Published in Development on December 15, 2008
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An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature (2016) 2.18
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81
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β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors. Cell Cycle (2010) 1.46
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PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation. J Biol Chem (2009) 1.20
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol (2012) 1.13
Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem (2010) 1.07
Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res (2013) 1.06
Functions of B56-containing PP2As in major developmental and cancer signaling pathways. Life Sci (2010) 0.99
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal (2011) 0.99
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development (2011) 0.98
The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation. J Biol Chem (2009) 0.90
Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner. Dev Biol (2012) 0.88
Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proc Natl Acad Sci U S A (2014) 0.88
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med (2015) 0.87
Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit. PLoS Biol (2013) 0.87
The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. J Biol Chem (2011) 0.87
Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation. Sci Signal (2014) 0.83
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. J Biol Chem (2013) 0.83
A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster. G3 (Bethesda) (2013) 0.82
Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling. PLoS One (2013) 0.80
A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics (2010) 0.80
Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development. Pharmaceuticals (Basel) (2016) 0.80
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Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol (2015) 0.79
Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS One (2012) 0.78
A rhamnose-binding lectin from sea bass (Dicentrarchus labrax) plasma agglutinates and opsonizes pathogenic bacteria. Dev Comp Immunol (2014) 0.77
Smoothened regulation in response to Hedgehog stimulation. Front Biol (Beijing) (2015) 0.76
The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One (2014) 0.76
SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling. Sci Rep (2017) 0.75
The emerging roles of phosphatases in Hedgehog pathway. Cell Commun Signal (2017) 0.75
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature (2007) 18.38
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
The Hedgehog and Wnt signalling pathways in cancer. Nature (2001) 9.19
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science (2006) 7.03
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The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer (2003) 4.86
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell (1997) 4.43
Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics (2006) 3.94
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell (2000) 3.10
Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol (2000) 2.80
Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell (1999) 2.70
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62
Novel protein serine/threonine phosphatases: variety is the spice of life. Trends Biochem Sci (1997) 2.54
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature (2004) 2.39
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell (1999) 2.34
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell (1993) 2.26
Hedgehog regulates smoothened activity by inducing a conformational switch. Nature (2007) 2.23
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Protein kinases and phosphatases in the Drosophila genome. J Cell Biol (2000) 1.81
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev (1999) 1.79
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development (2000) 1.75
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev (2000) 1.75
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol (2004) 1.69
Multiple protein phosphatases are required for mitosis in Drosophila. Curr Biol (2007) 1.68
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Regulation of Hh/Gli signaling by dual ubiquitin pathways. Cell Cycle (2006) 1.58
Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development (2002) 1.48
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev (2003) 1.44
Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr Biol (2005) 1.42
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development (2000) 1.41
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development (1998) 1.37
Decoding the Hedgehog signal in animal development. Cell Mol Life Sci (2006) 1.30
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci (1998) 1.28
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev (2007) 1.24
Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase. J Biol Chem (2001) 1.15
PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol (2006) 1.10
Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused. Curr Biol (2007) 1.08
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res (2008) 0.99
A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics (2008) 0.86
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem (2004) 5.80
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39
Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists. Arthritis Rheum (2013) 3.20
Tissue-dependent paired expression of miRNAs. Nucleic Acids Res (2007) 2.82
A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. J Physiol (2009) 2.59
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50
TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci (2005) 2.21
Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer. Liver Int (2012) 2.02
TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A (2006) 2.01
Cloning and expression profiling of testis-expressed microRNAs. Dev Biol (2007) 2.00
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (2011) 1.94
A PCR-based method for detection and quantification of small RNAs. Biochem Biophys Res Commun (2006) 1.91
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. J Biol Chem (2005) 1.90
