Physiol (2007) 1.09
A kinetic model for type I and II IP3R accounting for mode changes. Biophys J (2012) 1.08
External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter. J Gen Physiol (2003) 1.07
The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol Pharmacol (2011) 1.03
Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem (2006) 1.02
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol (2006) 1.01
Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol (2007) 1.00
Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels. J Physiol (2003) 0.98
Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol (2002) 0.98
Selectivity filter gating in large-conductance Ca(2+)-activated K+ channels. J Gen Physiol (2012) 0.98
Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland. Am J Physiol Cell Physiol (2008) 0.95
Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene. J Physiol (2002) 0.94
The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. Am J Physiol Cell Physiol (2009) 0.86
Ca2+-activated K channels in parotid acinar cells: The functional basis for the hyperpolarized activation of BK channels. Channels (Austin) (2010) 0.85
Two stable, conducting conformations of the selectivity filter in Shaker K+ channels. J Gen Physiol (2005) 0.85
Mechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel. Channels (Austin) (2009) 0.82
Chloride channels in the small intestinal cell line IEC-18. J Cell Physiol (2005) 0.80
Pharmacology and surface electrostatics of the K channel outer pore vestibule. J Membr Biol (2007) 0.75
Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃. Channels (Austin) (2012) 0.75