Published in J Physiol on June 19, 2008
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells. J Biol Chem (2011) 1.55
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50
The SLC26 gene family of anion transporters and channels. Mol Aspects Med (2013) 1.50
American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41
Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest (2010) 1.29
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Physiology of epithelial chloride and fluid secretion. Cold Spring Harb Perspect Med (2012) 1.16
Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression. Am J Physiol Renal Physiol (2009) 1.10
Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression. PLoS One (2010) 1.09
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis. Exp Physiol (2010) 1.07
Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters. J Gen Physiol (2011) 1.05
STAS domain structure and function. Cell Physiol Biochem (2011) 1.00
Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model. J Neurosci (2010) 1.00
Role of pendrin in iodide balance: going with the flow. Am J Physiol Renal Physiol (2009) 0.93
cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism. Cell Calcium (2014) 0.88
Pendrin localizes to the adrenal medulla and modulates catecholamine release. Am J Physiol Endocrinol Metab (2015) 0.87
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases. Mediators Inflamm (2015) 0.87
Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated by extracellular Cl-. J Biol Chem (2011) 0.85
Transepithelial bicarbonate secretion: lessons from the pancreas. Cold Spring Harb Perspect Med (2012) 0.84
Identification of allelic variants of pendrin (SLC26A4) with loss and gain of function. Cell Physiol Biochem (2011) 0.84
Thyroid iodide efflux: a team effort? J Physiol (2011) 0.83
TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells. Endocrinology (2011) 0.82
CFTR-SLC26 transporter interactions in epithelia. Biophys Rev (2012) 0.82
SLC4A transporters. Curr Top Membr (2012) 0.82
Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem (2011) 0.81
PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport. Cell Physiol Biochem (2012) 0.81
Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J (2016) 0.80
A quantitative analysis of electrolyte exchange in the salivary duct. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
Mechanism and synergism in epithelial fluid and electrolyte secretion. Pflugers Arch (2013) 0.80
Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. Mol Hum Reprod (2014) 0.79
Transcriptional regulation of the pendrin gene. Cell Physiol Biochem (2011) 0.78
The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol (2011) 0.78
KCNJ10 may not be a contributor to nonsyndromic enlargement of vestibular aqueduct (NSEVA) in Chinese subjects. PLoS One (2014) 0.78
The role of pendrin in blood pressure regulation. Am J Physiol Renal Physiol (2015) 0.78
Integration of human and mouse genetics reveals pendrin function in hearing and deafness. Cell Physiol Biochem (2011) 0.77
Differences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and mice. PLoS One (2013) 0.77
Functional characterization of pendrin mutations found in the Israeli and Palestinian populations. Cell Physiol Biochem (2011) 0.77
Pendrin gene ablation alters ENaC subcellular distribution and open probability. Am J Physiol Renal Physiol (2015) 0.76
Iodide excess regulates its own efflux: a possible involvement of pendrin. Am J Physiol Cell Physiol (2016) 0.76
The multiple roles of pendrin in the kidney. Nephrol Dial Transplant (2014) 0.75
SLC26A4 gene polymorphism and late-onset Alzheimer's disease in a Han Chinese population from Qingdao, China. Neural Regen Res (2013) 0.75
Computational modelling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Sodium-bicarbonate cotransporter NBCn1/Slc4a7 inhibits NH4Cl-mediated inward current in Xenopus oocytes. Exp Physiol (2011) 0.75
The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet (1997) 4.43
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu Rev Physiol (2005) 2.94
The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet (1999) 2.32
Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol (2002) 2.14
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. Am J Physiol Renal Physiol (2001) 2.08
Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. Am J Physiol Renal Physiol (2007) 1.83
Mechanisms of bicarbonate secretion in the pancreatic duct. Annu Rev Physiol (2005) 1.80
The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76
Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology (1988) 1.75
Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem (2002) 1.73
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer (2006) 1.66
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Radioactive iodine and the salivary glands. Thyroid (2003) 1.55
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem (2004) 1.22
Membrane-specific regulation of Cl- channels by purinergic receptors in rat submandibular gland acinar and duct cells. J Biol Chem (1997) 1.21
Recent advances in our understanding of intercalated cells. Curr Opin Nephrol Hypertens (2005) 1.15
Effect of vasoactive intestinal peptide, bombesin and substance P on fluid secretion by isolated rat pancreatic ducts. J Physiol (1990) 1.10
Specificity and regulation of renal sulfate transporters. Annu Rev Physiol (2007) 1.09
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Sodium/iodide-symporter: distribution in different mammals and role in entero-thyroid circulation of iodide. Acta Physiol Scand (2002) 0.97
Mechanism of iodide/chloride exchange by pendrin. Endocrinology (2004) 0.93
Characterization of the adenosinetriphosphatase and transport activities of purified cystic fibrosis transmembrane conductance regulator. Biochemistry (2004) 0.85
The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents. Eur J Endocrinol (2005) 0.85
Chronic pancreatitis and maldigestion. Semin Gastrointest Dis (2002) 0.83
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest (2010) 2.28
Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms? Hum Mutat (2009) 2.25
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology (2005) 2.10
TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. Am J Physiol Heart Circ Physiol (2007) 1.81
The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model. BMC Med (2004) 1.74
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology (2004) 1.72
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69
Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism. Am J Physiol Renal Physiol (2006) 1.59
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am J Pathol (2008) 1.51
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47
Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium (2007) 1.45
Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. Am J Physiol Renal Physiol (2007) 1.45
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem (2008) 1.43
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol Gastrointest Liver Physiol (2003) 1.42
Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels. Am J Physiol Renal Physiol (2007) 1.37
Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension (2003) 1.36
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36
Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem (2005) 1.30
Pendrin modulates ENaC function by changing luminal HCO3-. J Am Soc Nephrol (2010) 1.29
Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J (2007) 1.29
NOX4 as an oxygen sensor to regulate TASK-1 activity. Cell Signal (2005) 1.28
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-). J Biol Chem (2004) 1.28
Dietary Cl(-) restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells. Am J Physiol Renal Physiol (2006) 1.27
Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. Cell Calcium (2007) 1.26
Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci (2008) 1.24
Calcium signaling complexes in microdomains of polarized secretory cells. Cell Calcium (2006) 1.24
Pancreatitis: the neglected duct. Gut (2008) 1.22
SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem (2004) 1.22
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol (2003) 1.20
Signalling specificity in GPCR-dependent Ca2+ signalling. Cell Signal (2003) 1.19
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. J Biol Chem (2011) 1.17
Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts. J Am Soc Nephrol (2009) 1.17
Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle (2005) 1.15
Desensitization of canonical transient receptor potential channel 5 by protein kinase C. Am J Physiol Cell Physiol (2005) 1.14
Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model. BMC Med (2006) 1.11
Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol (2009) 1.11
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10
AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol Cell Physiol (2002) 1.10
Activating of ATP-dependent K+ channels comprised of K(ir) 6.2 and SUR 2B by PGE2 through EP2 receptor in cultured interstitial cells of Cajal from murine small intestine. Cell Physiol Biochem (2006) 1.09
A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma. Curr Biol (2003) 1.08
The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function. J Cell Biol (2013) 1.07
The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem (2002) 1.06
Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters. J Gen Physiol (2011) 1.05
Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. Endocrinology (2007) 1.05
Regulatory interaction between CFTR and the SLC26 transporters. Novartis Found Symp (2006) 1.04
Angiotensin II activates H+-ATPase in type A intercalated cells. J Am Soc Nephrol (2008) 1.04
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. J Biol Chem (2012) 1.04
TRPpathies. J Physiol (2006) 1.04