Many X-linked microRNAs escape meiotic sex chromosome inactivation. Nat Genet (2009) 1.88
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
Serum response factor-dependent MicroRNAs regulate gastrointestinal smooth muscle cell phenotypes. Gastroenterology (2011) 1.79
PipeOnline 2.0: automated EST processing and functional data sorting. Nucleic Acids Res (2002) 1.65
Cloning and expression profiling of small RNAs expressed in the mouse ovary. RNA (2007) 1.65
Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol Aging (2010) 1.62
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG. J Biol Chem (2010) 1.60
Cloning and expression profiling of testis-expressed piRNA-like RNAs. RNA (2007) 1.52
Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem (2011) 1.50
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res (2011) 1.48
HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol (2013) 1.47
Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod (2007) 1.43
A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases. Gastroenterology (2009) 1.42
Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Biol Reprod (2005) 1.41
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Genomic structures of the human and murine corin genes and functional GATA elements in their promoters. J Biol Chem (2002) 1.37
Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. Eur Spine J (2006) 1.36
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology (2012) 1.36
The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis. J Biol Chem (2012) 1.34
A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther (2011) 1.34
Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer (2012) 1.33
Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol (2007) 1.31
MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway. J Biol Chem (2012) 1.31
Male germ cells express abundant endogenous siRNAs. Proc Natl Acad Sci U S A (2011) 1.29
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev (2007) 1.24
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res (2013) 1.24
Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet (2006) 1.23
Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm (2009) 1.22
Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. J Biol Chem (2002) 1.21
PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation. J Biol Chem (2009) 1.20
Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity. Biochem Biophys Res Commun (2002) 1.18
Obox, a family of homeobox genes preferentially expressed in germ cells. Genomics (2002) 1.18
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. J Biol Chem (2012) 1.16
Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci U S A (2007) 1.16
RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. Proc Natl Acad Sci U S A (2003) 1.14
miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. Eur J Cancer (2012) 1.14
The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins. J Gen Virol (2003) 1.14
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol (2012) 1.13
Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution. J Neurooncol (2013) 1.12
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol (2013) 1.11
Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B Biointerfaces (2011) 1.11
Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett (2011) 1.10
Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas. J Neurosci (2012) 1.10
Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro. Matrix Biol (2004) 1.10
Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity. J Biol Chem (2006) 1.10
MicroRNAs dynamically remodel gastrointestinal smooth muscle cells. PLoS One (2011) 1.09
Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. Eur J Cancer (2013) 1.09
Differential expression profiles of microRNAs in NIH3T3 cells in response to UVB irradiation. Photochem Photobiol (2008) 1.08
IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. Exp Mol Pathol (2009) 1.08
Production of Gene-Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation. Stem Cells (2015) 1.07
Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem (2010) 1.07
Transcriptional up-regulation of FoxM1 in response to hypoxia is mediated by HIF-1. J Cell Biochem (2009) 1.07
CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res (2014) 1.06
Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. Mol Reprod Dev (2004) 1.06
MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1. Oncol Rep (2012) 1.05
Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. Proc Natl Acad Sci U S A (2009) 1.05
Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol (2007) 1.05
Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol (2013) 1.05
Control of messenger RNA fate by RNA-binding proteins: an emphasis on mammalian spermatogenesis. J Androl (2011) 1.05
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem (2007) 1.05
Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome. Neuro Oncol (2012) 1.05
Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. Gene Expr Patterns (2003) 1.04
MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling. Cancer Lett (2012) 1.04
MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis. Int J Oncol (2011) 1.04
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
Effect of temperature on the population growth of Rhynchophorus ferrugineus (Coleoptera: Curculionidae) on sugarcane. Environ Entomol (2010) 1.04
Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma (2009) 1.04
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc Natl Acad Sci U S A (2012) 1.03
Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype. PLoS One (2012) 1.03
Prequips--an extensible software platform for integration, visualization and analysis of LC-MS/MS proteomics data. Bioinformatics (2009) 1.03
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol Neurodegener (2012) 1.02
Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways. Oncol Rep (2011) 1.02
Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol (2008) 1.02
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. Brain Res (2010) 1.02
Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma. Cancer Lett (2012) 1.01
Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Δ) mice. Genesis (2013) 1.01
The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice. Acta Pharmacol Sin (2010) 0.99